Fatty Acids: An Insight into the Pathogenesis of Neurodegenerative Diseases and Therapeutic Potential

High-Fat Diet Impairs Mouse Median Eminence: A Study by Transmission and Scanning Electron Microscopy Coupled with Raman Spectroscopy

(2021) Ilenia Severi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prognostic biomarkers of Parkinson’s disease in the Spanish EPIC cohort: a multiplatform metabolomics approach

(2021) Carolina Gonzalez-Riano et al.   npj Parkinsons Disease

Lipids and Alzheimer’s Disease

(2020) Yu-Chia Kao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diagnosis and Treatment of Parkinson Disease

(2020) Melissa J. Armstrong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

n-3 Polyunsaturated Fatty Acids and Their Derivates Reduce Neuroinflammation during Aging

(2020) Corinne Joffre et al.   Nutrients

Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

(2020) Helen M. Melo et al.   Cell Reports

The Contribution of Astrocyte Autophagy to Systemic Metabolism

(2020) Ana Ortiz-Rodriguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases

(2020) Wioletta Rozpędek-Kamińska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Docosahexaenoic acid protection against palmitic acid‐induced lipotoxicity in NGF differentiated PC12 cells involves enhancement of autophagy and inhibition of apoptosis and necroptosis

(2020) Manuel L. Montero et al.   JOURNAL OF NEUROCHEMISTRY

Role of dietary fatty acids in microglial polarization in Alzheimer’s disease

(2020) Smita Eknath Desale et al.   Journal of Neuroinflammation

Oral Administration of Alpha Linoleic Acid Rescues Aβ-Induced Glia-Mediated Neuroinflammation and Cognitive Dysfunction in C57BL/6N Mice

(2020) Waqar Ali et al.   Cells

Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

(2020) Plamena R. Angelova et al.   MEDICINAL RESEARCH REVIEWS

Tibolone Ameliorates the Lipotoxic Effect of Palmitic Acid in Normal Human Astrocytes

(2020) Cynthia Martin-Jiménez et al.   NEUROTOXICITY RESEARCH

Lipid Droplets in Neurodegenerative Disorders

(2020) Brandon C. Farmer et al.   Frontiers in Neuroscience

The Biochemical Profile of Post-Mortem Brain from People Who Suffered from Epilepsy Reveals Novel Insights into the Etiopathogenesis of the Disease

(2020) Ashna M. Lalwani et al.   Metabolites

Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane

(2020) Matilda Katan et al.   Essays in Biochemistry

The Role of Lipids in Parkinson’s Disease

(2019) Helena Xicoy et al.   Cells

Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5

(2019) María Paz Hernández-Cáceres et al.   Frontiers in Endocrinology

New Insights on the Nutrition Status and Antioxidant Capacity in Multiple Sclerosis Patients

(2019) Ayelet Armon-Omer et al.   Nutrients

Endoplasmic Reticulum Stress, the Hypothalamus, and Energy Balance

(2019) Isin Cakir et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

NDP-MSH reduces oxidative damage induced by palmitic acid in primary astrocytes

(2019) Delia Ramírez et al.   JOURNAL OF NEUROENDOCRINOLOGY

A Diet Enriched in Palmitate and Deficient in Linoleate Exacerbates Oxidative Stress and Amyloid-β Burden in the Hippocampus of 3xTg-AD Mouse Model of Alzheimer’s Disease

(2019) Gurdeep Marwarha et al.   JOURNAL OF ALZHEIMERS DISEASE

Palmitoylation-mediated synaptic regulation of AMPA receptor trafficking and function

(2019) Heesung Sohn et al.   ARCHIVES OF PHARMACAL RESEARCH

Linoleic acid rescues microglia inflammation triggered by saturated fatty acid

(2019) Thai Hien Tu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tibolone attenuates inflammatory response by palmitic acid and preserves mitochondrial membrane potential in astrocytic cells through estrogen receptor beta

(2019) Yeimy González-Giraldo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dysregulated Lipid Metabolism and Its Role in α-Synucleinopathy in Parkinson’s Disease

(2019) Irina Alecu et al.   Frontiers in Neuroscience

Palmitic acid is an intracellular signaling molecule involved in disease development

(2019) Sarwat Fatima et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

(2019) Jan Korbecki et al.   INFLAMMATION RESEARCH

Modifiable Risk Factors for Alzheimer’s Disease

(2019) George A. Edwards III et al.   Frontiers in Aging Neuroscience

Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica

(2019) Kumiko Nakada-Tsukui et al.   Frontiers in Cellular and Infection Microbiology

Lipid and Lipid Raft Alteration in Aging and Neurodegenerative Diseases: A Window for the Development of New Biomarkers

(2019) Mesa-Herrera et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypothalamic Fatty Acids and Ketone Bodies Sensing and Role of FAT/CD36 in the Regulation of Food Intake

(2019) Christelle Le Foll   Frontiers in Physiology

Mechanisms of secretion and spreading of pathological tau protein

(2019) Cecilia A. Brunello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells

(2019) George Anderson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function

(2019) Bee Ling Tan et al.   Nutrients

Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis

(2019) L. Nogueras et al.   Scientific Reports

Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases

(2019) Alain Couvineau et al.   Frontiers in Endocrinology

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease

(2019) Carroll Rutherford Fields et al.   Frontiers in Molecular Neuroscience

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

(2018) Plamena R. Angelova et al.   FEBS LETTERS

Palmitate induces neuroinflammation, ER stress, and Pomc mRNA expression in hypothalamic mHypoA-POMC/GFP neurons through novel mechanisms that are prevented by oleate

(2018) Erika K. Tse et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Lipotoxic Effects of Palmitic Acid on Astrocytes Are Associated with Autophagy Impairment

(2018) Ana Ortiz-Rodriguez et al.   MOLECULAR NEUROBIOLOGY

Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid β-peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse model of Alzheimer's disease

(2018) Sophia M. Raefsky et al.   NEUROBIOLOGY OF AGING

Crosstalk between endoplasmic reticulum stress and brain inflammation in Alzheimer's disease

(2018) Luis E. Santos et al.   NEUROPHARMACOLOGY

Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4

(2018) Domenico Sergi et al.   NUTRITIONAL NEUROSCIENCE

Mechanisms of Endogenous Neuroprotective Effects of Astrocytes in Brain Injury

(2018) Michelle A. Bylicky et al.   Oxidative Medicine and Cellular Longevity

The autophagic degradation of Cav-1 contributes to PA-induced apoptosis and inflammation of astrocytes

(2018) Zi Chen et al.   Cell Death & Disease

Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease

(2018) Shoko Hashimoto et al.   Open Biology

Palmitoylation as a Functional Regulator of Neurotransmitter Receptors

(2018) Vladimir S. Naumenko et al.   NEURAL PLASTICITY

Insights Into Protein S-Palmitoylation in Synaptic Plasticity and Neurological Disorders: Potential and Limitations of Methods for Detection and Analysis

(2018) Monika Zaręba-Kozioł et al.   Frontiers in Molecular Neuroscience

Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease

(2018) Timothy J. Tracey et al.   Frontiers in Molecular Neuroscience

Palmitic acid induces neurotoxicity and gliatoxicity in SH-SY5Y human neuroblastoma and T98G human glioblastoma cells

(2018) Yee-Wen Ng et al.   PeerJ

Sodium Butyrate Improves Memory Function in an Alzheimer's Disease Mouse Model When Administered at an Advanced Stage of Disease Progression

(2018) Nambirajan Govindarajan et al.   JOURNAL OF ALZHEIMERS DISEASE

Dysregulation of PI3K-Akt-mTOR pathway in brain of streptozotocin-induced type 2 diabetes mellitus in Wistar rats

(2018) Siresha Bathina et al.   Lipids in Health and Disease

Treatment of neurodegenerative disorders through the blood–brain barrier using nanocarriers

(2018) N. Poovaiah et al.   Nanoscale

Redox Balance, Antioxidant Defense, and Oxidative Damage in the Hypothalamus and Cerebral Cortex of Rats with High Fat Diet-Induced Insulin Resistance

(2018) Mateusz Maciejczyk et al.   Oxidative Medicine and Cellular Longevity

Protective effect of docosahexaenoic acid on lipotoxicity-mediated cell death in Schwann cells: Implication of PI3K/AKT and mTORC2 pathways

(2018) Magda Descorbeth et al.   Brain and Behavior

Palmitic Acid-Enriched Diet Increases α-Synuclein and Tyrosine Hydroxylase Expression Levels in the Mouse Brain

(2018) Jared Schommer et al.   Frontiers in Neuroscience

Triglyceride Form of Docosahexaenoic Acid Mediates Neuroprotection in Experimental Parkinsonism

(2018) Maricel Gómez-Soler et al.   Frontiers in Neuroscience

PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

(2018) Karina Sánchez-Alegría et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss

(2018) C.M. Duffy et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability

(2018) Alejandra D. Alonso et al.   Frontiers in Cellular Neuroscience

Deuterium-reinforced polyunsaturated fatty acids improve cognition in a mouse model of sporadic Alzheimer's disease

(2017) Ahmed Elharram et al.   FEBS Journal

Hypothalamic lipid-laden astrocytes induce microglia migration and activation

(2017) Yoon-Hee Kwon et al.   FEBS LETTERS

Fats for thoughts: An update on brain fatty acid metabolism

(2017) Adele Romano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Activation of the NLRP3 inflammasome in microglia: the role of ceramide

(2017) Hannah Scheiblich et al.   JOURNAL OF NEUROCHEMISTRY

Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid

(2017) Yeimy González-Giraldo et al.   MOLECULAR NEUROBIOLOGY

Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta

(2017) Oscar Hidalgo-Lanussa et al.   MOLECULAR NEUROBIOLOGY

NADPH oxidases in Parkinson’s disease: a systematic review

(2017) Karim Belarbi et al.   Molecular Neurodegeneration

Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease

(2017) Jennifer M. Walker et al.   NEUROBIOLOGY OF DISEASE

Palmitic acid stimulates energy metabolism and inhibits insulin/PI3K/AKT signaling in differentiated human neuroblastoma cells: The role of mTOR activation and mitochondrial ROS production

(2017) Erika Calvo-Ochoa et al.   NEUROCHEMISTRY INTERNATIONAL

Ceramide and Its Related Neurochemical Networks as Targets for Some Brain Disorder Therapies

(2017) Justyna Brodowicz et al.   NEUROTOXICITY RESEARCH

Fatty Acids, Antioxidants and Physical Activity in Brain Aging

(2017) Hércules Freitas et al.   Nutrients

Estradiol Uses Different Mechanisms in Astrocytes from the Hippocampus of Male and Female Rats to Protect against Damage Induced by Palmitic Acid

(2017) Laura M. Frago et al.   Frontiers in Molecular Neuroscience

Brain Ceramide Metabolism in the Control of Energy Balance

(2017) Céline Cruciani-Guglielmacci et al.   Frontiers in Physiology

Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications

(2017) Gianfranca Carta et al.   Frontiers in Physiology

Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation

(2017) J.D. Douglass et al.   Molecular Metabolism

Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat

(2017) Ann-Charlotte Granholm et al.   JOURNAL OF ALZHEIMERS DISEASE

Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways

(2017) Jeong Yeon Kim et al.   Scientific Reports

Fatty acid-induced astrocyte ketone production and the control of food intake

(2016) Christelle Le Foll et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain

(2016) Gurdeep Marwarha et al.   CELLULAR SIGNALLING

Maternal Obesity in the Mouse Compromises the Blood-Brain Barrier in the Arcuate Nucleus of Offspring

(2016) Dong Won Kim et al.   ENDOCRINOLOGY

Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte–neuron lactate and ketone body shuttle systems

(2016) Jonathan Thevenet et al.   FASEB JOURNAL

ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation

(2016) Patricia Marie-Jeanne Lievens et al.   MOLECULAR AND CELLULAR BIOLOGY

Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP

(2016) Dean Q. Tran et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Relationship Between Obesity, Alzheimer’s Disease, and Parkinson’s Disease: an Astrocentric View

(2016) Cynthia Alexandra Martin-Jiménez et al.   MOLECULAR NEUROBIOLOGY

Inflammatory Response in the CNS: Friend or Foe?

(2016) Marta Sochocka et al.   MOLECULAR NEUROBIOLOGY

Nerve growth factor protects against palmitic acid-induced injury in retinal ganglion cells

(2016) Zhi-wen Zeng et al.   Neural Regeneration Research

Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders

(2016) Fabio Arturo Iannotti et al.   PROGRESS IN LIPID RESEARCH

25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

(2016) Jiho Jang et al.   Nature Communications

The Effects of Long-Term Saturated Fat Enriched Diets on the Brain Lipidome

(2016) Corey Giles et al.   PLoS One

Comparative Proteomic Study of Fatty Acid-treated Myoblasts Reveals Role of Cox-2 in Palmitate-induced Insulin Resistance

(2016) Xiulan Chen et al.   Scientific Reports

Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation

(2015) Michael X. Henderson et al.   ACTA NEUROPATHOLOGICA

Lipids in the nervous system: From biochemistry and molecular biology to patho-physiology

(2015) Gaia Cermenati et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Programmed Cell Death in Neurodevelopment

(2015) Yoshifumi Yamaguchi et al.   DEVELOPMENTAL CELL

Regulation of neuronal communication by G protein-coupled receptors

(2015) Yunhong Huang et al.   FEBS LETTERS

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

A sexually dimorphic hypothalamic response to chronic high-fat diet consumption

(2015) E Morselli et al.   INTERNATIONAL JOURNAL OF OBESITY

Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner

(2015) Eiji Kakazu et al.   JOURNAL OF LIPID RESEARCH

Omega-3 polyunsaturated fatty acid supplementation and cognition: A systematic review and meta-analysis

(2015) Ruth E Cooper et al.   JOURNAL OF PSYCHOPHARMACOLOGY

N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution

(2015) Stephen D. Skaper et al.   MOLECULAR NEUROBIOLOGY

Examining the relationship between obesity and cognitive function: A systematic literature review

(2015) Christina Prickett et al.   Obesity Research & Clinical Practice

Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers

(2015) Shaun S. Sanders et al.   PLoS Computational Biology

NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain

(2015) Barbara Kaltschmidt et al.   Frontiers in Molecular Neuroscience

Hypothalamic tanycytes—masters and servants of metabolic, neuroendocrine, and neurogenic functions

(2015) Timothy Goodman et al.   Frontiers in Neuroscience

Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice

(2015) Laura B. Buckman et al.   Molecular Metabolism

Protective effect of arachidonic acid and linoleic acid on 1-methyl-4-phenylpyridinium-induced toxicity in PC12 cells

(2015) Kim Tang   Lipids in Health and Disease

Saturated Fatty Acids Modulate Autophagy’s Proteins in the Hypothalamus

(2015) Mariana Portovedo et al.   PLoS One

PGC−1α Promoter Methylation in Parkinson’s Disease

(2015) Xiaomin Su et al.   PLoS One

2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease

(2014) Keith N. Fargo et al.   Alzheimers & Dementia

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells

(2014) Bumsup Kwon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy in the physiology and pathology of the central nervous system

(2014) V Nikoletopoulou et al.   CELL DEATH AND DIFFERENTIATION

In vitrotreatment of HepG2 cells with saturated fatty acids reproduces mitochondrial dysfunction found in nonalcoholic steatohepatitis

(2014) Inmaculada García-Ruiz et al.   Disease Models & Mechanisms

Lipids IN the brain: Crossing the “insurmountable” barrier for a fatty, happy life

(2014) Emma De Fabiani   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

(2014) Stefanie L. Butland et al.   HUMAN MOLECULAR GENETICS

Palmitic Acid-Induced Neuron Cell Cycle G2/M Arrest and Endoplasmic Reticular Stress through Protein Palmitoylation in SH-SY5Y Human Neuroblastoma Cells

(2014) Yung-Hsuan Hsiao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological Treatment of Parkinson Disease

(2014) Barbara S. Connolly et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

Palmitic acid-induced lipotoxicity and protection by (+)-catechin in rat cortical astrocytes

(2014) Kar-Lok Wong et al.   Pharmacological Reports

Increasing Fatty Acid Oxidation Remodels the Hypothalamic Neurometabolome to Mitigate Stress and Inflammation

(2014) Joseph W. McFadden et al.   PLoS One

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

Fatty Acids in Energy Metabolism of the Central Nervous System

(2014) Alexander Panov et al.   Biomed Research International

Dietary ω-3 Polyunsaturated Fatty Acid Intake and Risk for Amyotrophic Lateral Sclerosis

(2014) Kathryn C. Fitzgerald et al.   JAMA Neurology

Long-Chain Omega-3 Fatty Acids Improve Brain Function and Structure in Older Adults

(2013) A. Veronica Witte et al.   CEREBRAL CORTEX

Effect of Diet on Tissue Levels of Palmitoylethanolamide

(2013) Harald S. Hansen   CNS & Neurological Disorders-Drug Targets

Biosynthetic Pathways of Bioactive N-Acylethanolamines in Brain

(2013) Kazuhito Tsuboi et al.   CNS & Neurological Disorders-Drug Targets

Mechanisms of Palmitate-Induced Lipotoxicity in Human Osteoblasts

(2013) Krishanthi Gunaratnam et al.   ENDOCRINOLOGY

Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes

(2013) Li Liu et al.   EXPERIMENTAL NEUROLOGY

What does S-palmitoylation do to membrane proteins?

(2013) Sanja Blaskovic et al.   FEBS Journal

Palmitoylation of Superoxide Dismutase 1 (SOD1) Is Increased for Familial Amyotrophic Lateral Sclerosis-linked SOD1 Mutants

(2013) Sarah E. Antinone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain

(2013) Peter Schönfeld et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exposure to the Saturated Free Fatty Acid Palmitate Alters BV-2 Microglia Inflammatory Response

(2013) Linda M. Tracy et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts

(2013) R. Bhattacharyya et al.   JOURNAL OF NEUROSCIENCE

Obesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Disease

(2013) Z. Tucsek et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

IPAF inflammasome is involved in interleukin-1β production from astrocytes, induced by palmitate; implications for Alzheimer's Disease

(2013) Li Liu et al.   NEUROBIOLOGY OF AGING

Cholesterol as a co-solvent and a ligand for membrane proteins

(2013) Yuanli Song et al.   PROTEIN SCIENCE

A fatty gut feeling

(2013) Daniele Piomelli   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death

(2012) Aaron C. Baldwin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling

(2012) Hui Zheng et al.   BMC CELL BIOLOGY

Ceramide function in the brain: when a slight tilt is enough

(2012) Chiara Mencarelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Palmitoylated calnexin is a key component of the ribosome-translocon complex

(2012) Asvin KK Lakkaraju et al.   EMBO JOURNAL

Saturated long-chain fatty acids activate inflammatory signaling in astrocytes

(2012) Sunita Gupta et al.   JOURNAL OF NEUROCHEMISTRY

Omega-3 fatty acid eicospentaenoic acid attenuates MPP+-induced neurodegeneration in fully differentiated human SH-SY5Y and primary mesencephalic cells

(2012) Dirk W. Luchtman et al.   JOURNAL OF NEUROCHEMISTRY

Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxiety-like behavior in mice

(2012) Thomas Larrieu et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Palmitoylation Regulates Intracellular Trafficking of β2 Adrenergic Receptor/Arrestin/Phosphodiesterase 4D Complexes in Cardiomyocytes

(2012) Ruijie Liu et al.   PLoS One

Caprylic Triglyceride as a Novel Therapeutic Approach to Effectively Improve the Performance and Attenuate the Symptoms Due to the Motor Neuron Loss in ALS Disease

(2012) Wei Zhao et al.   PLoS One

Palmitic acid increases apoptosis of neural stem cells via activating c-Jun N-terminal kinase

(2012) Qiuhuan Yuan et al.   Stem Cell Research

Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease

(2011) D.W. Luchtman et al.   BEHAVIOURAL BRAIN RESEARCH

AMPK activation inhibits apoptosis and tau hyperphosphorylation mediated by palmitate in SH-SY5Y cells

(2011) Juhae Kim et al.   BRAIN RESEARCH

Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling

(2011) Zhen Wang et al.   BRITISH JOURNAL OF NUTRITION

Effects of palmitoylation of Cys415 in helix 8 of the CB1 cannabinoid receptor on membrane localization and signalling

(2011) Sergio Oddi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Origins of metabolic complications in obesity

(2011) Stefania Carobbio et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Posttranslational regulation of AMPA receptor trafficking and function

(2011) Wei Lu et al.   CURRENT OPINION IN NEUROBIOLOGY

Novel Membrane-associated Androgen Receptor Splice Variant Potentiates Proliferative and Survival Responses in Prostate Cancer Cells

(2011) Xi Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation

(2011) Pratibha V Nerurkar et al.   Journal of Neuroinflammation

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(2011) Noemi Fabelo et al.   MOLECULAR MEDICINE

Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions

(2011) Mathieu Lafourcade et al.   NATURE NEUROSCIENCE

NADPH oxidase is involved in post-ischemic brain inflammation

(2011) Hai Chen et al.   NEUROBIOLOGY OF DISEASE

DHA Supplemented in Peptamen Diet Offers No Advantage in Pathways to Amyloidosis: Is It Time to Evaluate Composite Lipid Diet?

(2011) Zareen Amtul et al.   PLoS One

Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases

(2011) Fiona B. Young et al.   PROGRESS IN NEUROBIOLOGY

Glycosphingolipid Functions

(2011) C. A. Lingwood   Cold Spring Harbor Perspectives in Biology

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

(2010) Jeffrey D. Rothstein   ANNALS OF NEUROLOGY

Greasing Their Way: Lipid Modifications Determine Protein Association with Membrane Rafts

(2010) Ilya Levental et al.   BIOCHEMISTRY

Obesity as a clinical and public health problem: Is there a need for a new definition based on lipotoxicity effects?

(2010) Thorkild I.A. Sørensen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective

(2010) Sam Virtue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum

(2010) Rick F. Thorne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Increased Brain Fatty Acid Uptake in Metabolic Syndrome

(2010) A. Karmi et al.   DIABETES

Ethyl-eicosapentaenoate modulates changes in neurochemistry and brain lipids induced by parkinsonian neurotoxin 1-methyl-4-phenylpyridinium in mouse brain slices

(2010) QingJia Meng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sequential and  -secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth

(2010) A. Stoeck et al.   JOURNAL OF CELL SCIENCE

The Clinical and Genetic Features of Huntington Disease

(2010) Aaron Sturrock et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Palmitate induces apoptosis in Schwann cells via both ceramide-dependent and independent pathways

(2010) J. Suzuki et al.   NEUROSCIENCE

Activation of NF-κB by Palmitate in Endothelial Cells

(2009) Ezekiel Maloney et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lipid homeostasis, lipotoxicity and the metabolic syndrome

(2009) Roger H. Unger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia

(2009) K. A. Page et al.   DIABETES

Medium-chain fatty acids ameliorate insulin resistance caused by high-fat diets in rats

(2009) Silvia Wein et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

(2009) Claudio Hetz et al.   MOLECULAR CELL

Ras acylation, compartmentalization and signaling nanoclusters (Review)

(2009) Yoav I. Henis et al.   MOLECULAR MEMBRANE BIOLOGY

Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond

(2009) A. Christine Könner et al.   PHYSIOLOGY & BEHAVIOR

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

(2009) Juliana C. Moraes et al.   PLoS One

Breastfeeding and Child Cognitive Development

(2008) Michael S. Kramer   ARCHIVES OF GENERAL PSYCHIATRY

Obesity and Hypertriglyceridemia Produce Cognitive Impairment

(2008) Susan A. Farr et al.   ENDOCRINOLOGY

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

(2008) Alexis M. Stranahan et al.   HIPPOCAMPUS

Loss of cardiolipin in palmitate-treated GL15 glioblastoma cells favors cytochrome c release from mitochondria leading to apoptosis

(2008) Morena Buratta et al.   JOURNAL OF NEUROCHEMISTRY

Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes

(2008) Vidudala V.T.S. Prasad et al.   NEUROCHEMISTRY INTERNATIONAL

Peroxisome Proliferator-Activated Receptorβ/δin the Brain: Facts and Hypothesis

(2008) M. G. Hall et al.   PPAR Research