Article
Medicine, General & Internal
Camilla Elefante, Giulio Emilio Brancati, Silvia Bacciardi, Sonia Mazzucchi, Eleonora Del Prete, Giovanni Palermo, Daniela Frosini, Ubaldo Bonuccelli, Roberto Ceravolo, Lorenzo Lattanzi, Icro Maremmani, Giulio Perugi
Summary: Mood and anxiety disorders are common neuropsychiatric syndromes associated with Parkinson's disease. Patients with anxiety disorders in PD tend to have a history of psychiatric symptoms, lifetime major depression, and higher anxiety scores. Current anxiety disorders in PD are linked to more severe psychopathology, depressive symptoms, and avoidant behavior.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Shuichiro Neshige, Tomohiko Ohshita, Ryuji Neshige, Hirofumi Maruyama
Summary: Although a previous smoking history had a neuroprotective effect prior to onset of PD, the association between the previous history and current phenotype in PD was not visible in the present study. However, the possibility that current nicotine intake might modify the parkinsonism deterioration will need to be further evaluated, especially in non-elderly patients. Cigarette smoke-related negative mood could be a confounder for quitting smoking in PD patients.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Coralie de Hemptinne, Witney Chen, Caroline A. Racine, Andreea L. Seritan, Andrew M. Miller, Maria S. Yaroshinsky, Sarah S. Wang, Roee Gilron, Simon Little, Ian Bledsoe, Marta San Luciano, Maya Katz, Edward F. Chang, Heather E. Dawes, Jill L. Ostrem, Philip A. Starr
Summary: The study found that beta spectral power in the prefrontal cortex of PD patients correlates with symptoms of depression and anxiety, providing a physiological basis for these non-motor features. This may be useful in the development of neurostimulation paradigms for anxiety and depression in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Health Care Sciences & Services
Xuan Cao, Fang Yang, Jingyi Zheng, Xiao Wang, Qingling Huang
Summary: A new imaging technique using whole-brain structural MRI data was proposed to discriminate between depressed and non-depressed Parkinson's disease patients, and to identify the most relevant brain regions. This technique performs well without any prior feature information and is valuable for supporting the radiological diagnosis of comorbidity of depression with Parkinson's disease.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Clinical Neurology
Giuseppe Cosentino, Micol Avenali, Antonio Schindler, Nicole Pizzorni, Cristina Montomoli, Giovanni Abbruzzese, Angelo Antonini, Filippo Barbiera, Marco Benazzo, Eduardo Elias Benarroch, Giulia Bertino, Emanuele Cereda, Pere Clave, Pietro Cortelli, Roberto Eleopra, Chiara Ferrari, Shaheen Hamdy, Maggie-Lee Huckabee, Leonardo Lopiano, Rosario Marchese Ragona, Stefano Masiero, Emilia Michou, Antonio Occhini, Claudio Pacchetti, Ronald F. Pfeiffer, Domenico A. Restivo, Mariangela Rondanelli, Giovanni Ruoppolo, Giorgio Sandrini, Anthony H. Schapira, Fabrizio Stocchi, Eduardo Tolosa, Francesca Valentino, Mauro Zamboni, Roberta Zangaglia, Mario Zappia, Cristina Tassorelli, Enrico Alfonsi
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor dysfunction, with dysphagia being a common yet often underdiagnosed symptom. A multinational group of experts conducted a systematic review and consensus conference to provide guidance on the screening, diagnosis, and impact of dysphagia on the prognosis and quality of life of PD patients. The consensus statements offer a framework for timely detection and accurate diagnosis of dysphagia in PD.
JOURNAL OF NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Oskar Flygare, Julia Boberg, Christian Ruck, Robin Hofmann, Margret Leosdottir, David Mataix-Cols, Lorena Fernandez de la Cruz, Peter Richman, John Wallert
Summary: This nationwide cohort study examined the association of previous psychiatric diagnosis or self-reported symptoms of anxiety or depression with cardiovascular outcomes and mortality in patients after myocardial infarction. The results showed that both previous diagnosis and present symptoms were associated with an increased risk of death and recurrent cardiovascular events, and screening for present symptoms alone is inadequate to assess this excessive risk.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Clinical Neurology
S. M. Cartella, C. Terranova, V. Rizzo, A. Quartarone, P. Girlanda
Summary: The article discusses the relationship between Covid-19 and Parkinson's Disease, focusing on five aspects: the increased risk of severe Covid-19 infection for frail, old, multi-pathological patients; the impact on PD patients' health and risk of developing severe Covid-19; the consequences of lockdown and restrictive measures on mental and cognitive health of patients and caregivers; considerations for patient care and management during this unprecedented time; and the possibility of Covid-19-induced parkinsonism.
JOURNAL OF NEUROLOGY
(2021)
Review
Geriatrics & Gerontology
Hendrik Lintel, Timothy Corpuz, Saif-Ur-Rahman Paracha, George T. Grossberg
Summary: Mood disorders and anxiety significantly impact the prognosis and disease course of Parkinson's disease, with overlapping symptoms making accurate diagnosis difficult. Treatment options for these conditions can lead to motor complications and reduced quality of life for patients.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2021)
Article
Clinical Neurology
Carlijn D. J. M. Borm, Mario Werkmann, Debbie de Graaf, Femke Visser, Arno Hofer, Marina Peball, Katarzyna Smilowska, Diana Putz, Klaus Seppi, Werner Poewe, Carel Hoyng, Bastiaan R. Bloem, Thomas Theelen, Nienke M. de Vries
Summary: Ophthalmological disorders are common and frequently disabling for people with Parkinson's disease, but little is known about the prevalence, severity, and impact of these disorders. A study conducted on 102 patients found that almost all patients (92%) had one or more clinically relevant ophthalmological disorders, with a majority of them being potentially vision-threatening diseases.
JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Diego Santos-Garcia, Fonticoba T. De Deus, Bartolome C. Cores, Aymerich L. Valdes, Castro E. Suarez, Angel Aneiros, Silvia Jesus, Miquel Aguilar, Pau Pastor, Lluis Planellas, Marina Cosgaya, Caldente J. Garcia, Nuria Caballol, Ines Legarda, Vara J. Hernandez, Iria Cabo, Manzanares L. Lopez, Aramburu I. Gonzalez, Rivera M. A. Avila, Catalan M. Jose, Victor Nogueira, Victor Puente, Moreno J. M. Garcia, Carmen Borrue, Vila B. Solano, Sauco M. Alvarez, Lydia Vela, Sonia Escalante, Esther Cubo, Padilla F. Carrillo, Castrillo J. C. Martinez, Alonso P. Sanchez, Losada M. G. Alonso, Ariztegui N. Lopez, Itziar Gaston, Jaime Kulisevsky, Estrada M. Blazquez, Manuel Seijo, Martinez J. Ruiz, Caridad Valero, Monica Kurtis, Oriol de Fabregues-Boixar, Ardura J. Gonzalez, Jurczynska C. Prieto, Diaz L. Lopez, Darrian McAfee, Pablo Mir
Summary: This study investigated the frequency of depression, mood related factors, and the contribution of mood to a Parkinson's disease patient's quality of life perception. It found that the impact of mood on QoL perception is greater in patients with longer disease duration.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Dermatology
Jingying Wang, Haixi Wu, Weiting Cong, Haiqin Zhu, Jie Zheng, Xia Li, Meng Pan
Summary: Due to the long disease duration, impact on appearance, social stigmatization, and numerous side effects of treatment, pemphigus, an autoimmune bullous disease, often has a significant psychological impact on patients. On the other hand, mood disorders may exacerbate the disease by affecting the patient's self-management, forming a vicious circle. The study found that pemphigus patients have a high prevalence and severity of mood disorders, with depressive disorder levels significantly higher than in psoriasis patients. Disease-related hospitalization history, active mucosal damage, and concomitant thyroid disease were identified as independent risk factors for mood disorders in pemphigus patients.
JOURNAL OF DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Keelan Jagaran, Moganavelli Singh
Summary: Neurodegenerative disorders result in the gradual degeneration of axons and neurons in the central nervous system, causing major disruptions in patients' lives. Current treatments are only palliative, highlighting the need for a therapeutic strategy targeting the root cause of the diseases. The synergistic use of gene therapy and nanomedicine shows promise in effectively treating these diseases by targeting the causative mutated genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Iven-Alex von Mucke-Heim, Jan M. Deussing
Summary: Psychiatric disorders are highly burdensome worldwide, with many patients experiencing treatment resistance. Recent research has revealed the importance of neuroimmune systems in mood disorder biology, specifically the dysregulation in neuroimmune cross-talk driven by genetic risk factors and environmental influences. One emerging immune target is purinergic signalling via the P2X7 receptor (P2X7R). However, no clinically meaningful applications have been identified so far, highlighting the need for further research and translation of findings from bench to bedside.
Review
Behavioral Sciences
Eduardo Duarte-Silva, Alice Chevrollier Oria, Ingrid Prata Mendonca, Michel Gomes de Melo, Igor Henrique R. Paiva, Michael Maes, Samia R. L. Joca, Christina Alves Peixoto
Summary: Extracellular Vesicles (EVs) are small vesicles used by cells to communicate with each other and can change the function and state of cells. EVs have been implicated in the development and progression of various diseases, and understanding their roles is crucial for treatment and early diagnosis.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Vanessa Brzoskowski dos Santos, Annelise Ayres, Maiara Lais Mallmann Kieling, Elaine Cristina Miglorini, Laura Bannach Jardim, Artur Francisco Schumacher-Schuh, Carlos Roberto de Mello Rieder, Raphael Machado de Castilhos, Kristie Spencer, Rui Rothe-Neves, Maira Rozenfeld Olchik
Summary: This study compared the articulatory patterns between patients with cerebellar disorders and basal ganglia disorders. The results showed that patients with Parkinson's disease exhibited significantly lower levels in the number of syllables, phonation time, diadochokinesis, and monolog tasks. In contrast, patients with spinocerebellar ataxia type 3 only had significantly lower number of syllables in the monolog. These findings suggest a relationship between speech and general motor functioning.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)