Is the Macrophage Phenotype Determinant for Fibrosis Development?

MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program

(2021) Yi Wang et al.   Science Advances

M2-like macrophage infiltration and transforming growth factor-β secretion during socket healing process in mice

(2021) Kanji Horibe et al.   ARCHIVES OF ORAL BIOLOGY

Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives

(2021) Gwenda F Vasse et al.   JOURNAL OF PATHOLOGY

Immunophenotypical Characterization of M1/M2 Macrophages and Lymphocytes in Cisplatin-Induced Rat Progressive Renal Fibrosis

(2021) Minto Nakagawa et al.   Cells

Novel mechanisms and clinical trial endpoints in intestinal fibrosis*

(2021) Jie Wang et al.   IMMUNOLOGICAL REVIEWS

Hepatic macrophages: key players in the development and progression of liver fibrosis

(2021) Da Cheng et al.   LIVER INTERNATIONAL

Macrophages in Chronic Liver Failure: Diversity, Plasticity and Therapeutic Targeting

(2021) Arjuna Singanayagam et al.   Frontiers in Immunology

Role of Ferroptosis in Lung Diseases

(2021) Wenting Xu et al.   Journal of Inflammation Research

Small molecules against the origin and activation of myofibroblast for renal interstitial fibrosis therapy

(2021) Ya-long Feng et al.   BIOMEDICINE & PHARMACOTHERAPY

Pinocembrin inhibited cardiomyocyte pyroptosis against doxorubicin-induced cardiac dysfunction via regulating Nrf2/Sirt3 signaling pathway

(2021) Jiwei Gu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Liver Injury and the Macrophage Issue: Molecular and Mechanistic Facts and Their Clinical Relevance

(2021) Siyer Roohani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis

(2021) Bo Zhang et al.   Cell Death & Disease

Stem cells in the treatment of renal fibrosis: a review of preclinical and clinical studies of renal fibrosis pathogenesis

(2021) Yiping Liu et al.   Stem Cell Research & Therapy

Role of Macrophages and Related Cytokines in Kidney Disease

(2021) Elena Cantero-Navarro et al.   Frontiers in Medicine

Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation

(2021) Yufei Yan et al.   Biomedicines

Backstage players of fibrosis: NOX4, mTOR, HDAC, and S1P; companions of TGF-β

(2021) Alexis Paulina Jiménez-Uribe et al.   CELLULAR SIGNALLING

LC3-associated phagocytosis in myeloid cells, a fireman that restrains inflammation and liver fibrosis, via immunoreceptor inhibitory signaling

(2020) JingHong Wan et al.   Autophagy

Interleukin-34 Stimulates Gut Fibroblasts to Produce Collagen Synthesis

(2020) Eleonora Franzè et al.   Journal of Crohns & Colitis

Collagen microarchitecture mechanically controls myofibroblast differentiation

(2020) Bo Ri Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell death in the gut epithelium and implications for chronic inflammation

(2020) Jay V. Patankar et al.   Nature Reviews Gastroenterology & Hepatology

P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells

(2020) Min Jiang et al.   TOXICOLOGY LETTERS

Cell Death in Liver Diseases: A Review

(2020) Layla Shojaie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice

(2019) Jinbo Guo et al.   Journal of Immunology Research

Pathogenesis of fibrostenosing Crohn's disease

(2019) Jiannan Li et al.   Translational Research

Cardiac fibrosis: potential therapeutic targets

(2019) Shuin Park et al.   Translational Research

Macrophage Smad3 Protects the Infarcted Heart, Stimulating Phagocytosis and Regulating Inflammation

(2019) Bijun Chen et al.   CIRCULATION RESEARCH

Bone marrow‐derived macrophage contributes to fibrosing steatohepatitis through activating hepatic stellate cells

(2019) Juqiang Han et al.   JOURNAL OF PATHOLOGY

CD5L is a pleiotropic player in liver fibrosis controlling damage, fibrosis and immune cell content

(2019) Cristina Bárcena et al.   EBioMedicine

IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis

(2019) A. Gungl et al.   EUROPEAN RESPIRATORY JOURNAL

Fra-2–expressing macrophages promote lung fibrosis

(2019) Alvaro C. Ucero et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage Polarization in Physiological and Pathological Pregnancy

(2019) Yongli Yao et al.   Frontiers in Immunology

IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling

(2019) Andrew C. Little et al.   Frontiers in Oncology

Editorial: Alveolar Macrophages in Lung Inflammation and Resolution

(2019) Guochang Hu et al.   Frontiers in Immunology

Inflammatory macrophages switch to CCL17‐expressing phenotype and promote peritoneal fibrosis

(2019) Yi‐Ting Chen et al.   JOURNAL OF PATHOLOGY

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction

(2019) Sarah McLaughlin et al.   Nature Communications

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

(2019) Bishuang Cai et al.   Cell Metabolism

PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target

(2019) Shaoping She et al.   JOURNAL OF HEPATOLOGY

Activin-A causes Hepatic stellate cell activation via the induction of TNFα and TGFβ in Kupffer cells

(2018) Foteini Kiagiadaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

High mobility group box-1 drives fibrosis progression signaling via the receptor for advanced glycation end-products in mice

(2018) Xiaodong Ge et al.   HEPATOLOGY

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

(2018) Oliver Krenkel et al.   HEPATOLOGY

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The perivascular origin of pathological fibroblasts

(2018) Selene E. Di Carlo et al.   JOURNAL OF CLINICAL INVESTIGATION

CD16+ Macrophages Mediate Fibrosis in Inflammatory Bowel Disease

(2018) Pedro Salvador et al.   Journal of Crohns & Colitis

Inflammation and fibrosis

(2018) Matthias Mack   MATRIX BIOLOGY

The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

(2018) Pardis Pakshir et al.   MATRIX BIOLOGY

Cellular and molecular mechanisms of kidney fibrosis

(2018) Sonja Djudjaj et al.   MOLECULAR ASPECTS OF MEDICINE

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

(2018) Ralf Weiskirchen et al.   MOLECULAR ASPECTS OF MEDICINE

Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages

(2018) Juanjuan Zhao et al.   PLoS One

Myeloid-specific targeting of Notch ameliorates murine renal fibrosis via reduced infiltration and activation of bone marrow-derived macrophage

(2018) Yali Jiang et al.   Protein & Cell

Macrophage Depletion Lowered Blood Pressure and Attenuated Hypertensive Renal Injury and Fibrosis

(2018) Lei Huang et al.   Frontiers in Physiology

TGF-β receptors: In and beyond TGF-β signaling

(2018) Alexandra Vander Ark et al.   CELLULAR SIGNALLING

Cardiac fibrosis: new insights into the pathogenesis

(2018) Zhen-Guo Ma et al.   International Journal of Biological Sciences

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis

(2018) Jiwei Hou et al.   Cell Communication and Signaling

Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation

(2018) Kristina Scheibe et al.   GASTROENTEROLOGY

TGF-β1 secreted by M2 phenotype macrophages enhances the stemness and migration of glioma�cells via the SMAD2/3 signalling pathway

(2018) Zhengzheng Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Role of Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease

(2018) Sara Lovisa et al.   Journal of Crohns & Colitis

Succinate receptor mediates intestinal inflammation and fibrosis

(2018) Dulce C. Macias-Ceja et al.   Mucosal Immunology

Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants

(2018) Debra L Laskin et al.   TOXICOLOGICAL SCIENCES

Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection

(2018) Paula Saz-Leal et al.   Cell Reports

Krebs cycle rewired for macrophage and dendritic cell effector functions

(2017) Dylan Gerard Ryan et al.   FEBS LETTERS

Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases

(2017) Florian Rieder et al.   GASTROENTEROLOGY

Hepatitis C virus-induced CCL5 secretion from macrophages activates hepatic stellate cells

(2017) Reina Sasaki et al.   HEPATOLOGY

Oncostatin M causes liver fibrosis by regulating cooperation between hepatic stellate cells and macrophages in mice

(2017) Michitaka Matsuda et al.   HEPATOLOGY

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatic stellate cells secreting WFA+ -M2BP: Its role in biological interactions with Kupffer cells

(2017) Yuki Bekki et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice

(2017) Peng-Fei Ma et al.   JOURNAL OF HEPATOLOGY

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

(2017) Lara Campana et al.   JOURNAL OF IMMUNOLOGY

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

(2017) Ying-Ying Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

NF-κB pathways are involved in M1 polarization of RAW 264.7 macrophage by polyporus polysaccharide in the tumor microenvironment

(2017) Chun-Ping Liu et al.   PLoS One

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice

(2017) Yusuke Shintani et al.   Scientific Reports

Instructing Human Macrophage Polarization by Stiffness and Glycosaminoglycan Functionalization in 3D Collagen Networks

(2017) Markus Friedemann et al.   Advanced Healthcare Materials

Fibroblast fate regulation by time dependent TGF-β1 and IL-10 stimulation in biomimetic 3D matrices

(2017) Jiranuwat Sapudom et al.   Biomaterials Science

The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis

(2017) Lucy A. Murtha et al.   Frontiers in Physiology

CCR2 contributes to the recruitment of monocytes and leads to kidney inflammation and fibrosis development

(2017) Tarcio Teodoro Braga et al.   INFLAMMOPHARMACOLOGY

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

(2016) Jing Wang et al.   CELL

The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis

(2016) Yu Bo Yang Sun et al.   DIFFERENTIATION

Increased Expression of Interleukin-36, a Member of the Interleukin-1 Cytokine Family, in Inflammatory Bowel Disease

(2016) Atsushi Nishida et al.   INFLAMMATORY BOWEL DISEASES

M1 Macrophages Activate Notch Signalling in Epithelial Cells: Relevance in Crohn’s Disease

(2016) D. Ortiz-Masiá et al.   Journal of Crohns & Colitis

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

(2016) Lynette Beattie et al.   JOURNAL OF HEPATOLOGY

Monocyte and macrophage contributions to cardiac remodeling

(2016) Maarten Hulsmans et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Renal recruitment of B lymphocytes exacerbates tubulointerstitial fibrosis by promoting monocyte mobilization and infiltration after unilateral ureteral obstruction

(2016) Hui Han et al.   JOURNAL OF PATHOLOGY

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

(2016) Sebastian R. Nielsen et al.   NATURE CELL BIOLOGY

Macrophages in diabetic nephropathy in patients with type 2 diabetes

(2016) Celine Q.F. Klessens et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury

(2016) Pia Rantakari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCL18 synergises with high concentrations of glucose in stimulating fibronectin production in human renal tubuloepithelial cells

(2016) Rosa M. Montero et al.   BMC Nephrology

Matrix Metalloproteinases as Therapeutic Targets for Idiopathic Pulmonary Fibrosis

(2015) Vanessa J. Craig et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis

(2015) Chahrazade Kantari-Mimoun et al.   HEPATOLOGY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Endocannabinoid System Contributes to Liver Injury and Inflammation by Activation of Bone Marrow–Derived Monocytes/Macrophages in a CB1-Dependent Manner

(2015) Ping Mai et al.   JOURNAL OF IMMUNOLOGY

The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD

(2015) J Cosín-Roger et al.   Mucosal Immunology

Diverse origins of the myofibroblast—implications for kidney fibrosis

(2015) Lucas L. Falke et al.   Nature Reviews Nephrology

Molecular and epigenetic basis of macrophage polarized activation

(2015) Chiara Porta et al.   SEMINARS IN IMMUNOLOGY

CCR2 inhibition: a panacea for diabetic kidney disease?

(2015) Matthew R Weir   Lancet Diabetes & Endocrinology

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

(2014) Timo Heidt et al.   CIRCULATION RESEARCH

Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases

(2014) Jacek Kurzepa et al.   Hepatobiliary & Pancreatic Diseases International

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Production of Type VI Collagen by Human Macrophages: A New Dimension in Macrophage Functional Heterogeneity

(2014) M. Schnoor et al.   JOURNAL OF IMMUNOLOGY

Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis

(2014) Mark A. Barnes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung

(2013) Alexander V. Misharin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis

(2013) A. Wehr et al.   JOURNAL OF IMMUNOLOGY

MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis

(2013) S. A. Gharib et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage

(2013) Thian Kui Tan et al.   LABORATORY INVESTIGATION

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(2013) Tarcio Braga et al.   MOLECULAR MEDICINE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Induction of TGF-β1 Synthesis by Macrophages in Response to Apoptotic Cells Requires Activation of the Scavenger Receptor CD36

(2013) Weipeng Xiong et al.   PLoS One

M2 Macrophages Activate WNT Signaling Pathway in Epithelial Cells: Relevance in Ulcerative Colitis

(2013) Jesús Cosín-Roger et al.   PLoS One

Cellular Mechanisms of Tissue Fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis

(2012) Michael Zeisberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Serum-Glucocorticoid Regulated Kinase 1 Regulates Alternatively Activated Macrophage Polarization Contributing to Angiotensin II–Induced Inflammation and Cardiac Fibrosis

(2012) Min Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair

(2012) Maciej Lech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A pro-fibrotic role for interleukin-4 in cardiac pressure overload

(2012) P. Kanellakis et al.   CARDIOVASCULAR RESEARCH

Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

(2012) Evaggelia Liaskou et al.   HEPATOLOGY

Regulation of inflammation by interleukin-4: a review of “alternatives”

(2012) Irina G. Luzina et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-13 Signaling in Liver Fibrogenesis

(2012) Yan Liu et al.   Frontiers in Immunology

Class A scavenger receptor attenuates myocardial infarction-induced cardiomyocyte necrosis through suppressing M1 macrophage subset polarization

(2011) Yulong Hu et al.   BASIC RESEARCH IN CARDIOLOGY

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet

(2011) Nicolas Lanthier et al.   FASEB JOURNAL

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Mannose Receptor 2 Attenuates Renal Fibrosis

(2011) J. M. Lopez-Guisa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

The origin of interstitial myofibroblasts in chronic kidney disease

(2011) Ivica Grgic et al.   PEDIATRIC NEPHROLOGY

Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells

(2010) Thian Kui Tan et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

Accelerated liver fibrosis in hepatitis B virus transgenic mice: Involvement of natural killer T cells

(2010) Zixue Jin et al.   HEPATOLOGY

Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming

(2010) Carol El Chartouni et al.   IMMUNOBIOLOGY

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

(2010) Michael G. Usher et al.   JOURNAL OF CLINICAL INVESTIGATION

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Kupffer cells promote hepatic steatosis via interleukin-1β-dependent suppression of peroxisome proliferator-activated receptor α activity

(2009) Rinke Stienstra et al.   HEPATOLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

Deletion of Mineralocorticoid Receptors From Macrophages Protects Against Deoxycorticosterone/Salt-Induced Cardiac Fibrosis and Increased Blood Pressure

(2009) Amanda J. Rickard et al.   HYPERTENSION

CCR1 and CCR5 promote hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of Liposome Clodronate on Renal Leukocyte Populations and Renal Fibrosis in Murine Obstructive Nephropathy

(2009) Koichiro Kitamoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis

(2008) Neil C. Henderson et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-10 Overexpression Decreases Inflammatory Mediators and Promotes Regenerative Healing in an Adult Model of Scar Formation

(2008) William H. Peranteau et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

(2008) Alessandro Sorrentino et al.   NATURE CELL BIOLOGY

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1

(2008) R. Eferl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY

A New Look at Platelet-Derived Growth Factor in Renal Disease

(2007) J. Floege et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY