Niclosamide affects intracellular TDP-43 distribution in motor neurons, activates mitophagy, and attenuates morphological changes under stress

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

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Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

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Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD

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Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson’s disease

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Niclosamide: Beyond an antihelminthic drug

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The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

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Niclosamide, a Drug with Many (Re)purposes

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Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

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Mitophagy in neurodegenerative diseases

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Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?

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Chemical Strategies for Activating PINK1, a Protein Kinase Mutated in Parkinson’s Disease

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Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy

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Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

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The role of mitochondria in amyotrophic lateral sclerosis

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Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro

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Amyotrophic lateral sclerosis

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The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation

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The role of STAT3 in autophagy

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(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

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TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca2+ signaling in motor neurons

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How to make spinal motor neurons

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PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease

(2014) Agne Kazlauskaite et al.   FEBS Journal

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

STAT3 Modulation to Enhance Motor Neuron Differentiation in Human Neural Stem Cells

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TARDBPandFUSMutations Associated with Amyotrophic Lateral Sclerosis: Summary and Update

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A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells

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(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Accelerated Disease Onset with Stabilized Familial Amyotrophic Lateral Sclerosis (ALS)-linked Mutant TDP-43 Proteins

(2012) Shoji Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

(2012) N. Egawa et al.   Science Translational Medicine

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

Regulation of Autophagy by Neuropathological Protein TDP-43

(2011) Jayarama Krishnan Bose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

(2011) Edward B. Lee et al.   NATURE REVIEWS NEUROSCIENCE

Autophagy and polyglutamine diseases

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Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases

(2010) Maurizio Renna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Niclosamide Prevents the Formation of Large Ubiquitin-Containing Aggregates Caused by Proteasome Inhibition

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Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway

(2010) Xiaomei Ren et al.   ACS Medicinal Chemistry Letters