Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

(2020) Julian Braun et al.   NATURE

A human circulating immune cell landscape in aging and COVID-19

(2020) Yingfeng Zheng et al.   Protein & Cell

Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration

(2019) Nikolas Giannakis et al.   NATURE IMMUNOLOGY

CD8+ T cells induce cachexia during chronic viral infection

(2019) Hatoon Baazim et al.   NATURE IMMUNOLOGY

The role of ceramide in regulating endoplasmic reticulum function

(2019) Iris D. Zelnik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity

(2019) Philipp Hammerschmidt et al.   CELL

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

Hallmarks of senescence and aging

(2019) Slavica Dodig et al.   Biochemia Medica

Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

(2019) Paramita Chakraborty et al.   Cell Reports

Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress

(2019) Natalia Oleinik et al.   Science Advances

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

(2019) Arsun Bektas et al.   Aging-US

CD38-NAD + Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

(2018) Shilpak Chatterjee et al.   Cell Metabolism

Signal transduction changes in CD4 + and CD8 + T cell subpopulations with aging

(2018) Aurélie Le Page et al.   EXPERIMENTAL GERONTOLOGY

Balance between senescence and apoptosis is regulated by telomere damage–induced association between p16 and caspase-3

(2018) Shanmugam Panneer Selvam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of sphingolipids in senescence: implication in aging and age-related diseases

(2018) Magali Trayssac et al.   JOURNAL OF CLINICAL INVESTIGATION

Age-Related Decline in Primary CD8 + T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8 + T Cells

(2018) Kylie M. Quinn et al.   Cell Reports

The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process

(2018) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure

(2018) Bryce A. Mendelsohn et al.   PLOS BIOLOGY

CD8+, but not CD4+ effector/memory T cells, express the CD44highCD45RBhigh phenotype with aging, which displays reduced expression levels of P2X7 receptor and ATP-induced cellular responses

(2018) Amine Mellouk et al.   FASEB JOURNAL

Immunoregulatory role of ASM in allergic asthma

(2018) Nina Sopel et al.   IMMUNOLOGY

Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA–dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis

(2018) Rose Nganga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

(2018) Paras S. Minhas et al.   NATURE IMMUNOLOGY

Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming

(2018) Luca Simula et al.   Cell Reports

Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Haidong Wang et al.   LANCET

Metabolic adventures in aging research

(2017) Holly M. Brown-Borg et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aging increases cell-to-cell transcriptional variability upon immune stimulation

(2017) Celia Pilar Martinez-Jimenez et al.   SCIENCE

TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis

(2017) Salih Gencer et al.   Science Signaling

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

(2017) Anil Rana et al.   Nature Communications

Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis

(2017) Matthew J. Scheffel et al.   Scientific Reports

TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis

(2017) Salih Gencer et al.   Science Signaling

 -Lipoic acid promotes  -tubulin hyperacetylation and blocks the turnover of mitochondria through mitophagy

(2016) M. W. Stoner et al.   BIOCHEMICAL JOURNAL

Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML

(2016) Mohammed Dany et al.   BLOOD

Fine-Tuning of CD8 + T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus

(2016) Devin P. Champagne et al.   IMMUNITY

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

(2016) Amanpreet Kaur et al.   NATURE

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

(2016) Vesna Pulko et al.   NATURE IMMUNOLOGY

Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function

(2016) Jae Kyo Yi et al.   Oncotarget

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

(2016) Ivan Montoliu et al.   Aging-US

Altering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle via KCa1.1 upregulation

(2015) Shinkyu Choi et al.   AGING CELL

Ceramide induced mitophagy and tumor suppression

(2015) Mohammed Dany et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Out-of-Sequence Signal 3 Paralyzes Primary CD4+ T-Cell-Dependent Immunity

(2015) Gail D. Sckisel et al.   IMMUNITY

Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction

(2015) Claire A. Chougnet et al.   JOURNAL OF IMMUNOLOGY

HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation

(2015) Victoria A. Blaho et al.   NATURE

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

(2015) Shanmugam Panneer Selvam et al.   Science Signaling

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

(2015) Shanmugam Panneer Selvam et al.   Science Signaling

Reducing CD73 Expression by IL1 -Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors

(2014) S. Chatterjee et al.   CANCER RESEARCH

Mitochondrial Metabolism in T Cell Activation and Senescence: A Mini-Review

(2014) Noga Ron-Harel et al.   GERONTOLOGY

Futility Sustains Memory T Cells

(2014) Samuel E. Weinberg et al.   IMMUNITY

Signaling through the Adaptor Molecule MyD88 in CD4+ T Cells Is Required to Overcome Suppression by Regulatory T Cells

(2014) Dominik Schenten et al.   IMMUNITY

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

Autophagy in T-cell development, activation and differentiation

(2014) Alisha W Bronietzki et al.   IMMUNOLOGY AND CELL BIOLOGY

Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans

(2014) Roy G. Cutler et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan

(2013) Jun Liu et al.   AGING CELL

Ceramide synthases as potential targets for therapeutic intervention in human diseases

(2013) Joo-Won Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse Models

(2013) Irina Petrache et al.   PLoS One

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity

(2011) Christine C. Yang et al.   AGING CELL

Selective T Cell Expansion during Aging of CD8 Memory Repertoires to Influenza Revealed by Modeling

(2011) Y. N. Naumov et al.   JOURNAL OF IMMUNOLOGY

Potentiation of Th17 cytokines in aging process contributes to the development of colitis

(2010) Xinshou Ouyang et al.   CELLULAR IMMUNOLOGY

Naive CD4 T cells from aged mice show enhanced death upon primary activation

(2009) Hamid Mattoo et al.   INTERNATIONAL IMMUNOLOGY

Elevated Mitochondrial Reactive Oxygen Species Generation Affects the Immune Response via Hypoxia-Inducible Factor-1  in Long-Lived Mclk1+/- Mouse Mutants

(2009) D. Wang et al.   JOURNAL OF IMMUNOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE