Function and regulation of the divisome for mitochondrial fission

Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology

(2020) Robert G. Abrisch et al.   JOURNAL OF CELL BIOLOGY

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial fragmentation enables localized signaling required for cell repair

(2020) Adam Horn et al.   JOURNAL OF CELL BIOLOGY

Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division

(2020) Shun Nagashima et al.   SCIENCE

Reciprocal Regulation of Mitochondrial Fission and Fusion

(2020) Rasha Sabouny et al.   TRENDS IN BIOCHEMICAL SCIENCES

Clinical-genetic features and peculiar muscle histopathology in infantile DNM1L -related mitochondrial epileptic encephalopathy

(2019) Daniela Verrigni et al.   HUMAN MUTATION

Calcium-induced transformation of cardiolipin nanodisks

(2019) Colin A. Fox et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer

(2019) Gianluca Civenni et al.   Cell Metabolism

Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline

(2019) Toby Lieber et al.   NATURE

Ultrastructure and dynamics of the actin−myosin II cytoskeleton during mitochondrial fission

(2019) Changsong Yang et al.   NATURE CELL BIOLOGY

A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii

(2019) Carmen Melatti et al.   PLoS Pathogens

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity

(2019) Philipp Hammerschmidt et al.   CELL

Mitochondrial fission requires DRP1 but not dynamins

(2019) Tiago Branco Fonseca et al.   NATURE

Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1

(2019) Katja Faelber et al.   NATURE

The Structural Biology of the Dynamin‐Related Proteins: New Insights into a Diverse, Multi‐Talented Family

(2019) Marijn G.J. Ford et al.   TRAFFIC

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

(2019) Giulia Favaro et al.   Nature Communications

Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

(2019) Sarbajeet Nagdas et al.   Cell Reports

Live-cell STED nanoscopy of mitochondrial cristae

(2019) Till Stephan et al.   Scientific Reports

Mitochondrial dynamics and interorganellar communication in the development and dysmorphism of mammalian oocytes

(2019) Osamu Udagawa et al.   JOURNAL OF BIOCHEMISTRY

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

(2018) Tatsuya Yamada et al.   Cell Metabolism

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics

(2018) Karen Schmitt et al.   Cell Metabolism

A novel mechanism causing imbalance of mitochondrial fusion and fission in human myopathies

(2018) Marina Bartsakoulia et al.   HUMAN MOLECULAR GENETICS

A brain-enriched Drp1 isoform associates with lysosomes, late endosomes and the plasma membrane

(2018) Kie Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence

(2018) Young-Mee Kim et al.   Cell Reports

Structural basis of mitochondrial receptor binding and constriction by DRP1

(2018) Raghav Kalia et al.   NATURE

Cryo-EM of the dynamin polymer assembled on lipid membrane

(2018) Leopold Kong et al.   NATURE

Structure of a mitochondrial fission dynamin in the closed conformation

(2018) Olga Bohuszewicz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission–associated myocardial senescence

(2018) Akiyuki Nishimura et al.   Science Signaling

Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission

(2018) Sukrut C. Kamerkar et al.   Nature Communications

Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming

(2018) Luca Simula et al.   Cell Reports

INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division

(2017) Rajarshi Chakrabarti et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

(2017) Jonathon L. Burman et al.   JOURNAL OF CELL BIOLOGY

Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells

(2017) Joseph L. Costello et al.   JOURNAL OF CELL SCIENCE

The constriction and scission machineries involved in mitochondrial fission

(2017) Felix Kraus et al.   JOURNAL OF CELL SCIENCE

Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension

(2017) Lian Tian et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5–dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics

(2017) Edward Cherok et al.   MOLECULAR BIOLOGY OF THE CELL

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1

(2017) Masahiro Morita et al.   MOLECULAR CELL

Use of the supported membrane tube assay system for real-time analysis of membrane fission reactions

(2017) Srishti Dar et al.   Nature Protocols

Archaea and the origin of eukaryotes

(2017) Laura Eme et al.   NATURE REVIEWS MICROBIOLOGY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fission and Fusion of Plant Mitochondria, and Genome Maintenance

(2017) Shin-ichi Arimura   PLANT PHYSIOLOGY

The Interplay of Axonal Energy Homeostasis and Mitochondrial Trafficking and Anchoring

(2017) Zu-Hang Sheng   TRENDS IN CELL BIOLOGY

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

(2017) Anil Rana et al.   Nature Communications

Cryo-EM Studies of Drp1 Reveal Cardiolipin Interactions that Activate the Helical Oligomer

(2017) Christopher A. Francy et al.   Scientific Reports

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

The coming of age of the mitochondria–ER contact: a matter of thickness

(2016) M Giacomello et al.   CELL DEATH AND DIFFERENTIATION

Membrane fission by dynamin: what we know and what we need to know

(2016) Bruno Antonny et al.   EMBO JOURNAL

Drp1, Mff, Fis1, and MiD51 are coordinated to mediate mitochondrial fission during UV irradiation–induced apoptosis

(2016) Zhenzhen Zhang et al.   FASEB JOURNAL

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling

(2016) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission

(2016) Laura D. Osellame et al.   JOURNAL OF CELL SCIENCE

Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy

(2016) Johannes Koch et al.   JOURNAL OF MEDICAL GENETICS

Actin filaments as dynamic reservoirs for Drp1 recruitment

(2016) Anna L. Hatch et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein

(2016) Shan Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Coincident Phosphatidic Acid Interaction Restrains Drp1 in Mitochondrial Division

(2016) Yoshihiro Adachi et al.   MOLECULAR CELL

Multiple dynamin family members collaborate to drive mitochondrial division

(2016) Jason E. Lee et al.   NATURE

Splitsville: structural and functional insights into the dynamic bacterial Z ring

(2016) Daniel P. Haeusser et al.   NATURE REVIEWS MICROBIOLOGY

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

(2016) Samantha C. Lewis et al.   SCIENCE

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

(2016) Javier Prieto et al.   Nature Communications

Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

(2016) Andrew S. Moore et al.   Nature Communications

Calcineurin Links Mitochondrial Elongation with Energy Metabolism

(2015) Paul T. Pfluger et al.   Cell Metabolism

Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration

(2015) Lixiang Wang et al.   DIABETOLOGIA

Dynamin-related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-anchored Mitochondrial Fission Factor

(2015) Ryan W. Clinton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity

(2015) Patrick J. Macdonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of ER-mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells

(2015) K. D. Elgass et al.   JOURNAL OF CELL SCIENCE

Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission

(2015) Natalia Stepanyants et al.   MOLECULAR BIOLOGY OF THE CELL

The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1

(2015) Raymond Liu et al.   MOLECULAR BIOLOGY OF THE CELL

MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death

(2015) Julien Prudent et al.   MOLECULAR CELL

Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors

(2015) Madhavika N. Serasinghe et al.   MOLECULAR CELL

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

(2015) Jennifer A. Kashatus et al.   MOLECULAR CELL

Crystal structure of the dynamin tetramer

(2015) Thomas F. Reubold et al.   NATURE

A high-throughput platform for real-time analysis of membrane fission reactions reveals dynamin function

(2015) Srishti Dar et al.   NATURE CELL BIOLOGY

Mitochondrial control by DRP1 in brain tumor initiating cells

(2015) Qi Xie et al.   NATURE NEUROSCIENCE

Structure and function of ER membrane contact sites with other organelles

(2015) Melissa J. Phillips et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The bacterial divisome: ready for its close-up

(2015) Veronica W. Rowlett et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Ancient dynamin segments capture early stages of host–mitochondrial integration

(2015) Ramya Purkanti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure and functional analysis of MiD49, a receptor for the mitochondrial fission protein Drp1

(2015) Oliver C. Losón et al.   PROTEIN SCIENCE

Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons

(2015) L Y Shields et al.   Cell Death & Disease

A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

(2015) Uri Manor et al.   eLife

A Role for Myosin II in Mammalian Mitochondrial Fission

(2014) Farida Korobova et al.   CURRENT BIOLOGY

The small GTPase Arf1 modulates mitochondrial morphology and function

(2014) K. B. Ackema et al.   EMBO JOURNAL

Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission

(2014) Viviane Richter et al.   JOURNAL OF CELL BIOLOGY

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission

(2014) Sunan Li et al.   JOURNAL OF CELL BIOLOGY

Specific Interaction with Cardiolipin Triggers Functional Activation of Dynamin-Related Protein 1

(2014) Itsasne Bustillo-Zabalbeitia et al.   PLoS One

Optimized two-color super resolution imaging of Drp1 during mitochondrial fission with a slow-switching Dronpa variant

(2014) A. B. Rosenbloom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitochondrial Fission Receptor MiD51 Requires ADP as a Cofactor

(2014) Oliver C. Losón et al.   STRUCTURE

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

New insights into the function and regulation of mitochondrial fission

(2013) Hidenori Otera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Adaptor Proteins MiD49 and MiD51 Can Act Independently of Mff and Fis1 in Drp1 Recruitment and Are Specific for Mitochondrial Fission

(2013) Catherine S. Palmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations in Fis1 disrupt orderly disposal of defective mitochondria

(2013) Qinfang Shen et al.   MOLECULAR BIOLOGY OF THE CELL

Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission

(2013) S. Koirala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

Mitochondrial morphology in mitophagy and macroautophagy

(2012) Ligia C. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial disease and epilepsy

(2012) SHAMIMA RAHMAN   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Allosteric Modulation of Drp1 Mechanoenzyme Assembly and Mitochondrial Fission by the Variable Domain

(2012) Stefan Strack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

MiD49 and MiD51, new components of the mitochondrial fission machinery

(2011) Catherine S Palmer et al.   EMBO REPORTS

Structure of Myxovirus Resistance Protein A Reveals Intra- and Intermolecular Domain Interactions Required for the Antiviral Function

(2011) Song Gao et al.   IMMUNITY

Crystal structure of nucleotide-free dynamin

(2011) Katja Faelber et al.   NATURE

The crystal structure of dynamin

(2011) Marijn G. J. Ford et al.   NATURE

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1

(2010) Chuang-Rung Chang et al.   Annals of the New York Academy of Sciences

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

An intimate liaison: spatial organization of the endoplasmic reticulum–mitochondria relationship

(2010) Olga Martins de Brito et al.   EMBO JOURNAL

Regulation of mitochondrial biogenesis

(2010) François R. Jornayvaz et al.   Essays in Biochemistry

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

G domain dimerization controls dynamin's assembly-stimulated GTPase activity

(2010) Joshua S. Chappie et al.   NATURE

Coordinated Actions of Actin and BAR Proteins Upstream of Dynamin at Endocytic Clathrin-Coated Pits

(2009) Shawn Ferguson et al.   DEVELOPMENTAL CELL

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

Mechanistic Analysis of a Dynamin Effector

(2009) L. L. Lackner et al.   SCIENCE

Control of mitochondrial transport and localization in neurons

(2009) Andrew F. MacAskill et al.   TRENDS IN CELL BIOLOGY

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells

(2008) Shilpa Gandre-Babbe et al.   MOLECULAR BIOLOGY OF THE CELL

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA