Activation of the NLRP3 inflammasome in microglia: the role of ceramide

Effect of FTY720-phosphate on the expression of inflammation-associated molecules in astrocytes in vitro

(2015) STEFANIE JANSSEN et al.   Molecular Medicine Reports

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

The role of inflammasome in Alzheimer's disease

(2014) Li Liu et al.   AGEING RESEARCH REVIEWS

Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling

(2014) Agnieszka Płóciennikowska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

Inflammasome-Mediated Secretion of IL-1  in Human Monocytes through TLR2 Activation; Modulation by Dietary Fatty Acids

(2013) R. G. Snodgrass et al.   JOURNAL OF IMMUNOLOGY

Exposure to the Saturated Free Fatty Acid Palmitate Alters BV-2 Microglia Inflammatory Response

(2013) Linda M. Tracy et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Ceramide function in the brain: when a slight tilt is enough

(2012) Chiara Mencarelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Goodpasture Antigen-binding Protein/Ceramide Transporter Binds to Human Serum Amyloid P-Component and Is Present in Brain Amyloid Plaques

(2012) Chiara Mencarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases

(2012) Li Liu et al.   NEUROBIOLOGY OF AGING

It’s a Lipid’s World: Bioactive Lipid Metabolism and Signaling in Neural Stem Cell Differentiation

(2012) Erhard Bieberich   NEUROCHEMICAL RESEARCH

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

(2011) Nadia M. Luheshi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MicroRNA-137/181c Regulates Serine Palmitoyltransferase and In Turn Amyloid  , Novel Targets in Sporadic Alzheimer's Disease

(2011) H. Geekiyanage et al.   JOURNAL OF NEUROSCIENCE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

(2010) Suriyan Ponnusamy et al.   Future Oncology

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

CERT-mediated trafficking of ceramide

(2009) Kentaro Hanada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Albumin activates astrocytes and microglia through mitogen-activated protein kinase pathways

(2009) Hantamalala Ralay Ranaivo et al.   BRAIN RESEARCH

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

The role of inflammation in CNS injury and disease

(2006) Sian-Marie Lucas et al.   BRITISH JOURNAL OF PHARMACOLOGY