Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling

(2020) Yaoyao Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association of Short-Chain Fatty Acids in the Gut Microbiome With Clinical Response to Treatment With Nivolumab or Pembrolizumab in Patients With Solid Cancer Tumors

(2020) Motoo Nomura et al.   JAMA Network Open

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

(2019) Takeshi Tanoue et al.   NATURE

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells

(2019) Annabell Bachem et al.   IMMUNITY

Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+T cells

(2018) Kyla D. Omilusik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate

(2018) Maik Luu et al.   Scientific Reports

Anticancer effects of the microbiome and its products

(2017) Laurence Zitvogel et al.   NATURE REVIEWS MICROBIOLOGY

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

(2016) Gerard E. Kaiko et al.   CELL

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography–tandem mass spectrometry

(2015) Jun Han et al.   ANALYTICA CHIMICA ACTA

Revisit dietary fiber on colorectal cancer: butyrate and its role on prevention and treatment

(2015) J. C. Encarnação et al.   CANCER AND METASTASIS REVIEWS

Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota

(2015) Xiaohuan Guo et al.   IMMUNITY

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

T-cell-based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition

(2015) R. Houot et al.   Cancer Immunology Research

New insights into IL-12-mediated tumor suppression

(2014) S Tugues et al.   CELL DEATH AND DIFFERENTIATION

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Id2 Influences Differentiation of Killer Cell Lectin-like Receptor G1hi Short-Lived CD8+ Effector T Cells

(2013) J. Knell et al.   JOURNAL OF IMMUNOLOGY

Id2-Mediated Inhibition of E2A Represses Memory CD8+ T Cell Differentiation

(2013) F. Masson et al.   JOURNAL OF IMMUNOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Stool Microbiome and Metabolome Differences between Colorectal Cancer Patients and Healthy Adults

(2013) Tiffany L. Weir et al.   PLoS One

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

(2013) N. Iida et al.   SCIENCE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

(2013) S. Viaud et al.   SCIENCE

Id proteins synchronize stemness and anchorage to the niche of neural stem cells

(2012) Francesco Niola et al.   NATURE CELL BIOLOGY

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

(2011) Tingting Wang et al.   ISME Journal

The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets

(2011) Cliff Y Yang et al.   NATURE IMMUNOLOGY

A tutorial on pilot studies: the what, why and how

(2010) Lehana Thabane et al.   BMC Medical Research Methodology

The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells

(2009) E. L. Rawlins et al.   DEVELOPMENT