标题
Killing SCLC: insights into how to target a shapeshifting tumor
作者
关键词
-
出版物
GENES & DEVELOPMENT
Volume 36, Issue 5-6, Pages 241-258
出版商
Cold Spring Harbor Laboratory
发表日期
2022-03-23
DOI
10.1101/gad.349359.122
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities
- (2021) Carl M. Gay et al. CANCER CELL
- Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis
- (2021) Mingrui Zhu et al. CANCER RESEARCH
- Ferroptosis: mechanisms, biology and role in disease
- (2021) Xuejun Jiang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Small-cell lung cancer
- (2021) Charles M. Rudin et al. Nature Reviews Disease Primers
- Intrinsic immunogenicity of small cell lung carcinoma revealed by its cellular plasticity
- (2021) Navin R. Mahadevan et al. Cancer Discovery
- Molecular profiles of small cell lung cancer subtypes: therapeutic implications
- (2021) Anna Schwendenwein et al. Molecular Therapy-Oncolytics
- Molecular and Functional Links between Neurodevelopmental Processes and Treatment-Induced Neuroendocrine Plasticity in Prostate Cancer Progression
- (2021) Roosa Kaarijärvi et al. Cancers
- Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer
- (2021) Ling Cai et al. Communications Biology
- Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
- (2021) Anish Thomas et al. CANCER CELL
- Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
- (2021) Christina M. Bebber et al. Nature Communications
- Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer
- (2021) Lakshya Chauhan et al. eLife
- ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer
- (2021) Rachelle R. Olsen et al. GENES & DEVELOPMENT
- MAX mutant small-cell lung cancers exhibit impaired activities of MGA-dependent noncanonical polycomb repressive complex
- (2021) Paula Llabata et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer
- (2021) Nitin Roper et al. Nature Communications
- Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer
- (2021) Huaqiang Zhou et al. Nature Communications
- Rlf-Mycl gene fusion drives tumorigenesis and metastasis in a mouse model of small cell lung cancer
- (2021) Metamia Ciampricotti et al. Cancer Discovery
- Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation
- (2021) Alvaro Quintanal-Villalonga et al. Cancer Discovery
- Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer
- (2021) Yusuke Inoue et al. eLife
- Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer
- (2021) Kasey R. Cargill et al. Cancer & Metabolism
- Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
- (2021) Joseph M. Chan et al. CANCER CELL
- Lung neuroendocrine neoplasms: recent progress and persistent challenges
- (2021) Natasha Rekhtman MODERN PATHOLOGY
- Non-genetic determinants of malignant clonal fitness at single-cell resolution
- (2021) Katie A. Fennell et al. NATURE
- Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium
- (2021) Jasmine Chen et al. ONCOGENE
- Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer
- (2021) Paloma Cejas et al. Nature Communications
- Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer
- (2021) Ming Chen et al. Nature Communications
- Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis
- (2021) Yujuan Jin et al. National Science Review
- YAP drives fate conversion and chemoresistance of small cell lung cancer
- (2021) Qingzhe Wu et al. Science Advances
- MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer
- (2021) Rebecca Caeser et al. iScience
- Transient Sox9 Expression Facilitates Progression to Castrate Resistant Prostate Cancer
- (2020) Mannan Nouri et al. CLINICAL CANCER RESEARCH
- New Approaches to SCLC Therapy: From the Laboratory to the Clinic
- (2020) John T. Poirier et al. Journal of Thoracic Oncology
- MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
- (2020) Arnaud Augert et al. CANCER CELL
- MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate
- (2020) Abbie S. Ireland et al. CANCER CELL
- Harnessing natural killer immunity in metastatic small cell lung cancer
- (2020) Sarah A. Best et al. Journal of Thoracic Oncology
- Lurbinectedin as second-line treatment for patients with small-cell lung cancer: a single-arm, open-label, phase 2 basket trial
- (2020) José Trigo et al. LANCET ONCOLOGY
- MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression
- (2020) Yuto Yasuda et al. Cell Death & Disease
- The rare YAP1 subtype of Small Cell Lung Cancer revisited in a biobank of 39 Circulating Tumour Cell Patient Derived eXplant models (CDX): A brief report
- (2020) Sarah M. Pearsall et al. Journal of Thoracic Oncology
- Neuroendocrine subtypes of small cell lung cancer differ in terms of immune microenvironment and checkpoint molecule distribution
- (2020) David Dora et al. Molecular Oncology
- The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis
- (2020) Xiaomeng Zhang et al. ONCOGENE
- Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer
- (2020) John R. Christin et al. Cell Reports
- MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity
- (2020) Eli Grunblatt et al. GENES & DEVELOPMENT
- Small Cell Lung Carcinoma Subtypes Defined by ASCL1, NEUROD1, POU2F3 and YAP1: Comprehensive Immunohistochemical and Histopathologic Characterization
- (2020) Marina K. Baine et al. Journal of Thoracic Oncology
- SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures
- (2020) Camille Tlemsani et al. Cell Reports
- FDA Approval Summary: Lurbinectedin for the Treatment of Metastatic Small Cell Lung Cancer
- (2020) Sonia Singh et al. CLINICAL CANCER RESEARCH
- Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer
- (2020) Fang Huang et al. JOURNAL OF CLINICAL INVESTIGATION
- YAP1 Expression in SCLC Defines a Distinct Subtype With T-cell–Inflamed Phenotype
- (2020) Taofeek K. Owonikoko et al. Journal of Thoracic Oncology
- The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters
- (2019) Arnold J. Levine et al. CANCER CELL
- Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer
- (2019) Triparna Sen et al. Cancer Discovery
- Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition
- (2019) Arnaud Augert et al. Science Signaling
- First-Line Nivolumab Plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer (CheckMate 568): Outcomes by Programmed Death Ligand 1 and Tumor Mutational Burden as Biomarkers
- (2019) Neal Ready et al. JOURNAL OF CLINICAL ONCOLOGY
- A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients
- (2019) Joseph Cursons et al. Cancer Immunology Research
- MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion
- (2019) Milind D. Chalishazar et al. CLINICAL CANCER RESEARCH
- DLL3: an emerging target in small cell lung cancer
- (2019) Dwight H. Owen et al. Journal of Hematology & Oncology
- An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
- (2019) Marian L. Burr et al. CANCER CELL
- Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small Cell Lung Cancer: Results From the Phase II TRINITY Study
- (2019) Daniel Morgensztern et al. CLINICAL CANCER RESEARCH
- Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch
- (2019) Youcef Ouadah et al. CELL
- Notch signaling in the mammalian respiratory system, specifically the trachea and lungs, in development, homeostasis, regeneration, and disease
- (2019) Hirofumi Kiyokawa et al. DEVELOPMENT GROWTH & DIFFERENTIATION
- The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis
- (2019) Matthew G. Oser et al. GENES & DEVELOPMENT
- Randomized Phase II Study of Paclitaxel plus Alisertib versus Paclitaxel plus Placebo as Second-Line Therapy for SCLC: Primary and Correlative Biomarker Analyses
- (2019) Taofeek K. Owonikoko et al. Journal of Thoracic Oncology
- Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial
- (2019) Luis Paz-Ares et al. LANCET
- The great escape: tumour cell plasticity in resistance to targeted therapy
- (2019) Soufiane Boumahdi et al. NATURE REVIEWS DRUG DISCOVERY
- MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
- (2019) Marcel A. Dammert et al. Nature Communications
- Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers
- (2019) David J. Wooten et al. PLoS Computational Biology
- CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
- (2019) Hua Zhang et al. CANCER CELL
- Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer
- (2018) Matthew D. Hellmann et al. CANCER CELL
- Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
- (2018) Fang Huang et al. Cell Metabolism
- POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer
- (2018) Yu-Han Huang et al. GENES & DEVELOPMENT
- Crosstalk between YAP/TAZ and Notch Signaling
- (2018) Antonio Totaro et al. TRENDS IN CELL BIOLOGY
- Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
- (2018) Benjamin J. Drapkin et al. Cancer Discovery
- Abstract 3709: Characterization, in vitro and in vivo efficacy studies of docetaxel trastuzumab stealth immunoliposome in human breast cancer models
- (2018) Anne Rodallec et al. CANCER RESEARCH
- Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
- (2018) Alexander Muir et al. Disease Models & Mechanisms
- A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte
- (2018) Lindsey W. Plasschaert et al. NATURE
- A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
- (2018) Daniel T. Montoro et al. NATURE
- First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer
- (2018) Leora Horn et al. NEW ENGLAND JOURNAL OF MEDICINE
- Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer
- (2018) Alex H. Wagner et al. Nature Communications
- Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition
- (2018) Deshui Jia et al. Cancer Discovery
- Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer
- (2018) Yumeng Wang et al. Cell Reports
- Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus
- (2017) Linde A. Miles et al. JOURNAL OF CLINICAL INVESTIGATION
- Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2 : CALGB 151111 (Alliance)
- (2017) Arnaud Augert et al. Journal of Thoracic Oncology
- Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study
- (2017) Charles M Rudin et al. LANCET ONCOLOGY
- Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer
- (2017) Jing Shan Lim et al. NATURE
- Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
- (2017) Matthew J. Hangauer et al. NATURE
- Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
- (2017) Vasanthi S. Viswanathan et al. NATURE
- Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer
- (2017) Karen McColl et al. Oncotarget
- Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies
- (2017) Robert J. Cardnell et al. Oncotarget
- Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer
- (2017) Fabian Doerr et al. Scientific Reports
- YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer
- (2016) Masafumi Horie et al. CANCER SCIENCE
- Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility
- (2016) Sarah K. Denny et al. CELL
- Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis
- (2016) Hiromi Shimojo et al. GENES & DEVELOPMENT
- CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer
- (2016) Kipp Weiskopf et al. JOURNAL OF CLINICAL INVESTIGATION
- Lung Cancer Subtypes Generate Unique Immune Responses
- (2016) Stephanie E. Busch et al. JOURNAL OF IMMUNOLOGY
- Barasertib (AZD1152), a Small Molecule Aurora B Inhibitor, Inhibits the Growth of SCLC Cell Lines In Vitro and In Vivo
- (2016) B. A. Helfrich et al. MOLECULAR CANCER THERAPEUTICS
- The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
- (2016) András Kotschy et al. NATURE
- Mutational signatures associated with tobacco smoking in human cancer
- (2016) L. B. Alexandrov et al. SCIENCE
- Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network
- (2016) Shuguo Sun et al. TRENDS IN CELL BIOLOGY
- Vasculogenic mimicry in small cell lung cancer
- (2016) Stuart C. Williamson et al. Nature Communications
- NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer
- (2016) Nan Wu et al. Oncotarget
- Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients
- (2016) Ekaterina A. Semenova et al. Cell Reports
- ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs
- (2016) Mark D. Borromeo et al. Cell Reports
- Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer
- (2016) Narsis Attar et al. Cold Spring Harbor Perspectives in Medicine
- Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer
- (2015) Kosuke Fujino et al. AMERICAN JOURNAL OF PATHOLOGY
- A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC
- (2015) Helai P. Mohammad et al. CANCER CELL
- Insm1 controls the differentiation of pulmonary neuroendocrine cells by repressing Hes1
- (2015) Shiqi Jia et al. DEVELOPMENTAL BIOLOGY
- Paracrine signaling between tumor subclones of mouse SCLC: a critical role of ETS transcription factor Pea3 in facilitating metastasis
- (2015) Min-chul Kwon et al. GENES & DEVELOPMENT
- Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin
- (2015) Matthew G Oser et al. LANCET ONCOLOGY
- Comprehensive genomic profiles of small cell lung cancer
- (2015) Julie George et al. NATURE
- DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2
- (2015) J T Poirier et al. ONCOGENE
- Neoantigens in cancer immunotherapy
- (2015) T. N. Schumacher et al. SCIENCE
- A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo
- (2015) Laura R. Saunders et al. Science Translational Medicine
- RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
- (2015) Matthew J. Niederst et al. Nature Communications
- Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor
- (2014) Camilla L. Christensen et al. CANCER CELL
- Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing
- (2014) David G. McFadden et al. CELL
- Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells
- (2014) Sudha Mannava et al. CELL CYCLE
- Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells
- (2014) Ivo J Huijbers et al. EMBO Molecular Medicine
- ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers
- (2014) A. Augustyn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective Tropism of Seneca Valley Virus for Variant Subtype Small Cell Lung Cancer
- (2013) J. T. Poirier et al. JNCI-Journal of the National Cancer Institute
- Signatures of mutational processes in human cancer
- (2013) Ludmil B. Alexandrov et al. NATURE
- NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM
- (2013) J. K. Osborne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MAX Inactivation in Small Cell Lung Cancer Disrupts MYC-SWI/SNF Programs and Is Synthetic Lethal with BRG1
- (2013) O. A. Romero et al. Cancer Discovery
- PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
- (2013) Teruyuki Sato et al. Scientific Reports
- An Integrated Genomic Approach to Identify Predictive Biomarkers of Response to the Aurora Kinase Inhibitor PF-03814735
- (2012) K. E. Hook et al. MOLECULAR CANCER THERAPEUTICS
- Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
- (2012) Charles M Rudin et al. NATURE GENETICS
- Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
- (2012) Martin Peifer et al. NATURE GENETICS
- A framework for identification of actionable cancer genome dependencies in small cell lung cancer
- (2012) M. L. Sos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer
- (2011) Joaquim Calbo et al. CANCER CELL
- Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung
- (2011) Kate D. Sutherland et al. CANCER CELL
- Characterization of the cell of origin for small cell lung cancer
- (2011) Kwon-Sik Park et al. CELL CYCLE
- Nuclear factor I/B is an oncogene in small cell lung cancer
- (2011) A. L. Dooley et al. GENES & DEVELOPMENT
- Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation
- (2010) Qihuang Jin et al. EMBO JOURNAL
- Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate
- (2010) M. Morimoto et al. JOURNAL OF CELL SCIENCE
- Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development
- (2009) Branden R. Nelson et al. DEVELOPMENTAL DYNAMICS
- A small-cell lung cancer genome with complex signatures of tobacco exposure
- (2009) Erin D. Pleasance et al. NATURE
- Targeted Disruption of NeuroD, a Proneural Basic Helix-Loop-Helix Factor, Impairs Distal Lung Formation and Neuroendocrine Morphology in the Neonatal Lung
- (2008) Enid R. Neptune et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now