Succinate receptor mediates intestinal inflammation and fibrosis

LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice

(2018) Cong Thuc Le et al.   PLoS One

Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases

(2017) Florian Rieder et al.   GASTROENTEROLOGY

Thermodynamic Aspects and Reprogramming Cellular Energy Metabolism during the Fibrosis Process

(2017) Alexandre Vallée et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutaminolysis is required for transforming growth factor-β1–induced myofibroblast differentiation and activation

(2017) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OP007 A multi-centre double blind randomised placebo-controlled study of the use of rectal tacrolimus in the treatment of resistant ulcerative proctitis

(2017) I.C. Lawrance et al.   Journal of Crohns & Colitis

Meta-Analysis of Fecal Microbiota and Metabolites in Experimental Colitic Mice during the Inflammatory and Healing Phases

(2017) Toshifumi Osaka et al.   Nutrients

Decreased Fibrogenesis After Treatment with Pirfenidone in a Newly Developed Mouse Model of Intestinal Fibrosis

(2016) Remo Meier et al.   INFLAMMATORY BOWEL DISEASES

Anti-MMP-9 Antibody

(2016) Laurence Goffin et al.   INFLAMMATORY BOWEL DISEASES

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Insight into SUCNR1 (GPR91) structure and function

(2016) Julie Gilissen et al.   PHARMACOLOGY & THERAPEUTICS

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells

(2015) Ying Hui Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD

(2015) J Cosín-Roger et al.   Mucosal Immunology

Prognosis Biomarkers of Severe Sepsis and Septic Shock by 1H NMR Urine Metabolomics in the Intensive Care Unit

(2015) Monica Garcia-Simon et al.   PLoS One

Targeted Disruption of theSUCNR1Metabolic Receptor Leads to Dichotomous Effects on Obesity

(2014) Kenneth J. McCreath et al.   DIABETES

Mechanisms That Mediate the Development of Fibrosis in Patients With Crohnʼs Disease

(2014) Chao Li et al.   INFLAMMATORY BOWEL DISEASES

Crohn's disease complicated by strictures: a systematic review

(2013) Florian Rieder et al.   GUT

Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD

(2013) D Ortiz-Masiá et al.   Mucosal Immunology

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

M2 Macrophages Activate WNT Signaling Pathway in Epithelial Cells: Relevance in Ulcerative Colitis

(2013) Jesús Cosín-Roger et al.   PLoS One

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease

(2012) Florian Rieder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Metabolomic Profile of Human Myocardial Ischemia by Nuclear Magnetic Resonance Spectroscopy of Peripheral Blood Serum

(2012) Vicente Bodi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Induction of CD36 and Thrombospondin-1 in Macrophages by Hypoxia-Inducible Factor 1 and Its Relevance in the Inflammatory Process

(2012) Dolores Ortiz-Masià et al.   PLoS One

The Succinate Receptor as a Novel Therapeutic Target for Oxidative and Metabolic Stress-Related Conditions

(2012) Ana Carolina Ariza et al.   Frontiers in Endocrinology

GCMS-based metabolomic study in mice with colitis induced by dextran sulfate sodium

(2011) Yuuki Shiomi et al.   INFLAMMATORY BOWEL DISEASES

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY

Metabolite profiling of fecal water extracts from human colorectal cancer

(2008) Daniel Monleón et al.   NMR IN BIOMEDICINE