The physiology of the β-amyloid precursor protein intracellular domain AICD

Possible roles of amyloid intracellular domain of amyloid precursor protein

(2011) Keun-A Chang et al.   BMB Reports

Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling

(2011) Xuan Xu et al.   EMBO REPORTS

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome

(2011) Stefania Trazzi et al.   HUMAN MOLECULAR GENETICS

The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis

(2011) Donat Kögel et al.   NEUROBIOLOGY OF AGING

The type III TGF-β receptor betaglycan transmembrane–cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease γ-secretase

(2010) Cheyne R. Blair et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

β-Secretase-1 elevation in aged monkey and Alzheimer’s disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation

(2010) Yan Cai et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis

(2010) Takeshi Ohkawara et al.   GENE

Processing of the Synaptic Cell Adhesion Molecule Neurexin-3β by Alzheimer Disease α- and γ-Secretases

(2010) Nathalie Bot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secretion Stimulates Intramembrane Proteolysis of a Secretory Granule Membrane Enzyme

(2010) Chitra Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

(2010) Nikolai D. Belyaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential and  -secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth

(2010) A. Stoeck et al.   JOURNAL OF CELL SCIENCE

Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

(2010) Gen He et al.   NATURE

p53 Is Regulated by and Regulates Members of the γ-Secretase Complex

(2010) Frédéric Checler et al.   Neurodegenerative Diseases

S100a9 Knockdown Decreases the Memory Impairment and the Neuropathology in Tg2576 Mice, AD Animal Model

(2010) Tae-Young Ha et al.   PLoS One

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Epigenetic control of aquaporin 1 expression by the amyloid precursor protein

(2009) Sandra Huysseune et al.   FASEB JOURNAL

Klotho is a substrate for α-, β- and γ-secretase

(2009) Laura Bloch et al.   FEBS LETTERS

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation

(2009) Eiji Inoue et al.   JOURNAL OF CELL BIOLOGY

Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway

(2009) Z. V. Goodger et al.   JOURNAL OF CELL SCIENCE

p53-dependent control of transactivation of the Pen2 promoter by presenilins

(2009) J. Dunys et al.   JOURNAL OF CELL SCIENCE

c-Abl modulates AICD dependent cellular responses: Transcriptional induction and apoptosis

(2009) Mary C. Vázquez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway

(2009) Keita Takahashi et al.   JOURNAL OF NEUROCHEMISTRY

Pharmacological evidences for DFK167-sensitive presenilin-independent γ-secretase-like activity

(2009) Jean Sevalle et al.   JOURNAL OF NEUROCHEMISTRY

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

Down-Regulation of the Met Receptor Tyrosine Kinase by Presenilin-dependent Regulated Intramembrane Proteolysis

(2009) Bénédicte Foveau et al.   MOLECULAR BIOLOGY OF THE CELL

Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain

(2009) D.L. Vogt et al.   NEUROBIOLOGY OF AGING

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells

(2008) Yuanli Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

In vitro reconstitution of γ-secretase activity using yeast microsomes

(2008) Sosuke Yagishita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Substrate specificity of γ-secretase and other intramembrane proteases

(2008) A. J. Beel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ADAM10 Regulates Endothelial Permeability and T-Cell Transmigration by Proteolysis of Vascular Endothelial Cadherin

(2008) Beate Schulz et al.   CIRCULATION RESEARCH

Intracellular Amyloid β-Protein As a Therapeutic Target for Treating Alzheimers Disease

(2008) Y. Ohyagi   Current Alzheimer Research

Activity of γ -Secretase on Substrates Other than APP

(2008) Alberto D.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

(2008) Nikolai D Belyaev et al.   EMBO REPORTS

Interleukin-1 Receptor Type 1 Is a Substrate for γ-Secretase-dependent Regulated Intramembrane Proteolysis

(2008) Baukje M. Elzinga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Swedish amyloid precursor protein mutation increases cell cycle-related proteins in vitro and in vivo

(2008) Kwang-Woo Ahn et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories

(2008) Uwe Konietzko et al.   NEUROBIOLOGY OF AGING

The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis

(2008) Kohzo Nakayama et al.   NEUROSCIENCE LETTERS

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

(2008) Thorsten Müller et al.   PROGRESS IN NEUROBIOLOGY

Embryonic Stem Cell-Derived Neurons as a Cellular System to Study Gene Function: Lack of Amyloid Precursor Proteins APP and APLP2 Leads to Defective Synaptic Transmission

(2008) Katrin Schrenk-Siemens et al.   STEM CELLS

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

(2008) Matthew L Hemming et al.   PLOS BIOLOGY