Increasing Fatty Acid Oxidation Remodels the Hypothalamic Neurometabolome to Mitigate Stress and Inflammation

Differential Pharmacologic Properties of the Two C75 Enantiomers: (+)-C75 Is a Strong Anorectic Drug; (−)-C75 Has Antitumor Activity

(2013) Kamil Makowski et al.   CHIRALITY

Hypothalamic Ceramide Levels Regulated by CPT1C Mediate the Orexigenic Effect of Ghrelin

(2013) S. Ramirez et al.   DIABETES

Endoplasmic reticulum stress preconditioning attenuates methylmercury-induced cellular damage by inducing favorable stress responses

(2013) Fusako Usuki et al.   Scientific Reports

Stimulation of carnitine palmitoyltransferase 1 improves renal function and attenuates tissue damage after ischemia/reperfusion

(2012) Juan-Pablo Idrovo et al.   JOURNAL OF SURGICAL RESEARCH

Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease

(2012) Naim Alkhouri et al.   LIVER INTERNATIONAL

Unsaturated Fatty Acids Revert Diet-Induced Hypothalamic Inflammation in Obesity

(2012) Dennys E. Cintra et al.   PLoS One

Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity

(2011) Francis P. Kuhajda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

A Failure to Normalize Biochemical and Metabolic Insults During Morphine Withdrawal Disrupts Synaptic Repair in Mice Transgenic for HIV-gp120

(2011) Veera Venkata Ratnam Bandaru et al.   Journal of Neuroimmune Pharmacology

Physiological oxygen level is critical for modeling neuronal metabolism in vitro

(2011) Jing Zhu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

(2011) Sabrina Diano et al.   NATURE MEDICINE

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding

(2011) S. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids

(2010) Sun Ju Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

(2010) Eduardo R. Ropelle et al.   PLOS BIOLOGY

Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing

(2009) Christelle Le Foll et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Palmitate Attenuates Insulin Signaling and Induces Endoplasmic Reticulum Stress and Apoptosis in Hypothalamic Neurons: Rescue of Resistance and Apoptosis through Adenosine 5′ Monophosphate-Activated Protein Kinase Activation

(2009) Christopher M. Mayer et al.   ENDOCRINOLOGY

Design and Synthesis of Small Molecule Glycerol 3-Phosphate Acyltransferase Inhibitors

(2009) Edward A. Wydysh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Fatty acid oxidation and meiotic resumption in mouse oocytes

(2009) Stephen M. Downs et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin

(2009) Jong Chul Won et al.   Obesity

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight

(2008) Paula Mera et al.   BIOCHEMICAL PHARMACOLOGY

Glycerol-3-phosphate acyltransferases: Rate limiting enzymes of triacylglycerol biosynthesis

(2008) Angela A. Wendel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

Role of Mitochondrial Dysfunction in Insulin Resistance

(2008) Jeong-a Kim et al.   CIRCULATION RESEARCH

Hepatic triglyceride synthesis and nonalcoholic fatty liver disease

(2008) Steve S Choi et al.   CURRENT OPINION IN LIPIDOLOGY

AMPK: a key regulator of energy balance in the single cell and the whole organism

(2008) D G Hardie   INTERNATIONAL JOURNAL OF OBESITY

CPT1c Is Localized in Endoplasmic Reticulum of Neurons and Has Carnitine Palmitoyltransferase Activity

(2008) Adriana Y. Sierra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation

(2008) Manu V. Chakravarthy et al.   JOURNAL OF LIPID RESEARCH

Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight

(2007) Susan Aja et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro

(2007) Amy M. Kleman et al.   JOURNAL OF NEUROSCIENCE METHODS

Lipid accumulation in non-adipose tissue and lipotoxicity

(2007) N.A. van Herpen et al.   PHYSIOLOGY & BEHAVIOR