Metabolic programs tailor T cell immunity in viral infection, cancer, and aging

Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8+ T Cells in Elderly Humans

(2022) Francesco Nicoli et al.   JOURNAL OF IMMUNOLOGY

Expanding the link between circadian rhythms and redox metabolism of epigenetic control

(2021) Tomoki Sato et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

(2021) Nicole E. Scharping et al.   NATURE IMMUNOLOGY

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

(2021) Xingzhe Ma et al.   Cell Metabolism

Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients

(2021) Diwakar Davar et al.   SCIENCE

Microbial Regulation of Host Physiology by Short-chain Fatty Acids

(2021) Bart van der Hee et al.   TRENDS IN MICROBIOLOGY

Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma

(2021) Man Hsin Hung et al.   Nature Communications

Metabolic programs define dysfunctional immune responses in severe COVID-19 patients

(2021) Elizabeth A. Thompson et al.   Cell Reports

Epigenetic Landscapes of Single-Cell Chromatin Accessibility and Transcriptomic Immune Profiles of T Cells in COVID-19 Patients

(2021) Shun Li et al.   Frontiers in Immunology

Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

(2021) Yao He et al.   Cell Metabolism

Kdm6b Regulates the Generation of Effector CD8+ T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes

(2021) Tianhao Xu et al.   JOURNAL OF IMMUNOLOGY

An aged immune system drives senescence and ageing of solid organs

(2021) Matthew J. Yousefzadeh et al.   NATURE

Hallmarks of T cell aging

(2021) Maria Mittelbrunn et al.   NATURE IMMUNOLOGY

Single-cell multi-omics analysis of the immune response in COVID-19

(2021) Emily Stephenson et al.   NATURE MEDICINE

KDM6B-dependent chromatin remodeling underpins effective virus-specific CD8+ T cell differentiation

(2021) Jasmine Li et al.   Cell Reports

Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

(2021) Silvia Vaena et al.   Cell Reports

Role of Epigenetic Regulation in Plasticity of Tumor Immune Microenvironment

(2021) Yunkai Yang et al.   Frontiers in Immunology

O-GlcNAcylation and O-GlcNAc Cycling Regulate Gene Transcription: Emerging Roles in Cancer

(2021) Matthew P. Parker et al.   Cancers

Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

(2021) Sarah S. Gabriel et al.   IMMUNITY

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

(2021) Shihao Xu et al.   IMMUNITY

Metabolic Defects of Peripheral T Cells in COVID-19 Patients

(2021) Xiaoju Liu et al.   JOURNAL OF IMMUNOLOGY

Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans

(2021) Kathleen B. Yates et al.   NATURE IMMUNOLOGY

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

(2021) Mohamed S. Abdel-Hakeem et al.   NATURE IMMUNOLOGY

Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity

(2021) Yugang Guo et al.   NATURE IMMUNOLOGY

Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

(2021) Pierre Tonnerre et al.   NATURE IMMUNOLOGY

Critical role of the CD44lowCD62Llow CD8+ T cell subset in restoring antitumor immunity in aged mice

(2021) Yuka Nakajima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversing Post-Infectious Epigenetic-Mediated Immune Suppression

(2021) Abhimanyu et al.   Frontiers in Immunology

Cancer as a disease of old age: changing mutational and microenvironmental landscapes

(2020) Ezio Laconi et al.   BRITISH JOURNAL OF CANCER

Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection

(2020) Valeria Barili et al.   Nature Communications

The microbiota programs DNA methylation to control intestinal homeostasis and inflammation

(2020) Ihab Ansari et al.   Nature Microbiology

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Bystanders or real players: virtual memory T cells keep chronic infections in check

(2020) Kylie M. Quinn et al.   Cellular & Molecular Immunology

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

(2020) Meijuan Zheng et al.   Cellular & Molecular Immunology

Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients

(2020) Hong-Yi Zheng et al.   Cellular & Molecular Immunology

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

(2020) Tao Zuo et al.   GASTROENTEROLOGY

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

(2020) Jean-Christophe Beltra et al.   IMMUNITY

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

(2020) Irani Thevarajan et al.   NATURE MEDICINE

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

(2020) Clélia Coutzac et al.   Nature Communications

Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis

(2020) Amy I. Yu et al.   Cell Reports

Circadian Regulation of Immunity Through Epigenetic Mechanisms

(2020) Ricardo Orozco-Solis et al.   Frontiers in Cellular and Infection Microbiology

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

FOXO1 deficiency impairs proteostasis in aged T cells

(2020) Jun Jin et al.   Science Advances

The Impact of the Microbiome on Immunity to Vaccination in Humans

(2020) Sanne E. de Jong et al.   Cell Host & Microbe

Alterations of the Gut Microbiota in Patients With Coronavirus Disease 2019 or H1N1 Influenza

(2020) Silan Gu et al.   CLINICAL INFECTIOUS DISEASES

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

(2020) Alessio Mazzoni et al.   JOURNAL OF CLINICAL INVESTIGATION

Microbiota-derived metabolite promotes HDAC3 activity in the gut

(2020) Shu-en Wu et al.   NATURE

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

(2020) Robert Lorenz Chua et al.   NATURE BIOTECHNOLOGY

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

(2020) Santosha A. Vardhana et al.   NATURE IMMUNOLOGY

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

(2020) Divij Mathew et al.   SCIENCE

Comprehensive mapping of immune perturbations associated with severe COVID-19

(2020) Leticia Kuri-Cervantes et al.   Science Immunology

Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

(2020) Yi-Ru Yu et al.   NATURE IMMUNOLOGY

Circulation of gut-preactivated naïve CD8+T cells enhances antitumor immunity in B cell-defective mice

(2020) Maryam Akrami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Metabolic Changes and Immune Profiles in Patients With COVID-19

(2020) Bing He et al.   Frontiers in Immunology

Circadian Host-Microbiome Interactions in Immunity

(2020) Thomas D. Butler et al.   Frontiers in Immunology

Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways

(2020) Yi-Na Liu et al.   Frontiers in Immunology

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

(2020) Yapeng Su et al.   CELL

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

(2020) Denis A. Mogilenko et al.   IMMUNITY

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

(2020) Erez N. Baruch et al.   SCIENCE

Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses

(2020) Ghada Alsaleh et al.   eLife

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

(2019) Xiaoyun Li et al.   Nature Reviews Clinical Oncology

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

(2019) Takeshi Tanoue et al.   NATURE

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Similar but different: Virtual memory CD 8 T cells as a memory‐like cell population

(2019) Tabinda Hussain et al.   IMMUNOLOGY AND CELL BIOLOGY

Acetate Promotes T Cell Effector Function during Glucose Restriction

(2019) Jing Qiu et al.   Cell Reports

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells

(2019) Annabell Bachem et al.   IMMUNITY

The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction

(2019) Nicholas Collins et al.   CELL

The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways

(2019) Chloé C. Nobis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

(2019) Arsun Bektas et al.   Aging-US

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

Author Correction: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

Metabolic Control of Epigenetics and Its Role in CD8+ T Cell Differentiation and Function

(2019) Cansu Yerinde et al.   Frontiers in Immunology

Mitochondrial mass governs the extent of human T cell senescence

(2019) Lauren A. Callender et al.   AGING CELL

Dietary Fiber Confers Protection against Flu by Shaping Ly6c − Patrolling Monocyte Hematopoiesis and CD8 + T Cell Metabolism

(2018) Aurélien Trompette et al.   IMMUNITY

Asynchronous rhythms of circulating conjugated and unconjugated bile acids in the modulation of human metabolism

(2018) Amani Al-Khaifi et al.   JOURNAL OF INTERNAL MEDICINE

Epigenetics of T cell aging

(2018) Jörg J. Goronzy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

Metabolic Control of CD8 + T Cell Fate Decisions and Antitumor Immunity

(2018) Lianjun Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Age-Related Decline in Primary CD8 + T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8 + T Cells

(2018) Kylie M. Quinn et al.   Cell Reports

Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate

(2018) Maik Luu et al.   Scientific Reports

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

(2018) Minkyung Song et al.   NATURE

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice

(2018) Noga Ron-Harel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8 + T Cell Terminal Differentiation and Loss of Multipotency

(2017) Simon M. Gray et al.   IMMUNITY

Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses

(2017) David Druzd et al.   IMMUNITY

Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity

(2017) Anthony T. Phan et al.   IMMUNITY

Glutathione Primes T Cell Metabolism for Inflammation

(2017) Tak W. Mak et al.   IMMUNITY

Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

(2017) Haiyan Tan et al.   IMMUNITY

The chromatin accessibility signature of human immune aging stems from CD8+T cells

(2017) Duygu Ucar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis

(2017) Hossam A. Abdelsamed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Loss of TET2 Promotes CD8+T Cell Memory Differentiation

(2017) Shannon A. Carty et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory

(2017) Christopher D. Scharer et al.   JOURNAL OF IMMUNOLOGY

Effector CD8 T cells dedifferentiate into long-lived memory cells

(2017) Ben Youngblood et al.   NATURE

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B

(2017) Paola Fisicaro et al.   NATURE MEDICINE

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation

(2017) Nazanin Navabi et al.   Cell Reports

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

(2016) Stefano Di Biase et al.   CANCER CELL

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

(2016) Meital Gury-BenAri et al.   CELL

Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations

(2016) Christoph A. Thaiss et al.   CELL

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

Constitutive Glycolytic Metabolism Supports CD8 + T Cell Effector Memory Differentiation during Viral Infection

(2016) Anthony T. Phan et al.   IMMUNITY

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

Dynamic Changes in Chromatin Accessibility Occur in CD8 + T Cells Responding to Viral Infection

(2016) James P. Scott-Browne et al.   IMMUNITY

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

Glycolysis determines dichotomous regulation of T cell subsets in hypoxia

(2016) Yang Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

(2016) Petros A. Tyrakis et al.   NATURE

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

(2016) Mahima Swamy et al.   NATURE IMMUNOLOGY

Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes

(2016) Nicholas P. Semenkovich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+T-cell fate decisions following activation

(2016) Brian H. Ladle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

(2016) Anna Schurich et al.   Cell Reports

Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection

(2016) Wenjuan Tu et al.   Frontiers in Microbiology

Metabolic communication in tumors: a new layer of immunoregulation for immune evasion

(2016) Ping-Chih Ho et al.   Journal for ImmunoTherapy of Cancer

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism

(2015) Vanessa Leone et al.   Cell Host & Microbe

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Metabolic Signaling to Chromatin

(2015) Shelley L. Berger et al.   Cold Spring Harbor Perspectives in Biology

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8+ T cells

(2015) Valérie Martinet et al.   Nature Communications

Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes

(2015) Liina Tserel et al.   Scientific Reports

The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function

(2015) Saskia Hemmers et al.   Cell Reports

Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis

(2014) Christoph A. Thaiss et al.   CELL

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection

(2014) Matthew M. Staron et al.   IMMUNITY

Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8+ T Cell Differentiation

(2014) Brendan E. Russ et al.   IMMUNITY

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

(2014) Makoto Kurachi et al.   NATURE IMMUNOLOGY

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Two Separate Defects Affecting True Naive or Virtual Memory T Cell Precursors Combine To Reduce Naive T Cell Responses with Aging

(2013) K. R. Renkema et al.   JOURNAL OF IMMUNOLOGY

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

(2013) Clifford S Guy et al.   NATURE IMMUNOLOGY

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

Circadian acetylome reveals regulation of mitochondrial metabolic pathways

(2013) Selma Masri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian clock regulates the host response to Salmonella

(2013) M. M. Bellet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

(2013) N. Iida et al.   SCIENCE

Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6Chi Inflammatory Monocytes

(2013) K. D. Nguyen et al.   SCIENCE

Activation of the Transcriptional Function of the NF- B Protein c-Rel by O-GlcNAc Glycosylation

(2013) P. Ramakrishnan et al.   Science Signaling

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic pathways in T cell fate and function

(2012) Valerie A. Gerriets et al.   TRENDS IN IMMUNOLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Circadian Variation of the Response of T Cells to Antigen

(2011) E. E. Fortier et al.   JOURNAL OF IMMUNOLOGY

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Genome-wide Analysis of Histone Methylation Reveals Chromatin State-Based Regulation of Gene Transcription and Function of Memory CD8+ T Cells

(2009) Yasuto Araki et al.   IMMUNITY

LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response

(2008) Steven J. Bensinger et al.   CELL

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY