Interleukin-34 Stimulates Gut Fibroblasts to Produce Collagen Synthesis

IL-34 regulates IL-6 and IL-8 production in human lung fibroblasts via MAPK, PI3K-Akt, JAK and NF-κB signaling pathways

(2018) Jie Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Serum interleukin-34 levels in patients with systemic sclerosis: Clinical association with interstitial lung disease

(2018) Ai Kuzumi et al.   JOURNAL OF DERMATOLOGY

Mesenchymal Cells in Colon Cancer

(2017) Vasiliki Koliaraki et al.   GASTROENTEROLOGY

IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes

(2017) Bing Wang et al.   MEDIATORS OF INFLAMMATION

Interleukin-34 sustains pro-tumorigenic signals in colon cancer tissue

(2017) Eleonora Franzè et al.   Oncotarget

Oral pirfenidone protects against fibrosis by inhibiting fibroblast proliferation and TGF-β signaling in a murine colitis model

(2016) Guanwei Li et al.   BIOCHEMICAL PHARMACOLOGY

Novel PPARγ Modulator GED-0507-34 Levo Ameliorates Inflammation-driven Intestinal Fibrosis

(2016) Silvia Speca et al.   INFLAMMATORY BOWEL DISEASES

Interleukin-34 as a fibroblast-derived marker of liver fibrosis in patients with non-alcoholic fatty liver disease

(2016) Hirotaka Shoji et al.   Scientific Reports

Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis

(2015) Jin Imai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interleukin-34 sustains inflammatory pathways in the gut

(2015) Eleonora Franzè et al.   CLINICAL SCIENCE

Interleukin 34: a new modulator of human and experimental inflammatory bowel disease

(2015) Stephanie Zwicker et al.   CLINICAL SCIENCE

Pathogenic aspects and therapeutic avenues of intestinal fibrosis in Crohn's disease

(2015) F. Zorzi et al.   CLINICAL SCIENCE

Interleukin-34 Induces Cc-chemokine Ligand 20 in Gut Epithelial Cells

(2015) Eleonora Franzè et al.   Journal of Crohns & Colitis

IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells

(2014) Laurence Preisser et al.   HEPATOLOGY

Fibroblasts in fibrosis: novel roles and mediators

(2014) Ryan T. Kendall et al.   Frontiers in Pharmacology

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

Receptor-type Protein-tyrosine Phosphatase ζ Is a Functional Receptor for Interleukin-34

(2013) Sayan Nandi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R

(2012) Xiaolei Ma et al.   STRUCTURE

Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis

(2012) Seung-Jun Hwang et al.   ARTHRITIS RESEARCH & THERAPY

Themes in fibrosis and gastrointestinal inflammation

(2011) Claudio Fiocchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Regulation of Homeostasis and Inflammation in the Intestine

(2011) Thomas T. MacDonald et al.   GASTROENTEROLOGY

The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease

(2011) Ya Jing FENG et al.   Journal of Digestive Diseases

Intestinal fibrosis in IBD—a dynamic, multifactorial process

(2009) Florian Rieder et al.   Nature Reviews Gastroenterology & Hepatology

IL-13 Signaling via IL-13Rα2 Induces Major Downstream Fibrogenic Factors Mediating Fibrosis in Chronic TNBS Colitis

(2008) Stefan Fichtner–Feigl et al.   GASTROENTEROLOGY

Fibrinogen induces cytokine and collagen production in pancreatic stellate cells

(2008) A Masamune et al.   GUT

Intestinal fibrosis in inflammatory bowel disease — Current knowledge and future perspectives

(2008) Florian Rieder et al.   Journal of Crohns & Colitis

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY