Stem cells in the treatment of renal fibrosis: a review of preclinical and clinical studies of renal fibrosis pathogenesis

Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities

(2021) Cody C. Gifford et al.   CLINICAL SCIENCE

Pro-Inflammatory Effects of Indoxyl Sulfate in Mice: Impairment of Intestinal Homeostasis and Immune Response

(2021) Shara Francesca Rapa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

(2021) Verónica Miguel et al.   JOURNAL OF CLINICAL INVESTIGATION

Fasudil suppresses renal fibrosis in diabetic rats through PI3K/AKT signaling pathway

(2021) Zenggang HAN et al.   PANMINERVA MEDICA

Targeting ROCK signaling in health, malignant and non-malignant diseases

(2020) Roya Shahbazi et al.   IMMUNOLOGY LETTERS

Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway

(2020) Yuan Liao et al.   Drug Design Development and Therapy

Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis, in part by inhibiting the RhoA/ROCK pathway, in a UUO rat model

(2020) Zhengzhou Shi et al.   Stem Cell Research & Therapy

Human umbilical cord mesenchymal stem cell attenuates renal fibrosis via TGF-β/Smad signaling pathways in vivo and in vitro

(2020) Yihang Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of calcitriol and paricalcitol on renal fibrosis in CKD

(2020) Laura Martínez-Arias et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Adipose‑derived mesenchymal stem cells inhibit cell proliferation and migration and suppress extracellular matrix synthesis in hypertrophic‑scar and keloid fibroblasts

(2020) Fang Xie et al.   Experimental and Therapeutic Medicine

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

(2019) Xiao-qiang Geng et al.   ACTA PHARMACOLOGICA SINICA

Cryptotanshinone Attenuates Oxidative Stress and Inflammation through the Regulation of Nrf-2 and NF-κB in Mice with Unilateral Ureteral Obstruction

(2018) Wei Wang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Role of Matrix Metalloproteinases in Degenerative Kidney Disorders

(2018) Shifa Narula et al.   CURRENT MEDICINAL CHEMISTRY

Regenerating the kidney using human pluripotent stem cells and renal progenitors

(2018) Francesca Becherucci et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Anti-fibrotic treatments: A review of clinical evidence

(2018) Marco Allinovi et al.   MATRIX BIOLOGY

Mesenchymal stem cells attenuate adriamycin-induced nephropathy by diminishing oxidative stress and inflammation via downregulation of the NF-kB

(2018) In-Hwan Song et al.   NEPHROLOGY

Human umbilical cord mesenchymal stem cell conditioned medium attenuates renal fibrosis by reducing inflammation and epithelial-to-mesenchymal transition via the TLR4/NF-κB signaling pathway in vivo and in vitro

(2018) Bo Liu et al.   Stem Cell Research & Therapy

Targeting Murine Mesenchymal Stem Cells to Kidney Injury Molecule-1 Improves Their Therapeutic Efficacy in Chronic Ischemic Kidney Injury

(2018) Xiangyu Zou et al.   Stem Cells Translational Medicine

Notch signaling in the collecting duct regulates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction in mice

(2018) Arum Choi et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Aloe-emodin ameliorates renal fibrosis via inhibiting PI3K/Akt/mTOR signaling pathway in vivo and in vitro

(2018) Fang Dou et al.   REJUVENATION RESEARCH

Amelioratory Effects of Testosterone Propionate on Age-related Renal Fibrosis via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2-ARE Signaling

(2018) Guoliang Zhang et al.   Scientific Reports

Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease

(2018) Cinzia Rota et al.   Stem Cell Research & Therapy

Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming

(2018) Shizheng Huang et al.   PLOS BIOLOGY

Adipose-derived stem cells ameliorate renal interstitial fibrosis through inhibition of EMT and inflammatory response via TGF-β1 signaling pathway

(2017) Yan Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Signalling pathways involved in hypoxia-induced renal fibrosis

(2017) Minna Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Micro-vesicles derived from human Wharton's Jelly mesenchymal stromal cells mitigate renal ischemia-reperfusion injury in rats after cardiac death renal transplantation

(2017) Xiaoqiang Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

(2017) Ying-Ying Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mesenchymal stem cell–derived extracellular vesicles attenuate kidney inflammation

(2017) Alfonso Eirin et al.   KIDNEY INTERNATIONAL

Impacts of the serum containing total flavonoids of Ajuga on rat glomerular mesangial cells

(2017) Lihong Nan et al.   Molecular Medicine Reports

Human Umbilical Cord-Derived Mesenchymal Stem Cells Conditioned Medium Attenuate Interstitial Fibrosis and Stimulate the Repair of Tubular Epithelial Cells in an Irreversible Model of Unilateral Ureteral Obstruction

(2017) Bo Liu et al.   NEPHROLOGY

Adipose-derived mesenchymal stem cells employed exosomes to attenuate AKI-CKD transition through tubular epithelial cell dependent Sox9 activation

(2017) Fengming Zhu et al.   Oncotarget

Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury

(2017) Camila Eleuterio Rodrigues et al.   Stem Cell Research & Therapy

Inhibition of (pro)renin Receptor Contributes to Renoprotective Effects of Angiotensin II Type 1 Receptor Blockade in Diabetic Nephropathy

(2017) Lin Zhang et al.   Frontiers in Physiology

Exression and PI3K/AKT Pathway in Gastric Cancer and its Blockade Suppresses Tumor Growth and Metastasis

(2017) B. Ye et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Effects of Bone Marrow Mesenchymal Stem Cells on Plasminogen Activator Inhibitor-1 and Renal Fibrosis in Rats with Diabetic Nephropathy

(2016) Hong Lang et al.   ARCHIVES OF MEDICAL RESEARCH

Mesenchymal Stem Cells from Wharton's Jelly and Amniotic Fluid

(2016) Marianne S. Joerger-Messerli et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis

(2016) Yu Bo Yang Sun et al.   DIFFERENTIATION

Notch Signaling and the Skeleton

(2016) Stefano Zanotti et al.   ENDOCRINE REVIEWS

Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model

(2016) Sook In Chung et al.   JOURNAL OF HEPATOLOGY

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation

(2016) Agnieszka Loboda et al.   MEDIATORS OF INFLAMMATION

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis

(2016) Bo Wang et al.   MOLECULAR THERAPY

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

(2016) Maria Edeling et al.   Nature Reviews Nephrology

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy

(2016) Ting Gong et al.   Stem Cells International

Bone Marrow-Derived Mesenchymal Stem Cells and Their Conditioned Medium Attenuate Fibrosis in an Irreversible Model of Unilateral Ureteral Obstruction

(2015) Andrei F. Da Silva et al.   CELL TRANSPLANTATION

Regulation of Renal Fibrosis by Macrophage Polarization

(2015) Bixia Pan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Assessment of intravenous adipose-derived allogeneic mesenchymal stem cells for the treatment of feline chronic kidney disease: a randomized, placebo-controlled clinical trial in eight cats

(2015) Jessica M Quimby et al.   JOURNAL OF FELINE MEDICINE AND SURGERY

CX3CL1–CX3CR1 Interaction Increases the Population of Ly6C−CX3CR1hiMacrophages Contributing to Unilateral Ureteral Obstruction–Induced Fibrosis

(2015) Xiaogang Peng et al.   JOURNAL OF IMMUNOLOGY

Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients: the neptune study

(2015) Marlies E. J. Reinders et al.   Journal of Translational Medicine

Origin of myofibroblasts and cellular events triggering fibrosis

(2015) Matthias Mack et al.   KIDNEY INTERNATIONAL

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Amniotic Fluid Derived Stem Cells with a Renal Progenitor Phenotype Inhibit Interstitial Fibrosis in Renal Ischemia and Reperfusion Injury in Rats

(2015) Marina Gabriela Monteiro Carvalho Mori da Cunha et al.   PLoS One

Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development

(2015) Sergei Y. Sokol   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TGF-β/Smad signaling in renal fibrosis

(2015) Xiao-Ming Meng et al.   Frontiers in Physiology

Adipose Tissue-Derived Stem Cells Reduce Acute and Chronic Kidney Damage in Mice

(2015) Marina Burgos-Silva et al.   PLoS One

Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury

(2015) Yuka Hattori et al.   PLoS One

Macrophages Regulate Renal Fibrosis Through Modulating TGFβ Superfamily Signaling

(2014) Bing Shen et al.   INFLAMMATION

The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation

(2014) Zhicheng Xiao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sonic Hedgehog Is a Novel Tubule-Derived Growth Factor for Interstitial Fibroblasts after Kidney Injury

(2014) D. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Blocking Notch in Endothelial Cells Prevents Arteriovenous Fistula Failure Despite CKD

(2014) Y. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autologous bone marrow derived mesenchymal stromal cell therapy in combination with everolimus to preserve renal structure and function in renal transplant recipients

(2014) Marlies EJ Reinders et al.   Journal of Translational Medicine

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

Macrophage-mediated injury and repair after ischemic kidney injury

(2014) Sarah C. Huen et al.   PEDIATRIC NEPHROLOGY

The Anti-Oxidative Role of Micro-Vesicles Derived from Human Wharton-Jelly Mesenchymal Stromal Cells through NOX2/gp91(phox) Suppression in Alleviating Renal Ischemia-Reperfusion Injury in Rats

(2014) Guangyuan Zhang et al.   PLoS One

Mesenchymal Stem Cells Modulate Albumin-Induced Renal Tubular Inflammation and Fibrosis

(2014) Hao Jia Wu et al.   PLoS One

Impact of Ex Vivo Administration of Mesenchymal Stem Cells on the Function of Kidney Grafts From Cardiac Death Donors in Rat

(2014) S. Iwai et al.   TRANSPLANTATION PROCEEDINGS

Amniotic Fluid-Derived Mesenchymal Stem Cells Prevent Fibrosis and Preserve Renal Function in a Preclinical Porcine Model of Kidney Transplantation

(2014) Edouard Baulier et al.   Stem Cells Translational Medicine

Low Serum Cultured Adipose Tissue-Derived Stromal Cells Ameliorate Acute Kidney Injury in Rats

(2013) Takayuki Katsuno et al.   CELL TRANSPLANTATION

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

(2013) Dexi Zhou et al.   CELLULAR SIGNALLING

Wnt signaling in stem and cancer stem cells

(2013) Jane D Holland et al.   CURRENT OPINION IN CELL BIOLOGY

Bone marrow-derived mesenchymal stromal cells from patients with end-stage renal disease are suitable for autologous therapy

(2013) Marlies E.J. Reinders et al.   CYTOTHERAPY

MicroRNA-29b Inhibits Diabetic Nephropathy in db/db Mice

(2013) Hai-Yong Chen et al.   MOLECULAR THERAPY

Human Adipose Tissue Derived Mesenchymal Stem Cells Aggravate Chronic Cyclosporin Nephrotoxicity by the Induction of Oxidative Stress

(2013) Byung Ha Chung et al.   PLoS One

Therapeutic Effects of Human Amniotic Fluid-Derived Stem Cells on Renal Interstitial Fibrosis in a Murine Model of Unilateral Ureteral Obstruction

(2013) Dong Sun et al.   PLoS One

Distribution of infused umbilical cord mesenchymal stem cells in a rat model of renal interstitial fibrosis

(2013) Danlin Huang et al.   RENAL FAILURE

Targeting the PI3-Kinase/Akt/mTOR Signaling Pathway

(2013) Burhan Hassan et al.   Surgical Oncology Clinics of North America

Human Wharton’s jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells

(2013) Tao Du et al.   Stem Cell Research & Therapy

Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three sequential pilot studies

(2013) Jessica M Quimby et al.   Stem Cell Research & Therapy

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

(2013) Ying Zhou et al.   Stem Cell Research & Therapy

Autologous Bone Marrow-Derived Mesenchymal Stromal Cells for the Treatment of Allograft Rejection After Renal Transplantation: Results of a Phase I Study

(2013) Marlies E.J. Reinders et al.   Stem Cells Translational Medicine

The Hedgehog System Machinery Controls Transforming Growth Factor-β–Dependent Myofibroblastic Differentiation in Humans

(2012) Natacha Cigna et al.   AMERICAN JOURNAL OF PATHOLOGY

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

(2012) Ching-Fang Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Adipose Tissue-Derived Stem Cell Treatment Prevents Renal Disease Progression

(2012) Cassiano Donizetti-Oliveira et al.   CELL TRANSPLANTATION

The alleviation of acute and chronic kidney injury by human Wharton's jelly-derived mesenchymal stromal cells triggered by ischemia-reperfusion injury via an endocrine mechanism

(2012) Tao Du et al.   CYTOTHERAPY

Three decades of Wnts: a personal perspective on how a scientific field developed

(2012) Roel Nusse et al.   EMBO JOURNAL

Induction Therapy With Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants

(2012) Jianming Tan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The myofibroblast matrix: implications for tissue repair and fibrosis

(2012) Franco Klingberg et al.   JOURNAL OF PATHOLOGY

Injection of Amniotic Fluid Stem Cells Delays Progression of Renal Fibrosis

(2012) S. Sedrakyan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Prevalence of chronic kidney disease in China: a cross-sectional survey

(2012) Luxia Zhang et al.   LANCET

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells

(2012) Rui Du et al.   PLoS One

Role of TGF-β in chronic kidney disease: an integration of tubular, glomerular and vascular effects

(2011) Francisco J. López-Hernández et al.   CELL AND TISSUE RESEARCH

TGF- /Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29

(2011) W. Qin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro

(2011) Xiao-Ming Meng et al.   KIDNEY INTERNATIONAL

The origin of interstitial myofibroblasts in chronic kidney disease

(2011) Ivica Grgic et al.   PEDIATRIC NEPHROLOGY

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH

Emergence of the Phosphoinositide 3-Kinase-Akt- Mammalian Target of Rapamycin Axis in Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition

(2010) Samy Lamouille et al.   CELLS TISSUES ORGANS

Defining the risks of mesenchymal stromal cell therapy

(2010) Darwin J. Prockop et al.   CYTOTHERAPY

High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells

(2010) Bin Du et al.   FEBS LETTERS

Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor

(2010) S. Saad et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Arterially Delivered Mesenchymal Stem Cells Prevent Obstruction-Induced Renal Fibrosis

(2010) Hiroshi Asanuma et al.   JOURNAL OF SURGICAL RESEARCH

JAK/STAT signaling in renal diseases

(2010) Peter Y. Chuang et al.   KIDNEY INTERNATIONAL

A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy

(2010) Maoyin Pang et al.   KIDNEY INTERNATIONAL

Mesenchymal stem cells: a new therapeutic tool for AKI

(2010) Florian E. Tögel et al.   Nature Reviews Nephrology

Macrophages and Renal Fibrosis

(2010) Madeleine A. Vernon et al.   SEMINARS IN NEPHROLOGY

Endothelial-Myofibroblast Transition Contributes to the Early Development of Diabetic Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice

(2009) Jinhua Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Serum Amyloid P Inhibits Fibrosis Through Fc R-Dependent Monocyte-Macrophage Regulation in Vivo

(2009) A. P. Castano et al.   Science Translational Medicine

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2

(2008) Manav Korpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY

Macrophage diversity in renal injury and repair

(2008) Sharon D. Ricardo et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

(2008) E. M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY