Lipid Droplets in Neurodegenerative Disorders

The fat brain

(2020) Jorge Montesinos et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

Spastin mutations impair coordination between lipid droplet dispersion and reticulum

(2020) Yoan Arribat et al.   PLoS Genetics

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

(2019) Brandon Farmer et al.   Cells

Neutral Lipid Storage Diseases as Cellular Model to Study Lipid Droplet Function

(2019) Sara Missaglia et al.   Cells

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

(2019) Changjun Yin et al.   NATURE MEDICINE

FABP7 Protects Astrocytes Against ROS Toxicity via Lipid Droplet Formation

(2019) Ariful Islam et al.   MOLECULAR NEUROBIOLOGY

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

(2019) Rik van der Kant et al.   Cell Stem Cell

The Parkinson-associated human P5B-ATPase ATP13A2 modifies lipid homeostasis

(2019) Alejandra Lucía Marcos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance

(2019) Seolsong Kim et al.   Autophagy

Oleic acid is a potent inducer for lipid droplet accumulation through its esterification to glycerol by diacylglycerol acyltransferase in primary cortical astrocytes

(2019) Shingo Nakajima et al.   BRAIN RESEARCH

Telmisartan prevents development of obesity and normalizes hypothalamic lipid droplets

(2019) Elias Rawish et al.   JOURNAL OF ENDOCRINOLOGY

Energy metabolism in ALS: an underappreciated opportunity?

(2018) Tijs Vandoorne et al.   ACTA NEUROPATHOLOGICA

Quantitative analysis of lipid debris accumulation caused by cuprizone induced myelin degradation in different CNS areas

(2018) Attila Ozsvár et al.   BRAIN RESEARCH BULLETIN

Emerging Links between Lipid Droplets and Motor Neuron Diseases

(2018) Giuseppa Pennetta et al.   DEVELOPMENTAL CELL

Diaphanous 1 (DIAPH1) is Highly Expressed in the Aged Human Medial Temporal Cortex and Upregulated in Myeloid Cells During Alzheimer’s Disease

(2018) Julia Derk et al.   JOURNAL OF ALZHEIMERS DISEASE

In vitro exploration of ACAT contributions to lipid droplet formation during adipogenesis

(2018) Yuyan Zhu et al.   JOURNAL OF LIPID RESEARCH

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Plin4-Dependent Lipid Droplets Hamper Neuronal Mitophagy in the MPTP/p-Induced Mouse Model of Parkinson’s Disease

(2018) Xiaojuan Han et al.   Frontiers in Neuroscience

A role for autophagy in Huntington's disease

(2018) Katherine R. Croce et al.   NEUROBIOLOGY OF DISEASE

A C9orf72–CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress

(2018) Yang Liu et al.   GENES & DEVELOPMENT

Reactive Oxygen Species Induces Lipid Droplet Accumulation in HepG2 Cells by Increasing Perilipin 2 Expression

(2018) Yi Jin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier

(2018) Laura Cristina Ceafalan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

(2018) Saranna Fanning et al.   MOLECULAR CELL

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Huntington's disease: a clinical review

(2017) P. McColgan et al.   EUROPEAN JOURNAL OF NEUROLOGY

Hypothalamic lipid-laden astrocytes induce microglia migration and activation

(2017) Yoon-Hee Kwon et al.   FEBS LETTERS

Glial lipid droplets and neurodegeneration in a Drosophila model of complex I deficiency

(2017) Marie-Jeanne Cabirol-Pol et al.   GLIA

The protein and neutral lipid composition of lipid droplets isolated from the fission yeast, Schizosaccharomyces pombe

(2017) Alex Meyers et al.   JOURNAL OF MICROBIOLOGY

Loss of spatacsin function alters lysosomal lipid clearance leading to upper and lower motor neuron degeneration

(2017) Julien Branchu et al.   NEUROBIOLOGY OF DISEASE

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism

(2017) Kimberley D. Bruce et al.   Frontiers in Endocrinology

Hereditary Spastic Paraplegia: Clinical and Genetic Hallmarks

(2016) Paulo Victor Sgobbi de Souza et al.   CEREBELLUM

Lipid droplets in activated mast cells – a significant source of triglyceride-derived arachidonic acid for eicosanoid production

(2016) Andrea Dichlberger et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation and Functions of Autophagic Lipolysis

(2016) Francesca Cingolani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Altered lipid metabolism in Drosophila model of Huntington’s disease

(2016) Kumari Aditi et al.   Scientific Reports

Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes

(2016) Marilia Kimie Shimabukuro et al.   Scientific Reports

Use of a Lipid-Coated Mesoporous Silica Nanoparticle Platform for Synergistic Gemcitabine and Paclitaxel Delivery to Human Pancreatic Cancer in Mice

(2015) Huan Meng et al.   ACS Nano

Lipoprotein lipase is an important modulator of lipid uptake and storage in hypothalamic neurons

(2015) Andrew E. Libby et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis

(2015) Jaeyong Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila

(2015) Andrew P. Bailey et al.   CELL

Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease

(2015) Laura K. Hamilton et al.   Cell Stem Cell

Expanding Roles for Lipid Droplets

(2015) Michael A. Welte   CURRENT BIOLOGY

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

ApoE4 upregulates the activity of mitochondria-associated ER membranes

(2015) M. D. Tambini et al.   EMBO REPORTS

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Specialized Cortex Glial Cells Accumulate Lipid Droplets in Drosophila melanogaster

(2015) Viktor Kis et al.   PLoS One

Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity

(2015) Elizabeth A. Stoll et al.   STEM CELLS

Spastin Binds to Lipid Droplets and Affects Lipid Metabolism

(2015) Chrisovalantis Papadopoulos et al.   PLoS Genetics

Network Analyses Reveal Novel Aspects of ALS Pathogenesis

(2015) Mario Sanhueza et al.   PLoS Genetics

Cholesterol metabolism and homeostasis in the brain

(2015) Juan Zhang et al.   Protein & Cell

Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

(2014) Dun-Sheng Yang et al.   BRAIN

Hereditary spastic paraplegia: Clinical-genetic characteristics and evolving molecular mechanisms

(2014) Temistocle Lo Giudice et al.   EXPERIMENTAL NEUROLOGY

GRAF1a is a brain-specific protein that promotes lipid droplet clustering and growth, and is enriched at lipid droplet junctions

(2014) S. Lucken-Ardjomande Hasler et al.   JOURNAL OF CELL SCIENCE

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Cell Survival during Complete Nutrient Deprivation Depends on Lipid Droplet-fueled β-Oxidation of Fatty Acids

(2013) Ainara G. Cabodevilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial Dysfunction Induces Formation of Lipid Droplets as a Generalized Response to Stress

(2013) Seon-Jin Lee et al.   Oxidative Medicine and Cellular Longevity

Greasing the synaptic vesicle cycle by membrane lipids

(2013) Dmytro Puchkov et al.   TRENDS IN CELL BIOLOGY

Lipid Droplets and Cellular Lipid Metabolism

(2012) Tobias C. Walther et al.   Annual Review of Biochemistry

Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia

(2012) Armen Khatchadourian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

Spg20−/− mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling

(2012) Benoît Renvoisé et al.   HUMAN MOLECULAR GENETICS

Emerging Roles for Lipid Droplets in Immunity and Host-Pathogen Interactions

(2011) Hector Alex Saka et al.   Annual Review of Cell and Developmental Biology

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Distinguishing Alzheimer’s disease from other major forms of dementia

(2011) Stella Karantzoulis et al.   Expert Review of Neurotherapeutics

N88S seipin mutant transgenic mice develop features of seipinopathy/BSCL2-related motor neuron disease via endoplasmic reticulum stress

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

Unique Regulation of Adipose Triglyceride Lipase (ATGL) by Perilipin 5, a Lipid Droplet-associated Protein

(2011) Hong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes

(2011) Charles A. Harris et al.   JOURNAL OF LIPID RESEARCH

Spartin recruits PKC-ζ via the PKC-ζ-interacting proteins ZIP1 and ZIP3 to lipid droplets

(2011) Andreas Urbanczyk et al.   JOURNAL OF NEUROCHEMISTRY

Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers

(2011) Karoline Etschmaier et al.   JOURNAL OF NEUROCHEMISTRY

Lipid body function in eicosanoid synthesis: An update

(2011) Patricia T. Bozza et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets

(2010) Christopher Hooper et al.   BMC BIOLOGY

Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer’s disease

(2010) Laura K. Hamilton et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood

(2010) M. Bouab et al.   NEUROSCIENCE

An update of MALDI-TOF mass spectrometry in lipid research

(2010) Beate Fuchs et al.   PROGRESS IN LIPID RESEARCH

Lipid droplets in inflammation and cancer

(2010) Patricia T. Bozza et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

(2009) Thomas L. Edwards et al.   BIOCHEMICAL JOURNAL

A role for lipid droplets in inter-membrane lipid traffic

(2009) John K. Zehmer et al.   PROTEOMICS

Starving Neurons Show Sex Difference in Autophagy

(2008) Lina Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging of lipid species by MALDI mass spectrometry

(2008) Robert C. Murphy et al.   JOURNAL OF LIPID RESEARCH

Cidea is associated with lipid droplets and insulin sensitivity in humans

(2008) V. Puri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA