N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution

Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis

(2015) Laura A.N. Peferoen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Synthesis, Structure-Activity, and Structure-Stability Relationships of 2-Substituted-N-(4-oxo-3-oxetanyl)N-Acylethanolamine Acid Amidase (NAAA) Inhibitors

(2014) Romina Vitale et al.   ChemMedChem

Oxidative Stress and Psychological Disorders

(2014) Samina Salim   Current Neuropharmacology

Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain

(2014) Daniela Impellizzeri et al.   Journal of Neuroinflammation

Crtc1 Activates a Transcriptional Program Deregulated at Early Alzheimer's Disease-Related Stages

(2014) A. Parra-Damas et al.   JOURNAL OF NEUROSCIENCE

Macroglia-Microglia Interactions via TSPO Signaling Regulates Microglial Activation in the Mouse Retina

(2014) M. Wang et al.   JOURNAL OF NEUROSCIENCE

Peripheral gating of pain signals by endogenous lipid mediators

(2014) Daniele Piomelli et al.   NATURE NEUROSCIENCE

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations

(2013) Sören V. Siegmund et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Palmitoylethanolamide and Luteolin in an Animal Model of Anxiety/Depression

(2013) Rosalia Crupi et al.   CNS & Neurological Disorders-Drug Targets

Systemic Oxidative Stress in Older Patients with Mild Cognitive Impairment or Late Onset Alzheimer's Disease

(2013) Carlo Cervellati et al.   Current Alzheimer Research

The Use of Flavonoids in Central Nervous System Disorders

(2013) C. Grosso et al.   CURRENT MEDICINAL CHEMISTRY

Immune dysregulation in autism spectrum disorder

(2013) Daniela Briceno Noriega et al.   EUROPEAN JOURNAL OF PEDIATRICS

Metabolism of endocannabinoids and relatedN-acylethanolamines: Canonical and alternative pathways

(2013) Natsuo Ueda et al.   FEBS Journal

Mast cells, glia and neuroinflammation: partners in crime?

(2013) Stephen D. Skaper et al.   IMMUNOLOGY

Innate and adaptive immune responses in neurodegeneration and repair

(2013) Sandra Amor et al.   IMMUNOLOGY

Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice

(2013) Friedrich Felix Hoyer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Neuroinflammation and psychiatric illness

(2013) Souhel Najjar et al.   Journal of Neuroinflammation

A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury

(2013) Irene Paterniti et al.   Journal of Neuroinflammation

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Mast cells on the mind: new insights and opportunities

(2013) Rae Silver et al.   TRENDS IN NEUROSCIENCES

Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase

(2012) Yumiko Yamano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Microglia and mast cells: two tracks on the road to neuroinflammation

(2012) Stephen D. Skaper et al.   FASEB JOURNAL

Mast Cells in the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

(2012) Massimo Costanza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis and Structure–Activity and Structure–Property Relationships

(2012) Andrea Duranti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models

(2012) Oscar Sasso et al.   PAIN

Mast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide

(2012) S. D. Skaper et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury

(2011) Emanuela Esposito et al.   BRAIN BEHAVIOR AND IMMUNITY

Acute amygdaloid response to systemic inflammation

(2011) Harald Engler et al.   BRAIN BEHAVIOR AND IMMUNITY

Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

(2011) Dae Kim et al.   Journal of Neuroinflammation

Surface TLR2 and TLR4 Expression on Mature Rat Mast Cells Can Be Affected by Some Bacterial Components and Proinflammatory Cytokines

(2011) Anna Pietrzak et al.   MEDIATORS OF INFLAMMATION

Central Nervous System Mast Cells in Peripheral Inflammatory Nociception

(2011) Dimitris N Xanthos et al.   Molecular Pain

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

A granular variant of CD63 is a regulator of repeated human mast cell degranulation

(2010) T. Schäfer et al.   ALLERGY

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

(2010) Koen Bossers et al.   BRAIN

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Mast Cells as Early Responders in the Regulation of Acute Blood–Brain Barrier Changes after Cerebral Ischemia and Hemorrhage

(2010) Perttu Johannes Lindsberg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients

(2010) Milan Fiala et al.   Journal of Neuroinflammation

Chronic stress induces transient spinal neuroinflammation, triggering sensory hypersensitivity and long-lasting anxiety-induced hyperalgesia

(2010) Cyril Rivat et al.   PAIN

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase

(2009) Carmela Saturnino et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats

(2009) Bei Xu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation

(2009) C. Solorzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Responses to Danger Signals in Systemic Inflammatory Response Syndrome and Sepsis

(2009) A. Castellheim et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Assessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activity

(2007) Miguel Coleta et al.   BEHAVIOURAL BRAIN RESEARCH