Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

(2016) Anna Schurich et al.   Cell Reports

Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases

(2015) Niki Chondrogianni et al.   AGEING RESEARCH REVIEWS

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Immune-Metabolic Basis of Effector Memory CD4+T Cell Function under Hypoxic Conditions

(2015) Sarah Dimeloe et al.   JOURNAL OF IMMUNOLOGY

Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection

(2015) Jonathan H Chen et al.   NATURE MEDICINE

EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection

(2015)   JOURNAL OF HEPATOLOGY

Autophagy and the immune function in aging

(2014) Ana Maria Cuervo et al.   CURRENT OPINION IN IMMUNOLOGY

Mitochondrial Metabolism in T Cell Activation and Senescence: A Mini-Review

(2014) Noga Ron-Harel et al.   GERONTOLOGY

Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation

(2014) Bertram Bengsch et al.   JOURNAL OF HEPATOLOGY

Control of mitochondrial integrity in ageing and disease

(2014) R. Szklarczyk et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

HSP70 mediates degradation of the p65 subunit of nuclear factor  B to inhibit inflammatory signaling

(2014) T. Tanaka et al.   Science Signaling

T cell antigen receptor activation and actin cytoskeleton remodeling

(2013) Sudha Kumari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Role of regulatory T cells during virus infection

(2013) Tamara Veiga-Parga et al.   IMMUNOLOGICAL REVIEWS

WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013

(2013) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

Combined Blockade of Programmed Death-1 and Activation of CD137 Increase Responses of Human Liver T Cells Against HBV, But Not HCV

(2012) Paola Fisicaro et al.   GASTROENTEROLOGY

Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

(2012) Travis A. Doering et al.   IMMUNITY

Inhibitory Receptors on Lymphocytes: Insights from Infections

(2012) P. M. Odorizzi et al.   JOURNAL OF IMMUNOLOGY

A travel guide to Cytoscape plugins

(2012) Rintaro Saito et al.   NATURE METHODS

DNA damage checkpoints in stem cells, ageing and cancer

(2012) Tobias Sperka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Upregulation of the Tim-3/Galectin-9 Pathway of T Cell Exhaustion in Chronic Hepatitis B Virus Infection

(2012) Gaia Nebbia et al.   PLoS One

Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection

(2011) Antonio Bertoletti et al.   GUT

Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection

(2011) Anna Schurich et al.   HEPATOLOGY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Aging and Immune Function: Molecular Mechanisms to Interventions

(2010) Subramaniam Ponnappan et al.   ANTIOXIDANTS & REDOX SIGNALING

Impaired quality control of mitochondria: Aging from a new perspective

(2010) Tobias A. Weber et al.   EXPERIMENTAL GERONTOLOGY

The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function

(2010) Bijan Raziorrouh et al.   HEPATOLOGY

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

(2010) Edward J. Gane et al.   LIVER INTERNATIONAL

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

(2010) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Regulatory T cells and viral liver disease

(2009) Nadia Alatrakchi et al.   JOURNAL OF VIRAL HEPATITIS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

The dual immunoregulatory roles of stress proteins

(2008) Alan Graham Pockley et al.   TRENDS IN BIOCHEMICAL SCIENCES

The immune system in extreme longevity

(2007) P. Sansoni et al.   EXPERIMENTAL GERONTOLOGY