Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress

BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers

(2020) Florence Coussy et al.   Science Translational Medicine

Lurbinectedin as second-line treatment for patients with small-cell lung cancer: a single-arm, open-label, phase 2 basket trial

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Lineage plasticity in cancer: a shared pathway of therapeutic resistance

(2020) Álvaro Quintanal-Villalonga et al.   Nature Reviews Clinical Oncology

SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

(2020) Camille Tlemsani et al.   Cell Reports

Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies

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Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

(2019) Anna F. Farago et al.   Cancer Discovery

Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening

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Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids

(2019) N. Alcala et al.   Nature Communications

A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes

(2019) Liang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

INSM1 is a Sensitive and Specific Marker of Neuroendocrine Differentiation in Head and Neck Tumors

(2018) Lisa M. Rooper et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Phase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors

(2018) Anish Thomas et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized, Double-Blind, Phase II Study of Temozolomide in Combination With Either Veliparib or Placebo in Patients With Relapsed-Sensitive or Refractory Small-Cell Lung Cancer

(2018) M. Catherine Pietanza et al.   JOURNAL OF CLINICAL ONCOLOGY

SLFN11 Blocks Stressed Replication Forks Independently of ATR

(2018) Junko Murai et al.   MOLECULAR CELL

Characteristics and Outcomes of Small Cell Lung Cancer Detected by CT Screening

(2018) Anish Thomas et al.   CHEST

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer

(2018) Leora Horn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

(2018) Alex H. Wagner et al.   Nature Communications

ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells

(2017) Stephanie A. Yazinski et al.   GENES & DEVELOPMENT

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 - and RB1 -deficient prostate cancer

(2017) Ping Mu et al.   SCIENCE

Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer

(2016) Liyan Jiang et al.   CHEST

Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

(2016) Himisha Beltran et al.   NATURE MEDICINE

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

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FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing

(2016) Ronglai Shen et al.   NUCLEIC ACIDS RESEARCH

Small cell lung cancer: Time to revisit DNA-damaging chemotherapy

(2016) Anish Thomas et al.   Science Translational Medicine

Increased global transcription activity as a mechanism of replication stress in cancer

(2016) Panagiotis Kotsantis et al.   Nature Communications

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

(2016) Chris T. Williamson et al.   Nature Communications

Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage

(2016) Cosetta Bertoli et al.   Cell Reports

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

(2016) Mark D. Borromeo et al.   Cell Reports

Targeting DNA Replication Stress for Cancer Therapy

(2016) Jun Zhang et al.   Genes

Origins, genetic landscape, and emerging therapies of small cell lung cancer

(2015) Ekaterina A. Semenova et al.   GENES & DEVELOPMENT

Will Targeting Chk1 Have a Role in the Future of Cancer Therapy?

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Sunitinib in patients with chemotherapy-refractory thymoma and thymic carcinoma: an open-label phase 2 trial

(2015) Anish Thomas et al.   LANCET ONCOLOGY

Topotecan for Relapsed Small-cell Lung Cancer: Systematic Review and Meta-Analysis of 1347 Patients

(2015) Nobuyuki Horita et al.   Scientific Reports

Gene network-based analysis identifies two potential subtypes of small intestinal neuroendocrine tumors

(2014) Mark Kidd et al.   BMC GENOMICS

ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses

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DNA Replication and Oncogene-Induced Replicative Stress

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OpenComet: An automated tool for comet assay image analysis

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GSVA: gene set variation analysis for microarray and RNA-Seq data

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(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer

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Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1

(2013) Bunsyo Shiotani et al.   Cell Reports

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

(2012) Martin A.M. Reijns et al.   CELL

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

(2012) Charles M Rudin et al.   NATURE GENETICS

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Hallmarks of Cancer: The Next Generation

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Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

(2011) Matilde Murga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

(2011) Luis I Toledo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fast and accurate long-read alignment with Burrows–Wheeler transform

(2010) Heng Li et al.   BIOINFORMATICS

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

(2009) Sandie Tuduri et al.   NATURE CELL BIOLOGY

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER

An Oncogene-Induced DNA Damage Model for Cancer Development

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