MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity

New Approaches to SCLC Therapy: From the Laboratory to the Clinic

(2020) John T. Poirier et al.   Journal of Thoracic Oncology

Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity

(2020) Paul R. Leger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition

(2019) Arnaud Augert et al.   Science Signaling

Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer

(2019) Franziska Böttger et al.   Cell Reports

Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial

(2019) Luis Paz-Ares et al.   LANCET

Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T Cell Receptors in High-riskMYCN-not-amplified Human Neuroblastoma

(2018) Jun S. Wei et al.   CLINICAL CANCER RESEARCH

The combination of the PARP inhibitor olaparib and the Wee1 inhibitor AZD1775 as a new therapeutic option for small cell lung cancer

(2018) Alice Lallo et al.   CLINICAL CANCER RESEARCH

Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts

(2018) Benjamin J. Drapkin et al.   Cancer Discovery

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer

(2018) Leora Horn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

(2018) Alex H. Wagner et al.   Nature Communications

A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence

(2017) Nan Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2 : CALGB 151111 (Alliance)

(2017) Arnaud Augert et al.   Journal of Thoracic Oncology

Neutrophils dominate the immune cell composition in non-small cell lung cancer

(2017) Julia Kargl et al.   Nature Communications

JQ1 synergizes with the Bcl-2 inhibitor ABT-263 against MYCN-amplified small cell lung cancer

(2017) Huogang Wang et al.   Oncotarget

An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

(2017) Peter J Skene et al.   eLife

MYCN Amplification Is Associated with Repressed Cellular Immunity in Neuroblastoma: An In Silico Immunological Analysis of TARGET Database

(2017) Peng Zhang et al.   Frontiers in Immunology

MYCN is an immunosuppressive oncogene dampening the expression of ligands for NK-cell-activating receptors in human high-risk neuroblastoma

(2017) Elisa Brandetti et al.   OncoImmunology

Genetic requirement forMycland efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer

(2016) Dong-Wook Kim et al.   GENES & DEVELOPMENT

Lung Cancer Subtypes Generate Unique Immune Responses

(2016) Stephanie E. Busch et al.   JOURNAL OF IMMUNOLOGY

HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma

(2016) Omid Tavana et al.   NATURE MEDICINE

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells

(2016) Fuyumi Kato et al.   Oncotarget

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

(2016) Mark D. Borromeo et al.   Cell Reports

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression

(2015) R. Lenhart et al.   MOLECULAR CANCER THERAPEUTICS

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

(2015) Henry E. Pelish et al.   NATURE

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells

(2014) Ivo J Huijbers et al.   EMBO Molecular Medicine

The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential

(2014) Himisha Beltran   MOLECULAR CANCER RESEARCH

Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer

(2014) Cassandra L Hodgkinson et al.   NATURE MEDICINE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Carboplatin- or Cisplatin-Based Chemotherapy in First-Line Treatment of Small-Cell Lung Cancer: The COCIS Meta-Analysis of Individual Patient Data

(2012) Antonio Rossi et al.   JOURNAL OF CLINICAL ONCOLOGY

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

(2012) Charles M Rudin et al.   NATURE GENETICS

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

(2012) Martin Peifer et al.   NATURE GENETICS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

(2011) Kate D. Sutherland et al.   CANCER CELL

A public genome-scale lentiviral expression library of human ORFs

(2011) Xiaoping Yang et al.   NATURE METHODS

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

(2010) Alexander Lachmann et al.   BIOINFORMATICS

Loss of p130 Accelerates Tumor Development in a Mouse Model for Human Small-Cell Lung Carcinoma

(2010) B. E. Schaffer et al.   CANCER RESEARCH

Pleiotropic role for MYCN in medulloblastoma

(2010) F. J. Swartling et al.   GENES & DEVELOPMENT

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture In vitro

(2009) V. C. Daniel et al.   CANCER RESEARCH

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

(2009) Michel DuPage et al.   Nature Protocols

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY