Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection

Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation

(2016) Laurie D. Snyder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: A systematic review

(2016) Marlies Weltevrede et al.   EXPERIMENTAL GERONTOLOGY

Effect of age and latent CMV infection on CD8+ CD56+ T cells (NKT-like) frequency and functionality

(2016) Fakhri Hassouneh et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The silent war of CMV in aging and HIV infection

(2016) Rita B. Effros   MECHANISMS OF AGEING AND DEVELOPMENT

Molecular characterization of HCMV-specific immune responses: Parallels between CD8+T cells, CD4+T cells, and NK cells

(2015) Felipe A. Vieira Braga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

5th International Workshop on CMV and Immunosenescence - A shadow of cytomegalovirus infection on immunological memory

(2015) Ramon Arens et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Evidence for eomesodermin-expressing innate-like CD8+KIR/NKG2A+T cells in human adults and cord blood samples

(2015) Florence Jacomet et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Naive T Cell Maintenance and Function in Human Aging

(2015) Jörg J. Goronzy et al.   JOURNAL OF IMMUNOLOGY

Pathogen-Specific T Cell Polyfunctionality Is a Correlate of T Cell Efficacy and Immune Protection

(2015) Anders Boyd et al.   PLoS One

Resident memory T cells in human health and disease

(2015) R. A. Clark   Science Translational Medicine

Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes

(2015) Liina Tserel et al.   Scientific Reports

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

(2015) Yasumichi Arai et al.   EBioMedicine

With a little help from my old T cell: Memory follicular T helper cells driving autoimmunity?

(2014) Thomas H. Winkler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

New advances in CMV and immunosenescence

(2014) Paolo Sansoni et al.   EXPERIMENTAL GERONTOLOGY

CD4 T cell defects in the aged: Causes, consequences and strategies to circumvent

(2014) Wenliang Zhang et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial Metabolism in T Cell Activation and Senescence: A Mini-Review

(2014) Noga Ron-Harel et al.   GERONTOLOGY

Immunosenescence and vaccine failure in the elderly: Strategies for improving response

(2014) Diana Boraschi et al.   IMMUNOLOGY LETTERS

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

(2014) O. V. Britanova et al.   JOURNAL OF IMMUNOLOGY

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

(2014) A. M. Wertheimer et al.   JOURNAL OF IMMUNOLOGY

Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories

(2014) Janko Nikolich-Žugich   JOURNAL OF IMMUNOLOGY

Heterogeneity of CD4+ and CD8+ T-cell Responses to Cytomegalovirus in HIV-Infected and HIV-Uninfected Men Who Have Sex With Men

(2014) Huifen Li et al.   JOURNAL OF INFECTIOUS DISEASES

Signatures of malaria vaccine efficacy in ageing murine immune memory

(2014) J. M. Haussig et al.   PARASITE IMMUNOLOGY

CMV Latent Infection Improves CD8+ T Response to SEB Due to Expansion of Polyfunctional CD57+ Cells in Young Individuals

(2014) Alejandra Pera et al.   PLoS One

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

Controlling Cytomegalovirus: Helping the Immune System Take the Lead

(2014) Patrick Hanley et al.   Viruses-Basel

Age-related differences in polyfunctional T cell responses

(2014) Puja Van Epps et al.   Immunity & Ageing

The effect of aging on the frequency, phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells: comparison of aged and young subjects

(2014) Maohua Zhou et al.   Immunity & Ageing

Aging is associated with increased regulatory T-cell function

(2013) Sanjay K. Garg et al.   AGING CELL

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection

(2013) Mark R. Schleiss   Clinical & Developmental Immunology

T Cell Replicative Senescence in Human Aging

(2013) Jennifer P. Chou et al.   CURRENT PHARMACEUTICAL DESIGN

The who's who of T-cell differentiation: Human memory T-cell subsets

(2013) Yolanda D. Mahnke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Increased Th17 differentiation in aged mice is significantly associated with high IL-1β level and low IL-2 expression

(2013) Mi-Ae Lim et al.   EXPERIMENTAL GERONTOLOGY

Two Separate Defects Affecting True Naive or Virtual Memory T Cell Precursors Combine To Reduce Naive T Cell Responses with Aging

(2013) K. R. Renkema et al.   JOURNAL OF IMMUNOLOGY

Intensity of the Humoral Response to Cytomegalovirus Is Associated with the Phenotypic and Functional Status of the Immune System

(2013) R. Alonso Arias et al.   JOURNAL OF VIROLOGY

Nutrition, diet and immunosenescence

(2013) Mònica Maijó et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

How to Define Biomarkers of Human T Cell Aging and Immunocompetence?

(2013) Dietmar Herndler-Brandstetter et al.   Frontiers in Immunology

The Impact of Aging on Regulatory T-Cells

(2013) Johannes Fessler et al.   Frontiers in Immunology

When aging reaches CD4+ T-cells: phenotypic and functional changes

(2013) Marco Antonio Moro-García   Frontiers in Immunology

T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis

(2013) Guobing Chen et al.   Frontiers in Immunology

Immunosenescence and Novel Vaccination Strategies for the Elderly

(2013) Michael G. Dorrington et al.   Frontiers in Immunology

Immunosenescence is associated with altered gene expression and epigenetic regulation in primary and secondary immune organs

(2013) Corinne Sidler et al.   Frontiers in Genetics

Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8+ T cells sensitizing them to apoptotic cell death

(2012) Stefan Brunner et al.   AGING CELL

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

(2012) Scott N. Mueller et al.   Annual Review of Immunology

Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

(2012) Taheri Sathaliyawala et al.   IMMUNITY

Diverse immune evasion strategies by human cytomegalovirus

(2012) Vanessa Noriega et al.   IMMUNOLOGIC RESEARCH

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Postnatal development- and age-related changes in DNA-methylation patterns in the human genome

(2012) Paraskevi Salpea et al.   NUCLEIC ACIDS RESEARCH

Distinct DNA methylomes of newborns and centenarians

(2012) H. Heyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

(2012) Rafael Solana et al.   SEMINARS IN IMMUNOLOGY

Memory T cell inflation: understanding cause and effect

(2012) Geraldine A. O’Hara et al.   TRENDS IN IMMUNOLOGY

Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination

(2012) Evelyna Derhovanessian et al.   VACCINE

Early Priming Minimizes the Age-Related Immune Compromise of CD8+ T Cell Diversity and Function

(2012) Sophie A. Valkenburg et al.   PLoS Pathogens

Immune Senescence: Relative Contributions of Age and Cytomegalovirus Infection

(2012) Andrea Mekker et al.   PLoS Pathogens

CMV and Immunosenescence: from basics to clinics

(2012) Rafael Solana et al.   Immunity & Ageing

Age-associated alteration in naive and memory Th17 cell response in humans

(2011) Jin Soo Lee et al.   CLINICAL IMMUNOLOGY

The contribution of epigenetic memory to immunologic memory

(2011) Valerie P Zediak et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Serum antibody response to the gH/gL/pUL128–131 five-protein complex of human cytomegalovirus (HCMV) in primary and reactivated HCMV infections

(2011) Emilia Genini et al.   JOURNAL OF CLINICAL VIROLOGY

Increased Numbers of Preexisting Memory CD8 T Cells and Decreased T-bet Expression Can Restrain Terminal Differentiation of Secondary Effector and Memory CD8 T Cells

(2011) Nikhil S. Joshi et al.   JOURNAL OF IMMUNOLOGY

The impact of aging on memory T cell phenotype and function in the human bone marrow

(2011) Dietmar Herndler-Brandstetter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

(2011) Jonathan Sprent et al.   NATURE IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

MF59 Adjuvant Enhances Diversity and Affinity of Antibody-Mediated Immune Response to Pandemic Influenza Vaccines

(2011) S. Khurana et al.   Science Translational Medicine

Age-related decrease of miRNA-92a levels in human CD8+ T-cells correlates with a reduction of naïve T lymphocytes

(2011) Michiyo Ohyashiki et al.   Immunity & Ageing

Aging and Immune Function: Molecular Mechanisms to Interventions

(2010) Subramaniam Ponnappan et al.   ANTIOXIDANTS & REDOX SIGNALING

Immune memory and aging: an infinite or finite resource?

(2010) Janko Nikolich-Žugich et al.   CURRENT OPINION IN IMMUNOLOGY

How chronic viral infections impact on antigen-specific T-cell responses

(2010) Helge Frebel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epigenetics and gene expression

(2010) E R Gibney et al.   HEREDITY

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

Transcription factor regulation of CD8+ T-cell memory and exhaustion

(2010) Jill M. Angelosanto et al.   IMMUNOLOGICAL REVIEWS

Hallmark Features of Immunosenescence Are Absent in Familial Longevity

(2010) E. Derhovanessian et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

(2010) A. Banerjee et al.   JOURNAL OF IMMUNOLOGY

The Role of Nutrition in Immunity in the Aged

(2010) Bruno M. Lesourd et al.   NUTRITION REVIEWS

Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection

(2010) Michael J. Cannon et al.   REVIEWS IN MEDICAL VIROLOGY

Epigenetic regulation of the immune system in health and disease

(2010) J. L. Fernández-Morera et al.   TISSUE ANTIGENS

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

The role of adjuvants in vaccines for seasonal and pandemic influenza

(2010) Lorena E. Brown   VACCINE

Human cytomegalovirus immunity and immune evasion

(2010) Sarah E. Jackson et al.   VIRUS RESEARCH

Role of chromatin states in transcriptional memory

(2009) Sharmistha Kundu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals

(2009) S. Chidrawar et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Role of Epigenetics in Aging and Autoimmunity

(2009) Annabelle Grolleau-Julius et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Future directions in genetic for autoimmune diseases

(2009) Pietro Invernizzi   JOURNAL OF AUTOIMMUNITY

The genetics and epigenetics of autoimmune diseases

(2009) Anura Hewagama et al.   JOURNAL OF AUTOIMMUNITY

Congenital cytomegalovirus (CMV) epidemiology and awareness

(2009) Michael J. Cannon   JOURNAL OF CLINICAL VIROLOGY

Epigenetics: Connecting Environment and Genotype to Phenotype and Disease

(2009) S.P. Barros et al.   JOURNAL OF DENTAL RESEARCH

New Insights into the Molecular Basis of T Cell Anergy: Anergy Factors, Avoidance Sensors, and Epigenetic Imprinting

(2009) A. D. Wells   JOURNAL OF IMMUNOLOGY

The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD8+ T Cell Response

(2009) R. S. Akondy et al.   JOURNAL OF IMMUNOLOGY

Polyfunctional CD4+ T-Cell Induction in Neutralizing Antibody-Triggered Control of Simian Immunodeficiency Virus Infection

(2009) T. Yamamoto et al.   JOURNAL OF VIROLOGY

Isolation of Human Monoclonal Antibodies That Potently Neutralize Human Cytomegalovirus Infection by Targeting Different Epitopes on the gH/gL/UL128-131A Complex

(2009) A. Macagno et al.   JOURNAL OF VIROLOGY

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Direct control of mitochondrial function by mTOR

(2009) Arvind Ramanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccination in the elderly: an immunological perspective

(2009) Wilbur H. Chen et al.   TRENDS IN IMMUNOLOGY

An evolutionary perspective on the mechanisms of immunosenescence

(2009) Daryl P. Shanley et al.   TRENDS IN IMMUNOLOGY

The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses

(2009) Christina Paulus et al.   Viruses-Basel

Aging Augments IL-17 T-Cell Alloimmune Responses

(2008) B. M. Tesar et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Age-related difference of site-specific histone modifications in rat liver

(2008) Kyojiro Kawakami et al.   BIOGERONTOLOGY

The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20–100 years of age

(2008) Anders Wikby et al.   BIOGERONTOLOGY

T cell subset-specific susceptibility to aging

(2008) Marta Czesnikiewicz-Guzik et al.   CLINICAL IMMUNOLOGY

Biology of Immune Responses to Vaccines in Elderly Persons

(2008) Birgit Weinberger et al.   CLINICAL INFECTIOUS DISEASES

Nuclear factor-κB-dependent reversal of aging-induced alterations in T cell cytokines

(2008) Mei-Chuan Huang et al.   FASEB JOURNAL

Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines

(2008) Joseph D. Miller et al.   IMMUNITY

Human cytomegalovirus serum neutralizing antibodies block virus infection of endothelial/epithelial cells, but not fibroblasts, early during primary infection

(2008) G. Gerna et al.   JOURNAL OF GENERAL VIROLOGY

Decline in genomic DNA methylation through aging in a cohort of elderly subjects

(2008) Valentina Bollati et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Cytomegalovirus and human immunosenescence

(2008) Graham Pawelec et al.   REVIEWS IN MEDICAL VIROLOGY

Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people

(2008) Sven Koch et al.   Immunity & Ageing

The immune system in extreme longevity

(2007) P. Sansoni et al.   EXPERIMENTAL GERONTOLOGY