Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ferroptosis and its emerging roles in cardiovascular diseases

(2021) Ning Li et al.   PHARMACOLOGICAL RESEARCH

Regulated cell death pathways in doxorubicin-induced cardiotoxicity

(2021) Effimia Christidi et al.   Cell Death & Disease

Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1

(2020) Peng Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capsaicin Alleviates the Deteriorative Mitochondrial Function by Upregulating 14-3-3η in Anoxic or Anoxic/Reoxygenated Cardiomyocytes

(2020) Yang Qiao et al.   Oxidative Medicine and Cellular Longevity

Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway

(2020) Huan He et al.   Frontiers in Pharmacology

Kaempferol protects mitochondria and alleviates damages against endotheliotoxicity induced by doxorubicin

(2020) Weiqi Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Epigallocatechin‐3‐gallate activates the AMP‐activated protein kinase signaling pathway to reduce lipid accumulation in canine hepatocytes

(2020) Hongyan Ding et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitophagy inhibitor liensinine suppresses doxorubicin-induced cardiotoxicity through inhibition of Drp1-mediated maladaptive mitochondrial fission

(2020) Xinyue Liang et al.   PHARMACOLOGICAL RESEARCH

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

(2020) Tomonori Tadokoro et al.   JCI Insight

Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity

(2020) Wanjun Ma et al.   Frontiers in Cell and Developmental Biology

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis

(2020) Zhen Cai et al.   MOLECULAR CELL

Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition

(2020) Yunchang Liu et al.   Cell Death & Disease

NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway

(2020) Pengfei Liu et al.   Redox Biology

Green tea derivative (−)-epigallocatechin-3-gallate (EGCG) confers protection against ionizing radiation-induced intestinal epithelial cell death both in vitro and in vivo

(2020) Li-Wei Xie et al.   FREE RADICAL BIOLOGY AND MEDICINE

Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression

(2020) Panxia Wang et al.   Acta Pharmaceutica Sinica B

Recent Advances in the Understanding of the Health Benefits and Molecular Mechanisms Associated with Green Tea Polyphenols

(2019) Lujuan Xing et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Quercetin protects cardiomyocytes against doxorubicin-induced toxicity by suppressing oxidative stress and improving mitochondrial function via 14-3-3γ

(2019) Xuanying Chen et al.   TOXICOLOGY MECHANISMS AND METHODS

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigallocatechin Gallate Inhibits Hepatic Glucose Production in Primary Hepatocytes via Downregulating PKA Signaling Pathways and Transcriptional Factor FoxO1

(2019) Xiaopeng Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

(2019) Yue Zong et al.   CELL RESEARCH

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Oxidized phospholipids in Doxorubicin-induced cardiotoxicity

(2019) Navid Koleini et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cancer treatment and survivorship statistics, 2019

(2019) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells

(2019) Zili Zhang et al.   Autophagy

An update on the mechanisms related to cell death and toxicity of doxorubicin and the protective role of nutrients

(2019) Alfonso Varela-López et al.   FOOD AND CHEMICAL TOXICOLOGY

Tetramethylpyrazine Attenuates the Endotheliotoxicity and the Mitochondrial Dysfunction by Doxorubicin via 14-3-3γ/Bcl-2

(2019) Bin Yang et al.   Oxidative Medicine and Cellular Longevity

Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway

(2019) Yan-Zhao Wu et al.   Oxidative Medicine and Cellular Longevity

Autophagy in Human Health and Disease: Novel Therapeutic Opportunities

(2018) Francesca Giampieri et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Structural Modification of (−)-Epigallocatechin Gallate (EGCG) Shows Significant Enhancement in Mitochondrial Biogenesis

(2018) Taewoong Ha et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases

(2018) Qian Yi Eng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Epigallocatechin-3-Gallate (EGCG) Promotes Autophagy-Dependent Survival via Influencing the Balance of mTOR-AMPK Pathways upon Endoplasmic Reticulum Stress

(2018) Marianna Holczer et al.   Oxidative Medicine and Cellular Longevity

Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans

(2018) Li-Gui Xiong et al.   Redox Biology

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

(2018) Elaine C. Thomas et al.   BIOCHEMICAL JOURNAL

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

(2018) D.A. Stoyanovsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis

(2018) Dong Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Knockdown of lncRNA AK139328 alleviates myocardial ischaemia/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy

(2018) Si-yang Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Epigallocatechin-3-gallate protects against 1,3-dichloro-2-propanol-induced lipid accumulation in C57BL/6J mice

(2018) Jing Lu et al.   LIFE SCIENCES

Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3γ

(2018) Huan He et al.   Food & Function

Green tea extract modulates oxidative tissue injury in beta-thalassemic mice by chelation of redox iron and inhibition of lipid peroxidation

(2018) Pimpisid Koonyosying et al.   BIOMEDICINE & PHARMACOTHERAPY

EGCG Reduces Obesity and White Adipose Tissue Gain Partly Through AMPK Activation in Mice

(2018) Fang Li et al.   Frontiers in Pharmacology

Metal chelator EGCG attenuates Fe(III)-induced conformational transition of α-synuclein and protects AS-PC12 cells against Fe(III)-induced death

(2017) Juan Zhao et al.   JOURNAL OF NEUROCHEMISTRY

Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart

(2017) Eduard Jirkovský et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

(−)-Epigallocatechin-3-gallate alleviates doxorubicin-induced cardiotoxicity in sarcoma 180 tumor-bearing mice

(2017) Yu-Fei Yao et al.   LIFE SCIENCES

Potential Biological Effects of (-)-Epigallocatechin-3-gallate on the Treatment of Nonalcoholic Fatty Liver Disease

(2017) Cheng Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

MitoTEMPO Prevents Oxalate Induced Injury in NRK-52E Cells via Inhibiting Mitochondrial Dysfunction and Modulating Oxidative Stress

(2017) Jiaqiao Zhang et al.   Oxidative Medicine and Cellular Longevity

RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems

(2017) Daiha Shin et al.   Redox Biology

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome AcidificationCLINICAL PERSPECTIVE

(2016) Dan L. Li et al.   CIRCULATION

The Global Burden of Cancer 2013

(2015) Christina Fitzmaurice et al.   JAMA Oncology

Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both Topoisomerase II isoforms

(2014) Shiwei Deng et al.   BMC CANCER

Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity

(2014) Debariya Dutta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigallocatechin Gallate (EGCG) Stimulates Autophagy in Vascular Endothelial Cells

(2013) Hae-Suk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes

(2012) Tomonori Kawaguchi et al.   CARDIOVASCULAR RESEARCH

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Berberine Inhibits Doxorubicin-Triggered Cardiomyocyte Apoptosis via Attenuating Mitochondrial Dysfunction and Increasing Bcl-2 Expression

(2012) Xiuxiu Lv et al.   PLoS One

A Major Green Tea Component, (−)-Epigallocatechin-3-gallate, Ameliorates Doxorubicin-Mediated Cardiotoxicity in Cardiomyocytes of Neonatal Rats

(2010) Wenjuan Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anthracycline Cardiotoxicity: From Bench to Bedside

(2008) Luca Gianni et al.   JOURNAL OF CLINICAL ONCOLOGY