Can Polyphenols Inhibit Ferroptosis?

Carthamin yellow improves cerebral ischemia‑reperfusion injury by attenuating inflammation and ferroptosis in rats

(2021) Huihui Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Comparison of Ferroptosis-Inhibitory Mechanisms between Ferrostatin-1 and Dietary Stilbenes (Piceatannol and Astringin)

(2021) Ban Chen et al.   MOLECULES

Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

The Protective Effect of Cyanidin-3-Glucoside on Myocardial Ischemia-Reperfusion Injury through Ferroptosis

(2021) Xin Shan et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis‐Inhibitory Effect and Possible Mechanisms of Ellagitannin Geraniin

(2021) Ban Chen et al.   ChemistryOpen

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?

(2021) Eva F. DeRango-Adem et al.   Frontiers in Pharmacology

Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis

(2021) Zhenyu Fan et al.   Frontiers in Pharmacology

Discovery of phloroglucinols from Hypericum japonicum as ferroptosis inhibitors

(2021) Xing Peng et al.   FITOTERAPIA

Ferroptosis-Inhibitory Difference between Chebulagic Acid and Chebulinic Acid Indicates Beneficial Role of HHDP

(2021) Lin Yang et al.   MOLECULES

Ferroptosis: the potential value target in atherosclerosis

(2021) Siyu Ouyang et al.   Cell Death & Disease

Icariin inhibits hypoxia/reoxygenation‐induced ferroptosis of cardiomyocytes via regulation of the Nrf2/HO‐1 signaling pathway

(2021) Xiu‐Juan Liu et al.   FEBS Open Bio

Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis

(2021) Yuan Yuan et al.   Biomolecules

Nephroprotective Role of Chrysophanol in Hypoxia/Reoxygenation-Induced Renal Cell Damage via Apoptosis, ER Stress, and Ferroptosis

(2021) Chih-Hung Lin et al.   Biomedicines

Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

(2021) Yi Yu et al.   Cell Death Discovery

Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis

(2021) Ting Li et al.   GENE

Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis

(2021) Shujun Xu et al.   Bioengineered

Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy

(2021) Huan He et al.   Redox Biology

Gossypol Acetic Acid Attenuates Cardiac Ischemia/Reperfusion Injury in Rats via an Antiferroptotic Mechanism

(2021) Jian-Hong Lin et al.   Biomolecules

Gastrodin Inhibits H2O2-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6

(2020) Ting Jiang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved!

(2020) Massimo M. Santoro   Cell Metabolism

Simultaneous Study of Anti-Ferroptosis and Antioxidant Mechanisms of Butein and (S)-Butin

(2020) Liu et al.   MOLECULES

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Inhibitory Effect and Mechanism of Action of Quercetin and Quercetin Diels-Alder anti-Dimer on Erastin-Induced Ferroptosis in Bone Marrow-Derived Mesenchymal Stem Cells

(2020) Xican Li et al.   Antioxidants

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis inhibitory constituents from the fruits of Cullen corylifolium

(2020) Aftab Yaseen et al.   NATURAL PRODUCT RESEARCH

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

(2020) Xiaohua Song et al.   Frontiers in Neuroscience

Identification of two novel prenylated flavonoids in mulberry leaf and their bioactivities

(2020) Lingrong Wen et al.   FOOD CHEMISTRY

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell

(2020) Tao Bai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quercetin alleviates acute kidney injury by inhibiting ferroptosis

(2020) Yue Wang et al.   Journal of Advanced Research

Challenges and Opportunities of Deferoxamine Delivery for Treatment of Alzheimer’s Disease, Parkinson’s Disease, and Intracerebral Hemorrhage

(2020) Amy Corbin Farr et al.   MOLECULAR PHARMACEUTICS

Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes

(2020) Dan Li et al.   Nutrients

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11/GPX4 axis in gerbils

(2020) Xue Guan et al.   LIFE SCIENCES

Icariin enhances cell survival in lipopolysaccharide‑induced synoviocytes by suppressing ferroptosis via the Xc‑/GPX4 axis

(2020) Huasong Luo et al.   Experimental and Therapeutic Medicine

Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway

(2020) Jie Cheng et al.   LIFE SCIENCES

Bioactivity of dietary polyphenols: The role of metabolites

(2019) Simon Vlad Luca et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death

(2019) Melania Guerrero-Hue et al.   FASEB JOURNAL

Sulfasalazine‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor

(2019) Haochen Yu et al.   ONCOLOGY REPORTS

Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis

(2019) Qin Li et al.   Frontiers in Pharmacology

Polyphenols in human nutrition: from the in vitro antioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability – an overview and perspective

(2019) T. Ruskovska et al.   BRITISH JOURNAL OF NUTRITION

Neuroprotective effects of Brazilian green propolis on oxytosis/ferroptosis in mouse hippocampal HT22 cells

(2019) Madoka Takashima et al.   FOOD AND CHEMICAL TOXICOLOGY

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

(2019) Wijdan M. Dabeek et al.   Nutrients

Iron homeostasis and oxidative stress: An intimate relationship

(2019) Dimitrios Galaris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Polyphenols: Modulators of Platelet Function and Platelet Microparticle Generation?

(2019) Borkwei Ed Nignpense et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis

(2018) Bei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Polyphenols and Bioavailability: an update

(2018) Hui Teng et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The tumor suppressor protein p53 and the ferroptosis network

(2018) Rui Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis

(2018) Yuki Yamaguchi et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Antioxidant and anti-inflammatory activities of quercetin and its derivatives

(2018) Marija Lesjak et al.   Journal of Functional Foods

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

(2018) Jipeng Guo et al.   Cancer Research and Treatment

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

The Role of Ferroptosis in Cancer Development and Treatment Response

(2018) Bin Lu et al.   Frontiers in Pharmacology

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Unconventional Ways to Live and Die: Cell Death and Survival in Development, Homeostasis, and Disease

(2018) Swapna A. Gudipaty et al.   Annual Review of Cell and Developmental Biology

Wild edible onions — Allium flavum and Allium carinatum — successfully prevent adverse effects of chemotherapeutic drug doxorubicin

(2018) Pavić Aleksandar et al.   BIOMEDICINE & PHARMACOTHERAPY

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury

(2018) Elizabeth M. Kenny et al.   CRITICAL CARE MEDICINE

To the edge of cell death and back

(2018) Yi-Nan Gong et al.   FEBS Journal

A review on iron chelators as potential therapeutic agents for the treatment of Alzheimer’s and Parkinson’s diseases

(2018) Yash Pal Singh et al.   MOLECULAR DIVERSITY

Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa

(2018) Wolfgang Fischer et al.   Redox Biology

Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma

(2017) Weijun Ou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polyphenols and their benefits: A review

(2017) Hassan Rasouli et al.   INTERNATIONAL JOURNAL OF FOOD PROPERTIES

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

(2017) Samantha W. Alvarez et al.   NATURE

Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells

(2017) Shihui Hao et al.   NEOPLASIA

Identification of baicalein as a ferroptosis inhibitor by natural product library screening

(2016) Yangchun Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The flavonoid fisetin as an anticancer agent targeting the growth signaling pathways

(2016) Thamaraiselvan Rengarajan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Non-covalent interaction between dietary stilbenoids and human serum albumin: Structure–affinity relationship, and its influence on the stability, free radical scavenging activity and cell uptake of stilbenoids

(2016) Hui Cao et al.   FOOD CHEMISTRY

Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate

(2016) Anna L. Greenshields et al.   MOLECULAR CARCINOGENESIS

Antibiofilm Activity of Plant Polyphenols

(2016) Lívia Slobodníková et al.   MOLECULES

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

(2016) Tarique Hussain et al.   Oxidative Medicine and Cellular Longevity

Anticancer Efficacy of Polyphenols and Their Combinations

(2016) Aleksandra Niedzwiecki et al.   Nutrients

Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

(2016) Tina Sehm et al.   Oncotarget

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

(2015) Christophe Louandre et al.   CANCER LETTERS

Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses

(2015) Le Jiang et al.   CELL CYCLE

Bioactivity of phenolic acids: Metabolites versus parent compounds: A review

(2015) Sandrina A. Heleno et al.   FOOD CHEMISTRY

Recent developments in curcumin and curcumin based polymeric materials for biomedical applications: A review

(2015) Kashif Mahmood et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Properties of Resveratrol:In VitroandIn VivoStudies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans

(2015) J. Gambini et al.   Oxidative Medicine and Cellular Longevity

Effect of Allium flavum L. and Allium melanantherum Panč. Extracts on Oxidative DNA Damage and Antioxidative Enzymes Superoxide Dismutase and Catalase

(2015) Dragana Mitić-Ćulafić et al.   PLANT FOODS FOR HUMAN NUTRITION

The role of lipoxygenases in pathophysiology; new insights and future perspectives

(2015) Ryuichi Mashima et al.   Redox Biology

Advances in the biotechnological glycosylation of valuable flavonoids

(2014) Jianbo Xiao et al.   BIOTECHNOLOGY ADVANCES

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease

(2014) Maurice W. Dysken et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study

(2014) Giuseppe Grosso et al.   NUTRITION

Resources and Biological Activities of Natural Polyphenols

(2014) An-Na Li et al.   Nutrients

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

(2013) Orly Weinreb et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intakes of total and individual flavonoids by US adults

(2013) Wei Bai et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Phenolic profile, antioxidant, anti-inflammatory and cytotoxic activities of small yellow onion (Allium flavum L. subsp. flavum, Alliaceae)

(2013) Natasa Simin et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Plant phenolics: Recent advances on their biosynthesis, genetics, and ecophysiology

(2013) Véronique Cheynier et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Metabolic and colonic microbiota transformation may enhance the bioactivities of dietary polyphenols

(2013) Yi-Shiou Chiou et al.   Journal of Functional Foods

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement

(2013) Surangi Thilakarathna et al.   Nutrients

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Pharmacokinetics of Quercetin Absorption from Apples and Onions in Healthy Humans

(2012) Jihyun Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

(2011) Richard J Bridges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Many stimuli pull the necrotic trigger, an overview

(2011) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Polyphenols as antimicrobial agents

(2011) Maria Daglia   CURRENT OPINION IN BIOTECHNOLOGY

The Role of Dietary Fiber in the Bioaccessibility and Bioavailability of Fruit and Vegetable Antioxidants

(2011) Hugo Palafox-Carlos et al.   JOURNAL OF FOOD SCIENCE

What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol

(2011) Ole Vang et al.   PLoS One

Bioavailability of the Polyphenols: Status and Controversies

(2010) Massimo D’Archivio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liquid chromatography/tandem mass spectrometry study of anti-inflammatory activity of Plantain (Plantago L.) species

(2010) Ivana N. Beara et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Estimation of Dietary Sources and Flavonoid Intake in a Spanish Adult Population (EPIC-Spain)

(2010) Raul Zamora-Ros et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages

(2008) Tzi-Wei Lian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Dietary Flavonoid Sources in Australian Adults

(2008) Shawn M. Somerset et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice

(2007) ZhongMao Guo et al.   FREE RADICAL BIOLOGY AND MEDICINE