Molecular and Functional Links between Neurodevelopmental Processes and Treatment-Induced Neuroendocrine Plasticity in Prostate Cancer Progression

Clinical and Biological Features of Neuroendocrine Prostate Cancer

(2021) Yasutaka Yamada et al.   Current Oncology Reports

WLS-Wnt signaling promotes neuroendocrine prostate cancer

(2021) Tyler Bland et al.   iScience

FOXM1: a potential therapeutic target in human solid cancers

(2020) Soheila Borhani et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer

(2020) Himisha Beltran et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of p53 drives neuron reprogramming in head and neck cancer

(2020) Moran Amit et al.   NATURE

Tumour innervation and neurosignalling in prostate cancer

(2020) Brayden March et al.   Nature Reviews Urology

MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer

(2020) Yota Yasumizu et al.   Nature Communications

Cancer cell’s neuroendocrine feature can be acquired through cell-cell fusion during cancer-neural stem cell interaction

(2020) Liyuan Yin et al.   Scientific Reports

Roadmap for the Emerging Field of Cancer Neuroscience

(2020) Michelle Monje et al.   CELL

The SWI/SNF complex in cancer — biology, biomarkers and therapy

(2020) Priya Mittal et al.   Nature Reviews Clinical Oncology

Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model

(2020) Vincent Faugeroux et al.   Nature Communications

Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress

(2020) Michael D. Nyquist et al.   Cell Reports

Clinical Features of Treatment-related Neuroendocrine Prostate Cancer: A Case Series

(2020) KOTARO SUZUKI et al.   ANTICANCER RESEARCH

Conditionally Reprogrammed Cells from Patient-Derived Xenograft to Model Neuroendocrine Prostate Cancer Development

(2020) Xinpei Ci et al.   Cells

Androgen Deprivation Induces Reprogramming of Prostate Cancer Cells to Stem-Like Cells

(2020) Belén G. Sánchez et al.   Cells

De novo induction of lineage plasticity from human prostate luminal epithelial cells by activated AKT1 and c-Myc

(2020) Oh-Joon Kwon et al.   ONCOGENE

MUC1-C ACTIVATES THE BAF (mSWI/SNF) COMPLEX IN PROSTATE CANCER STEM CELLS

(2020) Masayuki Hagiwara et al.   CANCER RESEARCH

Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

(2020) Baijun Dong et al.   Communications Biology

ONECUT2 is a driver of neuroendocrine prostate cancer

(2019) Haiyang Guo et al.   Nature Communications

CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells

(2019) Kai Härkönen et al.   Cells

ADRB2-Targeting Therapies for Prostate Cancer

(2019) George Kulik   Cancers

Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer

(2019) Shimiao Zhu et al.   ONCOGENE

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

(2019) Miguel Reina-Campos et al.   CANCER CELL

Characterization of Transcriptomic signature of primary prostate cancer analogous to prostatic small cell neuroendocrine carcinoma

(2019) Mohammed Alshalalfa et al.   INTERNATIONAL JOURNAL OF CANCER

Progenitors from the central nervous system drive neurogenesis in cancer

(2019) Philippe Mauffrey et al.   NATURE

PEG10 is associated with treatment-induced neuroendocrine prostate cancer

(2019) Soojin Kim et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

(2019) William Farnaby et al.   Nature Chemical Biology

Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer

(2019) Alexander Kretschmer et al.   Scientific Reports

The β2-Adrenergic Receptor Is a Molecular Switch for Neuroendocrine Transdifferentiation of Prostate Cancer Cells

(2019) Peder R. Braadland et al.   MOLECULAR CANCER RESEARCH

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport

(2019) Evgeny Shlevkov et al.   Cell Reports

SOX2 has dual functions as a regulator in the progression of neuroendocrine prostate cancer

(2019) Haiying Li et al.   LABORATORY INVESTIGATION

Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study

(2018) Rahul Aggarwal et al.   JOURNAL OF CLINICAL ONCOLOGY

Biallelic tumor suppressor loss and DNA repair defects in de novo small cell prostate cancer

(2018) Edmund CP Chedgy et al.   JOURNAL OF PATHOLOGY

Cellular plasticity and the neuroendocrine phenotype in prostate cancer

(2018) Alastair H. Davies et al.   Nature Reviews Urology

MUC1-C activates polycomb repressive complexes and downregulates tumor suppressor genes in human cancer cells

(2018) Hasan Rajabi et al.   ONCOGENE

Brn2 Alone Is Sufficient to Convert Astrocytes into Neural Progenitors and Neurons

(2018) Xiaoqing Zhu et al.   STEM CELLS AND DEVELOPMENT

Direct Reprogramming of Adult Human Somatic Stem Cells Into Functional Neurons Using Sox2, Ascl1, and Neurog2

(2018) Jessica Alves de Medeiros Araújo et al.   Frontiers in Cellular Neuroscience

Nuclear loss and cytoplasmic expression of androgen receptor in penile carcinomas: role as a driver event and as a prognosis factor

(2018) Hellen Kuasne et al.   VIRCHOWS ARCHIV

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

(2018) Julien P. N. Papillon et al.   JOURNAL OF MEDICINAL CHEMISTRY

ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis

(2018) Mirja Rotinen et al.   NATURE MEDICINE

A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies

(2017) Ankit C. Borisa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SRRM4 Drives Neuroendocrine Transdifferentiation of Prostate Adenocarcinoma Under Androgen Receptor Pathway Inhibition

(2017) Yinan Li et al.   EUROPEAN UROLOGY

Subcellular localisation of the stem cell markers OCT4, SOX2, NANOG, KLF4 and c-MYC in cancer: a review

(2017) Bede van Schaijik et al.   JOURNAL OF CLINICAL PATHOLOGY

FOXA1 inhibits prostate cancer neuroendocrine differentiation

(2017) J Kim et al.   ONCOGENE

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 - and RB1 -deficient prostate cancer

(2017) Ping Mu et al.   SCIENCE

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

(2017) Sheng Yu Ku et al.   SCIENCE

Implications of PI3K/AKT inhibition on REST protein stability and neuroendocrine phenotype acquisition in prostate cancer cells

(2017) Ruiqui Chen et al.   Oncotarget

The EZH2 inhibitor GSK343 suppresses cancer stem-like phenotypes and reverses mesenchymal transition in glioma cells

(2017) Tianfu Yu et al.   Oncotarget

Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance

(2017) Mannan Nouri et al.   Oncotarget

A Wnt/Calcium Signaling Cascade Regulates Neuronal Excitability and Trafficking of NMDARs

(2017) Andrea McQuate et al.   Cell Reports

Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide resistant prostate cancer

(2017) Jianneng Li et al.   eLife

Androgen Receptor-Dependent and -Independent Mechanisms Involved in Prostate Cancer Therapy Resistance

(2017) Daniel Crona et al.   Cancers

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer

(2016) Etienne Dardenne et al.   CANCER CELL

The importance of non-nuclear AR signaling in prostate cancer progression and therapeutic resistance

(2016) Jelani C. Zarif et al.   CELLULAR SIGNALLING

The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma

(2016) W. Li et al.   MOLECULAR CANCER RESEARCH

Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

(2016) Himisha Beltran et al.   NATURE MEDICINE

The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer

(2016) Jennifer L. Bishop et al.   Cancer Discovery

GRK3 is a direct target of CREB activation and regulates neuroendocrine differentiation of prostate cancer cells

(2016) Meixiang Sang et al.   Oncotarget

FOXM1 in sarcoma: role in cell cycle, pluripotency genes and stem cell pathways

(2016) Fergal C. Kelleher et al.   Oncotarget

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

(2016) Mark D. Borromeo et al.   Cell Reports

The missing link: does tunnelling nanotube-based supercellularity provide a new understanding of chronic and lifestyle diseases?

(2016) Amin Rustom   Open Biology

Regulation of tumor cell plasticity by the androgen receptor in prostate cancer

(2015) J. L. Bishop et al.   ENDOCRINE-RELATED CANCER

Molecular Characterization of Enzalutamide-treated Bone Metastatic Castration-resistant Prostate Cancer

(2015) Eleni Efstathiou et al.   EUROPEAN UROLOGY

Schwann Cells Increase Prostate and Pancreatic Tumor Cell Invasion Using Laminin Binding A6 Integrin

(2015) Isis C. Sroka et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity

(2015) Fuchun Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis

(2015) Alejandro Amador-Arjona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD44: molecular interactions, signaling and functions in the nervous system

(2015) Joanna Dzwonek et al.   Frontiers in Cellular Neuroscience

The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer

(2015) Shusuke Akamatsu et al.   Cell Reports

Ascl1 Coordinately Regulates Gene Expression and the Chromatin Landscape during Neurogenesis

(2015) Alexandre A.S.F. Raposo et al.   Cell Reports

β-Adrenergic Receptor Signaling in Prostate Cancer

(2015) Peder Rustøen Braadland et al.   Frontiers in Oncology

Prostate Cancer and Neuroendocrine Differentiation: More Neuronal, Less Endocrine?

(2015) Alexandru Dan Grigore et al.   Frontiers in Oncology

Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming

(2015) Radhika Arasala Rao et al.   Scientific Reports

Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate Cancer

(2015) Juan Miguel Mosquera et al.   NEOPLASIA

Aggressive Variants of Castration-Resistant Prostate Cancer

(2014) H. Beltran et al.   CLINICAL CANCER RESEARCH

MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division

(2014) N. Zinin et al.   EMBO REPORTS

The orexin type 1 receptor is overexpressed in advanced prostate cancer with a neuroendocrine differentiation, and mediates apoptosis

(2014) David Alexandre et al.   EUROPEAN JOURNAL OF CANCER

A Global Regulatory Mechanism for Activating an Exon Network Required for Neurogenesis

(2014) Bushra Raj et al.   MOLECULAR CELL

Onecut1 and Onecut2 Play Critical Roles in the Development of the Mouse Retina

(2014) Jillian J. Goetz et al.   PLoS One

Interleukin-6 induces neuroendocrine differentiation (NED) through suppression of RE-1 silencing transcription factor (REST)

(2014) Yezi Zhu et al.   PROSTATE

MUC1: a multifaceted oncoprotein with a key role in cancer progression

(2014) Sritama Nath et al.   TRENDS IN MOLECULAR MEDICINE

Enhancing adult nerve regeneration through the knockdown of retinoblastoma protein

(2014) Kimberly J. Christie et al.   Nature Communications

Glucocorticoid Receptor Activity Contributes to Resistance to Androgen-Targeted Therapy in Prostate Cancer

(2014) Masis Isikbay et al.   Hormones & Cancer

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

(2013) Orly L. Wapinski et al.   CELL

Proneural genes in neocortical development

(2013) G. Wilkinson et al.   NEUROSCIENCE

REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer

(2013) C. Svensson et al.   NUCLEIC ACIDS RESEARCH

POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer

(2013) Jun Ishii et al.   PATHOLOGY INTERNATIONAL

Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation

(2013) M Leibinger et al.   Cell Death & Disease

SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State

(2013) Michael A. Lodato et al.   PLoS Genetics

Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells

(2013) Deborah A Sanders et al.   GENOME BIOLOGY

Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress

(2012) K Ketola et al.   BRITISH JOURNAL OF CANCER

POU-III Transcription Factors (Brn1, Brn2, and Oct6) Influence Neurogenesis, Molecular Identity, and Migratory Destination of Upper-Layer Cells of the Cerebral Cortex

(2012) Martin H. Dominguez et al.   CEREBRAL CORTEX

Challenges in Recognizing Treatment-Related Neuroendocrine Prostate Cancer

(2012) Himisha Beltran et al.   JOURNAL OF CLINICAL ONCOLOGY

Activation of Aurora-A Is Essential for Neuronal Migration via Modulation of Microtubule Organization

(2012) T. Takitoh et al.   JOURNAL OF NEUROSCIENCE

Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer

(2012) Chunxiao Wu et al.   JOURNAL OF PATHOLOGY

MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches

(2012) D W Kufe   ONCOGENE

Chemical Biology Drug Sensitivity Screen Identifies Sunitinib as Synergistic Agent with Disulfiram in Prostate Cancer Cells

(2012) Kirsi Ketola et al.   PLoS One

Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis

(2012) H.-Y. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells

(2012) E. Lujan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Pathways: Beta-Adrenergic Signaling in Cancer: Figure 1.

(2011) Steven W. Cole et al.   CLINICAL CANCER RESEARCH

The Extended Granin Family: Structure, Function, and Biomedical Implications

(2011) Alessandro Bartolomucci et al.   ENDOCRINE REVIEWS

A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets

(2011) D. S. Castro et al.   GENES & DEVELOPMENT

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Using β-blockers to inhibit breast cancer progression

(2011) Desmond G. Powe et al.   Nature Reviews Clinical Oncology

Macrophages induce neuroendocrine differentiation of prostate cancer cells via BMP6-IL6 Loop

(2011) Geun Taek Lee et al.   PROSTATE

Understanding the Lethal Variant of Prostate Cancer: Power of Examining Extremes

(2011) A. Aparicio et al.   Cancer Discovery

Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets

(2011) H. Beltran et al.   Cancer Discovery

CREB: a multifaceted regulator of neuronal plasticity and protection

(2010) Kensuke Sakamoto et al.   JOURNAL OF NEUROCHEMISTRY

Monensin Is a Potent Inducer of Oxidative Stress and Inhibitor of Androgen Signaling Leading to Apoptosis in Prostate Cancer Cells

(2010) K. Ketola et al.   MOLECULAR CANCER THERAPEUTICS

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

(2010) J. D. Pereira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Vertebrate Nervous System Alternative Splicing and Development by an SR-Related Protein

(2009) John A. Calarco et al.   CELL

High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth

(2009) K. Iljin et al.   CLINICAL CANCER RESEARCH

An essential role of the aPKC–Aurora A–NDEL1 pathway in neurite elongation by modulation of microtubule dynamics

(2009) Daisuke Mori et al.   NATURE CELL BIOLOGY

Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh

(2009) Rebecca Favaro et al.   NATURE NEUROSCIENCE

Considering the evolution of regeneration in the central nervous system

(2009) Elly M. Tanaka et al.   NATURE REVIEWS NEUROSCIENCE

Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development

(2009) C. Francius et al.   NEUROSCIENCE

Pro-neural transcription factors as cancer markers

(2008) Maria Vias et al.   BMC Medical Genomics

Cancer-Related Axonogenesis and Neurogenesis in Prostate Cancer

(2008) G. E. Ayala et al.   CLINICAL CANCER RESEARCH

FoxM1-driven cell division is required for neuronal differentiation in early Xenopus embryos

(2008) H. Ueno et al.   DEVELOPMENT

CD44 expression is a feature of prostatic small cell Carcinoma and Distinguishes it from its Mimickers

(2008) Rochelle A. Simon et al.   HUMAN PATHOLOGY

Human ASH1 expression in prostate cancer with neuroendocrine differentiation

(2008) Ida Rapa et al.   MODERN PATHOLOGY

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

(2008) Thomas F. Westbrook et al.   NATURE