Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

(2021) Carl M. Gay et al.   CANCER CELL

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

SciPy 1.0: fundamental algorithms for scientific computing in Python

(2020) Pauli Virtanen et al.   NATURE METHODS

CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

(2020) Mirjana Efremova et al.   Nature Protocols

MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate

(2020) Abbie S. Ireland et al.   CANCER CELL

Harnessing natural killer immunity in metastatic small cell lung cancer

(2020) Sarah A. Best et al.   Journal of Thoracic Oncology

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer

(2020) Mariela A. Moreno Ayala et al.   Scientific Reports

Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer

(2020) Omar Elakad et al.   Cancer Medicine

Cells of origin of lung cancers: lessons from mouse studies

(2020) Giustina Ferone et al.   GENES & DEVELOPMENT

The rare YAP1 subtype of Small Cell Lung Cancer revisited in a biobank of 39 Circulating Tumour Cell Patient Derived eXplant models (CDX): A brief report

(2020) Sarah M. Pearsall et al.   Journal of Thoracic Oncology

Neuroendocrine subtypes of small cell lung cancer differ in terms of immune microenvironment and checkpoint molecule distribution

(2020) David Dora et al.   Molecular Oncology

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

(2020) Taylor S. Adams et al.   Science Advances

Small Cell Lung Carcinoma Subtypes Defined by ASCL1, NEUROD1, POU2F3 and YAP1: Comprehensive Immunohistochemical and Histopathologic Characterization

(2020) Marina K. Baine et al.   Journal of Thoracic Oncology

Array programming with NumPy

(2020) Charles R. Harris et al.   NATURE

Concepts of extracellular matrix remodelling in tumour progression and metastasis

(2020) Juliane Winkler et al.   Nature Communications

Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers

(2020) Daniel L Morris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

YAP1 Expression in SCLC Defines a Distinct Subtype With T-cell–Inflamed Phenotype

(2020) Taofeek K. Owonikoko et al.   Journal of Thoracic Oncology

Axonogenesis Is Coordinated by Neuron-Specific Alternative Splicing Programming and Splicing Regulator PTBP2

(2019) Min Zhang et al.   NEURON

De novo gene signature identification from single‐cell RNA‐seq with hierarchical Poisson factorization

(2019) Hanna Mendes Levitin et al.   Molecular Systems Biology

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

(2019) Sven J. van der Lee et al.   ACTA NEUROPATHOLOGICA

FGFR1 Cooperates with EGFR in Lung Cancer Oncogenesis, and Their Combined Inhibition Shows Improved Efficacy

(2019) Alvaro Quintanal-Villalonga et al.   Journal of Thoracic Oncology

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

(2019) Christopher S. Smillie et al.   CELL

MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion

(2019) Milind D. Chalishazar et al.   CLINICAL CANCER RESEARCH

A human liver cell atlas reveals heterogeneity and epithelial progenitors

(2019) Nadim Aizarani et al.   NATURE

Identification of SPP1 as an Extracellular Matrix Signature for Metastatic Castration-Resistant Prostate Cancer

(2019) Xiaocong Pang et al.   Frontiers in Oncology

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial

(2019) Luis Paz-Ares et al.   LANCET

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

(2019) David J. Wooten et al.   PLoS Computational Biology

Up-regulated fibronectin in 3D culture facilitates spreading of triple negative breast cancer cells on 2D through integrin β-5 and Src

(2019) Hwa -Jeong Park et al.   Scientific Reports

Axon-like protrusions promote small cell lung cancer migration and metastasis

(2019) Dian Yang et al.   eLife

Recovering Gene Interactions from Single-Cell Data Using Data Diffusion

(2018) David van Dijk et al.   CELL

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

(2018) Elham Azizi et al.   CELL

Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors

(2018) Laleh Haghverdi et al.   NATURE BIOTECHNOLOGY

Blockade of MIF–CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma

(2018) Carlos R. Figueiredo et al.   Frontiers in Immunology

The Dual Role of Bone Morphogenetic Proteins in Cancer

(2018) Duc-Hiep Bach et al.   Molecular Therapy-Oncolytics

A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging

(2018) Leeat Keren et al.   CELL

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(2018) Daniel T. Montoro et al.   NATURE

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer

(2018) Leora Horn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enter the Matrix: Factorization Uncovers Knowledge from Omics

(2018) Genevieve L. Stein-O’Brien et al.   TRENDS IN GENETICS

Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells

(2018) Dusan Hrckulak et al.   Genes

Osteopontin controls immunosuppression in the tumor microenvironment

(2018) Michael R. Shurin   JOURNAL OF CLINICAL INVESTIGATION

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease

(2017) Shinya Kusakari et al.   JOURNAL OF NEUROCHEMISTRY

Unravelling the biology of SCLC: implications for therapy

(2017) Joshua K. Sabari et al.   Nature Reviews Clinical Oncology

Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer

(2017) Woosung Chung et al.   Nature Communications

Fibronectin: How Its Aberrant Expression in Tumors May Improve Therapeutic Targeting

(2017) Jennifer Peyling Wang et al.   Journal of Cancer

Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

(2017) Erika Castillo et al.   Scientific Reports

The TissueNet v.2 database: A quantitative view of protein-protein interactions across human tissues

(2016) Omer Basha et al.   NUCLEIC ACIDS RESEARCH

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

(2016) Mark D. Borromeo et al.   Cell Reports

Tcf4 Controls Neuronal Migration of the Cerebral Cortex through Regulation of Bmp7

(2016) Tianda Chen et al.   Frontiers in Molecular Neuroscience

Tumor-derived osteopontin isoforms cooperate with TRP53 and CCL2 to promote lung metastasis

(2016) Ioanna Giopanou et al.   OncoImmunology

The ratio of CD8 to Treg tumor-infiltrating lymphocytes is associated with response to cisplatin-based neoadjuvant chemotherapy in patients with muscle invasive urothelial carcinoma of the bladder

(2016) Alexander S. Baras et al.   OncoImmunology

Clinical and prognostic significance of OPN and VEGF expression in patients with non-small-cell lung cancer

(2015) Qunying Lin et al.   Cancer Epidemiology

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

(2015) Jacob H. Levine et al.   CELL

Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT)

(2015) Donavan T. Cheng et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2

(2015) J T Poirier et al.   ONCOGENE

A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

(2015) Laura R. Saunders et al.   Science Translational Medicine

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

(2015) Bin Shang et al.   Scientific Reports

Small cell lung cancer: Where do we go from here?

(2014) Lauren Averett Byers et al.   CANCER

Zac1 Regulates Cell Cycle Arrest in Neuronal Progenitors via Tcf4

(2014) U. Schmidt-Edelkraut et al.   MOLECULAR AND CELLULAR BIOLOGY

EZH2 Promotes E2F-Driven SCLC Tumorigenesis through Modulation of Apoptosis and Cell-Cycle Regulation

(2013) Roland Hubaux et al.   Journal of Thoracic Oncology

The Ratios of CD8+ T Cells to CD4+CD25+ FOXP3+ and FOXP3- T Cells Correlate with Poor Clinical Outcome in Human Serous Ovarian Cancer

(2013) Claudia C. Preston et al.   PLoS One

Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition

(2012) D. Gao et al.   CANCER RESEARCH

Estimation of Nonlinear Functionals of Densities With Confidence

(2012) Kumar Sricharan et al.   IEEE TRANSACTIONS ON INFORMATION THEORY

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

(2012) Charles M Rudin et al.   NATURE GENETICS

Semaphorin Signaling in Vertebrate Neural Circuit Assembly

(2012) Yutaka Yoshida   Frontiers in Molecular Neuroscience

Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial–mesenchymal transition and cancer stem cell properties

(2011) S M Farabaugh et al.   ONCOGENE

Kernel density estimation via diffusion

(2010) Z. I. Botev et al.   ANNALS OF STATISTICS

TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion

(2010) Y Wu et al.   BRITISH JOURNAL OF CANCER

Eph/ephrin molecules--a hub for signaling and endocytosis

(2010) M. E. Pitulescu et al.   GENES & DEVELOPMENT

The IASLC Lung Cancer Staging Project: Proposals Regarding the Relevance of TNM in the Pathologic Staging of Small Cell Lung Cancer in the Forthcoming (Seventh) Edition of the TNM Classification for Lung Cancer

(2010) Eric Vallières et al.   Journal of Thoracic Oncology

Phospholipase C 1 Is Required for Metastasis Development and Progression

(2008) G. Sala et al.   CANCER RESEARCH