Killing SCLC: insights into how to target a shapeshifting tumor

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

(2021) Carl M. Gay et al.   CANCER CELL

Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis

(2021) Mingrui Zhu et al.   CANCER RESEARCH

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small-cell lung cancer

(2021) Charles M. Rudin et al.   Nature Reviews Disease Primers

Intrinsic immunogenicity of small cell lung carcinoma revealed by its cellular plasticity

(2021) Navin R. Mahadevan et al.   Cancer Discovery

Molecular profiles of small cell lung cancer subtypes: therapeutic implications

(2021) Anna Schwendenwein et al.   Molecular Therapy-Oncolytics

Molecular and Functional Links between Neurodevelopmental Processes and Treatment-Induced Neuroendocrine Plasticity in Prostate Cancer Progression

(2021) Roosa Kaarijärvi et al.   Cancers

Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer

(2021) Ling Cai et al.   Communications Biology

Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress

(2021) Anish Thomas et al.   CANCER CELL

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

(2021) Christina M. Bebber et al.   Nature Communications

Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer

(2021) Lakshya Chauhan et al.   eLife

ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer

(2021) Rachelle R. Olsen et al.   GENES & DEVELOPMENT

MAX mutant small-cell lung cancers exhibit impaired activities of MGA-dependent noncanonical polycomb repressive complex

(2021) Paula Llabata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer

(2021) Nitin Roper et al.   Nature Communications

Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer

(2021) Huaqiang Zhou et al.   Nature Communications

Rlf-Mycl gene fusion drives tumorigenesis and metastasis in a mouse model of small cell lung cancer

(2021) Metamia Ciampricotti et al.   Cancer Discovery

Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation

(2021) Alvaro Quintanal-Villalonga et al.   Cancer Discovery

Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

(2021) Yusuke Inoue et al.   eLife

Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer

(2021) Kasey R. Cargill et al.   Cancer & Metabolism

Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer

(2021) Joseph M. Chan et al.   CANCER CELL

Lung neuroendocrine neoplasms: recent progress and persistent challenges

(2021) Natasha Rekhtman   MODERN PATHOLOGY

Non-genetic determinants of malignant clonal fitness at single-cell resolution

(2021) Katie A. Fennell et al.   NATURE

Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium

(2021) Jasmine Chen et al.   ONCOGENE

Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

(2021) Paloma Cejas et al.   Nature Communications

Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer

(2021) Ming Chen et al.   Nature Communications

Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

(2021) Yujuan Jin et al.   National Science Review

YAP drives fate conversion and chemoresistance of small cell lung cancer

(2021) Qingzhe Wu et al.   Science Advances

MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer

(2021) Rebecca Caeser et al.   iScience

Transient Sox9 Expression Facilitates Progression to Castrate Resistant Prostate Cancer

(2020) Mannan Nouri et al.   CLINICAL CANCER RESEARCH

New Approaches to SCLC Therapy: From the Laboratory to the Clinic

(2020) John T. Poirier et al.   Journal of Thoracic Oncology

MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer

(2020) Arnaud Augert et al.   CANCER CELL

MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate

(2020) Abbie S. Ireland et al.   CANCER CELL

Harnessing natural killer immunity in metastatic small cell lung cancer

(2020) Sarah A. Best et al.   Journal of Thoracic Oncology

Lurbinectedin as second-line treatment for patients with small-cell lung cancer: a single-arm, open-label, phase 2 basket trial

(2020) José Trigo et al.   LANCET ONCOLOGY

MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression

(2020) Yuto Yasuda et al.   Cell Death & Disease

The rare YAP1 subtype of Small Cell Lung Cancer revisited in a biobank of 39 Circulating Tumour Cell Patient Derived eXplant models (CDX): A brief report

(2020) Sarah M. Pearsall et al.   Journal of Thoracic Oncology

Neuroendocrine subtypes of small cell lung cancer differ in terms of immune microenvironment and checkpoint molecule distribution

(2020) David Dora et al.   Molecular Oncology

The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis

(2020) Xiaomeng Zhang et al.   ONCOGENE

Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer

(2020) John R. Christin et al.   Cell Reports

MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity

(2020) Eli Grunblatt et al.   GENES & DEVELOPMENT

Small Cell Lung Carcinoma Subtypes Defined by ASCL1, NEUROD1, POU2F3 and YAP1: Comprehensive Immunohistochemical and Histopathologic Characterization

(2020) Marina K. Baine et al.   Journal of Thoracic Oncology

SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

(2020) Camille Tlemsani et al.   Cell Reports

FDA Approval Summary: Lurbinectedin for the Treatment of Metastatic Small Cell Lung Cancer

(2020) Sonia Singh et al.   CLINICAL CANCER RESEARCH

Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer

(2020) Fang Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

YAP1 Expression in SCLC Defines a Distinct Subtype With T-cell–Inflamed Phenotype

(2020) Taofeek K. Owonikoko et al.   Journal of Thoracic Oncology

The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters

(2019) Arnold J. Levine et al.   CANCER CELL

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

(2019) Triparna Sen et al.   Cancer Discovery

Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition

(2019) Arnaud Augert et al.   Science Signaling

First-Line Nivolumab Plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer (CheckMate 568): Outcomes by Programmed Death Ligand 1 and Tumor Mutational Burden as Biomarkers

(2019) Neal Ready et al.   JOURNAL OF CLINICAL ONCOLOGY

A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients

(2019) Joseph Cursons et al.   Cancer Immunology Research

MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion

(2019) Milind D. Chalishazar et al.   CLINICAL CANCER RESEARCH

DLL3: an emerging target in small cell lung cancer

(2019) Dwight H. Owen et al.   Journal of Hematology & Oncology

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

(2019) Marian L. Burr et al.   CANCER CELL

Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small Cell Lung Cancer: Results From the Phase II TRINITY Study

(2019) Daniel Morgensztern et al.   CLINICAL CANCER RESEARCH

Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch

(2019) Youcef Ouadah et al.   CELL

Notch signaling in the mammalian respiratory system, specifically the trachea and lungs, in development, homeostasis, regeneration, and disease

(2019) Hirofumi Kiyokawa et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis

(2019) Matthew G. Oser et al.   GENES & DEVELOPMENT

Randomized Phase II Study of Paclitaxel plus Alisertib versus Paclitaxel plus Placebo as Second-Line Therapy for SCLC: Primary and Correlative Biomarker Analyses

(2019) Taofeek K. Owonikoko et al.   Journal of Thoracic Oncology

Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial

(2019) Luis Paz-Ares et al.   LANCET

The great escape: tumour cell plasticity in resistance to targeted therapy

(2019) Soufiane Boumahdi et al.   NATURE REVIEWS DRUG DISCOVERY

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

(2019) Marcel A. Dammert et al.   Nature Communications

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

(2019) David J. Wooten et al.   PLoS Computational Biology

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

(2019) Hua Zhang et al.   CANCER CELL

Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer

(2018) Matthew D. Hellmann et al.   CANCER CELL

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

(2018) Fang Huang et al.   Cell Metabolism

POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer

(2018) Yu-Han Huang et al.   GENES & DEVELOPMENT

Crosstalk between YAP/TAZ and Notch Signaling

(2018) Antonio Totaro et al.   TRENDS IN CELL BIOLOGY

Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts

(2018) Benjamin J. Drapkin et al.   Cancer Discovery

Abstract 3709: Characterization, in vitro and in vivo efficacy studies of docetaxel trastuzumab stealth immunoliposome in human breast cancer models

(2018) Anne Rodallec et al.   CANCER RESEARCH

Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies

(2018) Alexander Muir et al.   Disease Models & Mechanisms

A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

(2018) Lindsey W. Plasschaert et al.   NATURE

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(2018) Daniel T. Montoro et al.   NATURE

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer

(2018) Leora Horn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

(2018) Alex H. Wagner et al.   Nature Communications

Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition

(2018) Deshui Jia et al.   Cancer Discovery

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

(2018) Yumeng Wang et al.   Cell Reports

Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus

(2017) Linde A. Miles et al.   JOURNAL OF CLINICAL INVESTIGATION

Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2 : CALGB 151111 (Alliance)

(2017) Arnaud Augert et al.   Journal of Thoracic Oncology

Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study

(2017) Charles M Rudin et al.   LANCET ONCOLOGY

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

(2017) Jing Shan Lim et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer

(2017) Karen McColl et al.   Oncotarget

Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies

(2017) Robert J. Cardnell et al.   Oncotarget

Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer

(2017) Fabian Doerr et al.   Scientific Reports

YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer

(2016) Masafumi Horie et al.   CANCER SCIENCE

Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility

(2016) Sarah K. Denny et al.   CELL

Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis

(2016) Hiromi Shimojo et al.   GENES & DEVELOPMENT

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

(2016) Kipp Weiskopf et al.   JOURNAL OF CLINICAL INVESTIGATION

Lung Cancer Subtypes Generate Unique Immune Responses

(2016) Stephanie E. Busch et al.   JOURNAL OF IMMUNOLOGY

Barasertib (AZD1152), a Small Molecule Aurora B Inhibitor, Inhibits the Growth of SCLC Cell Lines In Vitro and In Vivo

(2016) B. A. Helfrich et al.   MOLECULAR CANCER THERAPEUTICS

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

(2016) András Kotschy et al.   NATURE

Mutational signatures associated with tobacco smoking in human cancer

(2016) L. B. Alexandrov et al.   SCIENCE

Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network

(2016) Shuguo Sun et al.   TRENDS IN CELL BIOLOGY

Vasculogenic mimicry in small cell lung cancer

(2016) Stuart C. Williamson et al.   Nature Communications

NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer

(2016) Nan Wu et al.   Oncotarget

Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients

(2016) Ekaterina A. Semenova et al.   Cell Reports

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

(2016) Mark D. Borromeo et al.   Cell Reports

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer

(2016) Narsis Attar et al.   Cold Spring Harbor Perspectives in Medicine

Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer

(2015) Kosuke Fujino et al.   AMERICAN JOURNAL OF PATHOLOGY

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

(2015) Helai P. Mohammad et al.   CANCER CELL

Insm1 controls the differentiation of pulmonary neuroendocrine cells by repressing Hes1

(2015) Shiqi Jia et al.   DEVELOPMENTAL BIOLOGY

Paracrine signaling between tumor subclones of mouse SCLC: a critical role of ETS transcription factor Pea3 in facilitating metastasis

(2015) Min-chul Kwon et al.   GENES & DEVELOPMENT

Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin

(2015) Matthew G Oser et al.   LANCET ONCOLOGY

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2

(2015) J T Poirier et al.   ONCOGENE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

(2015) Laura R. Saunders et al.   Science Translational Medicine

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer

(2015) Matthew J. Niederst et al.   Nature Communications

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

(2014) Camilla L. Christensen et al.   CANCER CELL

Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing

(2014) David G. McFadden et al.   CELL

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

(2014) Sudha Mannava et al.   CELL CYCLE

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells

(2014) Ivo J Huijbers et al.   EMBO Molecular Medicine

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

(2014) A. Augustyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Tropism of Seneca Valley Virus for Variant Subtype Small Cell Lung Cancer

(2013) J. T. Poirier et al.   JNCI-Journal of the National Cancer Institute

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM

(2013) J. K. Osborne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAX Inactivation in Small Cell Lung Cancer Disrupts MYC-SWI/SNF Programs and Is Synthetic Lethal with BRG1

(2013) O. A. Romero et al.   Cancer Discovery

PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer

(2013) Teruyuki Sato et al.   Scientific Reports

An Integrated Genomic Approach to Identify Predictive Biomarkers of Response to the Aurora Kinase Inhibitor PF-03814735

(2012) K. E. Hook et al.   MOLECULAR CANCER THERAPEUTICS

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

(2012) Charles M Rudin et al.   NATURE GENETICS

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

(2012) Martin Peifer et al.   NATURE GENETICS

A framework for identification of actionable cancer genome dependencies in small cell lung cancer

(2012) M. L. Sos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer

(2011) Joaquim Calbo et al.   CANCER CELL

Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

(2011) Kate D. Sutherland et al.   CANCER CELL

Characterization of the cell of origin for small cell lung cancer

(2011) Kwon-Sik Park et al.   CELL CYCLE

Nuclear factor I/B is an oncogene in small cell lung cancer

(2011) A. L. Dooley et al.   GENES & DEVELOPMENT

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

(2010) Qihuang Jin et al.   EMBO JOURNAL

Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate

(2010) M. Morimoto et al.   JOURNAL OF CELL SCIENCE

Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development

(2009) Branden R. Nelson et al.   DEVELOPMENTAL DYNAMICS

A small-cell lung cancer genome with complex signatures of tobacco exposure

(2009) Erin D. Pleasance et al.   NATURE

Targeted Disruption of NeuroD, a Proneural Basic Helix-Loop-Helix Factor, Impairs Distal Lung Formation and Neuroendocrine Morphology in the Neonatal Lung

(2008) Enid R. Neptune et al.   JOURNAL OF BIOLOGICAL CHEMISTRY