Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives

Human lung extracellular matrix hydrogels resemble the stiffness and viscoelasticity of native lung tissue

(2020) Roderick Harold Jan de Hilster et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A small‐molecule CD44 dimerizing inhibitor for glioblastoma treatment

(2020) Chongwu Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL

(2020) Jing Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fibrosis and cancer: A strained relationship

(2020) Bram Piersma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Control of Matrix Stiffness Using Methacrylate–Gelatin Hydrogels for a Macrophage-Mediated Inflammatory Response

(2020) Zhumei Zhuang et al.   ACS Biomaterials-Science & Engineering

LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis

(2020) Mordehay Klepfish et al.   Frontiers in Immunology

Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo

(2020) Angelina D. Schoenenberger et al.   BIOMATERIALS

Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis

(2020) Fenghua Zhang et al.   EMBO Molecular Medicine

Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis

(2020) Mingming Liu et al.   Cell Reports

Collagen Density Modulates the Immunosuppressive Functions of Macrophages

(2020) Anne Mette H. Larsen et al.   JOURNAL OF IMMUNOLOGY

YAP-mediated mechanotransduction tunes the macrophage inflammatory response

(2020) Vijaykumar S. Meli et al.   Science Advances

Immunoregulatory potential of mesenchymal stem cells following activation by macrophage-derived soluble factors

(2019) Laura Saldaña et al.   Stem Cell Research & Therapy

Biophysical regulation of macrophages in health and disease

(2019) Vijaykumar S. Meli et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Material stiffness influences the polarization state, function and migration mode of macrophages

(2019) Rukmani Sridharan et al.   Acta Biomaterialia

The Transferrin Receptor CD71 Delineates Functionally Distinct Airway Macrophage Subsets during Idiopathic Pulmonary Fibrosis

(2019) Sarah J Allden et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bone marrow‐derived macrophage contributes to fibrosing steatohepatitis through activating hepatic stellate cells

(2019) Juqiang Han et al.   JOURNAL OF PATHOLOGY

Fibroblasts stimulate macrophage migration in interconnected extracellular matrices through tunnel formation and fiber alignment

(2019) Andrew J. Ford et al.   BIOMATERIALS

Application of nintedanib and other potential anti-fibrotic agents in fibrotic diseases

(2019) Feng Liu et al.   CLINICAL SCIENCE

Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis

(2019) Christina Morse et al.   EUROPEAN RESPIRATORY JOURNAL

Alteration of human macrophage phenotypes by the anti-fibrotic drug nintedanib

(2019) Nessrine Bellamri et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

(2019) Pardis Pakshir et al.   Nature Communications

Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments

(2019) Elena Martínez-Klimova et al.   Biomolecules

Loss of cells expressing fibroblast activation protein has variable effects in models of TGF-β and chronic bleomycin-induced fibrosis

(2019) Toru Kimura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The complex dynamics of myocardial interstitial fibrosis in heart failure. Focus on collagen cross-linking

(2019) Arantxa González et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanical stretch promotes tumoricidal M1 polarization via the FAK/NF-κB signaling pathway

(2019) Shengzhou Shan et al.   FASEB JOURNAL

Quantitative Liver Fibrosis Using Collagen Hybridizing Peptide to Predict Native Liver Survival in Biliary Atresia

(2019) Catalina Jaramillo et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signaling in monocyte-derived alveolar macrophages

(2019) Nikita Joshi et al.   EUROPEAN RESPIRATORY JOURNAL

Fibrocytes and fibroblasts—Where are we now

(2019) Sy Giin Chong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inflammatory macrophages switch to CCL17‐expressing phenotype and promote peritoneal fibrosis

(2019) Yi‐Ting Chen et al.   JOURNAL OF PATHOLOGY

Periostin Promotes Cell Proliferation and Macrophage Polarization to Drive Repair after AKI

(2019) Raphaёl Kormann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Transition of Macrophages to Fibroblast-Like Cells in Healing Myocardial Infarction

(2019) Nezam Haider et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Macrophage involvement affects matrix stiffness-related influences on cell osteogenesis under three-dimensional culture conditions

(2018) Xiao-Tao He et al.   Acta Biomaterialia

Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis

(2018) Lindsay T. McDonald et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Greater cellular stiffness in fibroblasts from patients with idiopathic pulmonary fibrosis

(2018) Jade Jaffar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Extracellular Matrix Cross-Linking Enhances Fibroblast Growth and Protects against Matrix Proteolysis in Lung Fibrosis

(2018) Christopher J. Philp et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The role of TRPV4 in fibrosis

(2018) Lei Zhan et al.   GENE

Toll-like receptor signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled-coil kinase (ROCK1/2)

(2018) Erika Gruber et al.   INTERNATIONAL IMMUNOLOGY

Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts

(2018) Diana Avery et al.   MATRIX BIOLOGY

Extracellular matrix remodeling and cardiac fibrosis

(2018) Li Li et al.   MATRIX BIOLOGY

Interstitial Flow Promotes Macrophage Polarization toward an M2 Phenotype

(2018) Ran Li et al.   MOLECULAR BIOLOGY OF THE CELL

Pirfenidone ameliorates lipopolysaccharide-induced pulmonary inflammation and fibrosis by blocking NLRP3 inflammasome activation

(2018) Yi Li et al.   MOLECULAR IMMUNOLOGY

TRPV4 inhibition attenuates stretch-induced inflammatory cellular responses and lung barrier dysfunction during mechanical ventilation

(2018) N. Pairet et al.   PLoS One

The Effect of Mechanical Loading Upon Extracellular Matrix Bioscaffold-Mediated Skeletal Muscle Remodeling

(2018) Jenna L. Dziki et al.   TISSUE ENGINEERING PART A

Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue

(2018) Mithun Sinha et al.   Nature Communications

Cyclic Stretch Negatively Regulates IL-1β Secretion Through the Inhibition of NLRP3 Inflammasome Activation by Attenuating the AMP Kinase Pathway

(2018) Kentaro Maruyama et al.   Frontiers in Physiology

The role of CD44, hyaluronan and NHE1 in cardiac remodeling

(2018) Muna Suleiman et al.   LIFE SCIENCES

Unveiling the Mechanism of Surface Hydrophilicity-Modulated Macrophage Polarization

(2018) Lin Lv et al.   Advanced Healthcare Materials

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis

(2018) Jiwei Hou et al.   Cell Communication and Signaling

The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

(2018) Ye Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human monocytes and macrophages regulate immune tolerance via integrin αvβ8–mediated TGFβ activation

(2018) Aoife Kelly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

(2018) Brett A. Shook et al.   SCIENCE

Fibronectin (FN) cooperated with TLR2/TLR4 receptor to promote innate immune responses of macrophages via binding to integrin β1

(2018) Dongsheng Fei et al.   Virulence

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

(2017) Gerald Burgstaller et al.   EUROPEAN RESPIRATORY JOURNAL

TRPV4 calcium-permeable channel is a novel regulator of oxidized LDL-induced macrophage foam cell formation

(2017) Rishov Goswami et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal

(2017) Naoki Ikenaga et al.   GUT

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

(2017) Begum Erdogan et al.   JOURNAL OF CELL BIOLOGY

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pharmacologic Blockade of α v β 1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo

(2017) Yongen Chang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

(2017) Ying-Ying Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage phenotype in response to ECM bioscaffolds

(2017) Luai Huleihel et al.   SEMINARS IN IMMUNOLOGY

Alternatively activated macrophages derived from THP-1 cells promote the fibrogenic activities of human dermal fibroblasts

(2017) Zhensen Zhu et al.   WOUND REPAIR AND REGENERATION

Integrin-Mediated Interactions Control Macrophage Polarization in 3D Hydrogels

(2017) Byung-Hyun Cha et al.   Advanced Healthcare Materials

Instructing Human Macrophage Polarization by Stiffness and Glycosaminoglycan Functionalization in 3D Collagen Networks

(2017) Markus Friedemann et al.   Advanced Healthcare Materials

The influence of surface modified poly(l-lactic acid) films on the differentiation of human monocytes into macrophages

(2017) Clara R. Correia et al.   Biomaterials Science

Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice

(2017) Emilia Peuhu et al.   PLoS One

Structural environment built by AKAP12+ colon mesenchymal cells drives M2 macrophages during inflammation recovery

(2017) Jun-Mo Yang et al.   Scientific Reports

Tyrosine kinase inhibitor BIBF1120 ameliorates inflammation, angiogenesis and fibrosis in CCl4-induced liver fibrogenesis mouse model

(2017) Büsra Öztürk Akcora et al.   Scientific Reports

Feel the force: Podosomes in mechanosensing

(2016) Stefan Linder et al.   EXPERIMENTAL CELL RESEARCH

Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis

(2016) Luigi Locatelli et al.   HEPATOLOGY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

The extracellular matrix - the under-recognized element in lung disease?

(2016) Janette K Burgess et al.   JOURNAL OF PATHOLOGY

Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion

(2016) Anna Mazur et al.   PLoS One

Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs

(2016) Matthew S. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis

(2016) Xiao-Ming Meng et al.   Cell Death & Disease

Fibronectin induces macrophage migration through a SFK-FAK/CSF-1R pathway

(2016) Graziana Digiacomo et al.   Cell Adhesion & Migration

Involvement of hepatic macrophages in the antifibrotic effect of IGF-I-overexpressing mesenchymal stromal cells

(2016) Esteban Fiore et al.   Stem Cell Research & Therapy

Matricellular Protein Periostin Contributes to Hepatic Inflammation and Fibrosis

(2015) Yangmei Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

Experimental models of liver fibrosis

(2015) Sara Crespo Yanguas et al.   ARCHIVES OF TOXICOLOGY

Solubilized extracellular matrix from brain and urinary bladder elicits distinct functional and phenotypic responses in macrophages

(2015) Fan Wei Meng et al.   BIOMATERIALS

Substrate elasticity regulates the behavior of human monocyte-derived macrophages

(2015) Katrina M. Adlerz et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis

(2015) Rachel G. Scheraga et al.   JOURNAL OF IMMUNOLOGY

Lack of hyaluronidases exacerbates renal post-ischemic injury, inflammation, and fibrosis

(2015) Vanessa Colombaro et al.   KIDNEY INTERNATIONAL

Biomaterial based modulation of macrophage polarization: a review and suggested design principles

(2015) Rukmani Sridharan et al.   Materials Today

The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

(2015) Boris Hinz   MATRIX BIOLOGY

Substrate Stiffness Regulates Proinflammatory Mediator Production through TLR4 Activity in Macrophages

(2015) Michelle L. Previtera et al.   PLoS One

Mechanical Ventilation–associated Lung Fibrosis in Acute Respiratory Distress Syndrome

(2014) Nuria E. Cabrera-Benitez et al.   ANESTHESIOLOGY

The effect of thick fibers and large pores of electrospun poly(ε-caprolactone) vascular grafts on macrophage polarization and arterial regeneration

(2014) Zhihong Wang et al.   BIOMATERIALS

Biocompatibility and inflammatory response in vitro and in vivo to gelatin-based biomaterials with tailorable elastic properties

(2014) Sandra Ullm et al.   BIOMATERIALS

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells

(2014) Laurence Preisser et al.   HEPATOLOGY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Macrophage-like U937 cells recognize collagen fibrils with strain-induced discrete plasticity damage

(2014) Samuel P. Veres et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

(2014) Franco Klingberg et al.   JOURNAL OF CELL BIOLOGY

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

(2014) Matthew W. Parker et al.   JOURNAL OF CLINICAL INVESTIGATION

TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice

(2014) Shaik O. Rahaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Periostin Expression Protects against the Development of Renal Inflammation and Fibrosis

(2014) M. Mael-Ainin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Role of Extracellular Matrix Quality in Pulmonary Fibrosis

(2014) Jacob Hull Kristensen et al.   RESPIRATION

Protrusion force microscopy reveals oscillatory force generation and mechanosensing activity of human macrophage podosomes

(2014) Anna Labernadie et al.   Nature Communications

Fractionation of an ECM hydrogel into structural and soluble components reveals distinctive roles in regulating macrophage behavior

(2014) P. F. Slivka et al.   Biomaterials Science

Tissue mechanics and fibrosis

(2013) Rebecca G. Wells   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds

(2013) Koyal Garg et al.   BIOMATERIALS

 1 Integrin Targeting Potentiates Antiangiogenic Therapy and Inhibits the Growth of Bevacizumab-Resistant Glioblastoma

(2013) W. S. Carbonell et al.   CANCER RESEARCH

Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species

(2013) Rohan Samarakoon et al.   CELLULAR SIGNALLING

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Periostin expression is upregulated and associated with myocardial fibrosis in human failing hearts

(2013) Sheng Zhao et al.   Journal of Cardiology

Activation of NLRP3 Inflammasome in Alveolar Macrophages Contributes to Mechanical Stretch-Induced Lung Inflammation and Injury

(2013) J. Wu et al.   JOURNAL OF IMMUNOLOGY

Modulation of macrophage phenotype by cell shape

(2013) F. Y. McWhorter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Artificial extracellular matrices composed of collagen I and high-sulfated hyaluronan promote phenotypic and functional modulation of human pro-inflammatory M1 macrophages

(2012) Sandra Franz et al.   Acta Biomaterialia

Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis

(2012) Payal K. Naik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Extracellular Matrix Remodeling: The Common Denominator in Connective Tissue DiseasesPossibilities for Evaluation and Current Understanding of the Matrix as More Than a Passive Architecture, but a Key Player in Tissue Failure

(2012) Morten A. Karsdal et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair

(2012) Maciej Lech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cell Elasticity Determines Macrophage Function

(2012) Naimish R. Patel et al.   PLoS One

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective efferocytosis by alveolar macrophages in IPF patients

(2012) Konosuke Morimoto et al.   RESPIRATORY MEDICINE

TLR4 Activity Is Required in the Resolution of Pulmonary Inflammation and Fibrosis after Acute and Chronic Lung Injury

(2011) Hong-Zhen Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Combined stimulation with cyclic stretching and hypoxia increases production of matrix metalloproteinase-9 and cytokines by macrophages

(2011) Koki Oya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phase I Study of E7820, an Oral Inhibitor of Integrin  -2 Expression with Antiangiogenic Properties, in Patients with Advanced Malignancies

(2011) M. Mita et al.   CLINICAL CANCER RESEARCH

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice

(2011) Felix Heymann et al.   HEPATOLOGY

Human macrophages primed with angiogenic factors show dynamic plasticity, irrespective of extracellular matrix components

(2011) Diana T.A. Ploeger et al.   IMMUNOBIOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Airway Wall Stiffening Increases Peak Wall Shear Stress: A Fluid–Structure Interaction Study in Rigid and Compliant Airways

(2010) Guohua Xia et al.   ANNALS OF BIOMEDICAL ENGINEERING

Fibulin-1 Is Increased in Asthma – A Novel Mediator of Airway Remodeling?

(2010) Justine Y. Lau et al.   PLoS One

PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity

(2009) Stephanie Nemir et al.   BIOTECHNOLOGY AND BIOENGINEERING

Accumulation of fibronectin in the heart after myocardial infarction: a putative stimulator of adhesion and proliferation of adipose-derived stem cells

(2008) A. van Dijk et al.   CELL AND TISSUE RESEARCH

Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds  5 1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study

(2008) A. D. Ricart et al.   CLINICAL CANCER RESEARCH

Modulus-dependent macrophage adhesion and behavior

(2008) E. F. Irwin et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia/Reperfusion Injury

(2008) Wilco P. Pulskens et al.   PLoS One

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY