Chemokines in the Landscape of Cancer Immunotherapy: How They and Their Receptors Can Be Used to Turn Cold Tumors into Hot Ones?

Cardiovascular Toxicity of Immune Checkpoint Inhibitors: Clinical Risk Factors

(2021) Flora Pirozzi et al.   Current Oncology Reports

Research Trends and Regulation of CCL5 in Prostate Cancer

(2021) Renlun Huang et al.   OncoTargets and Therapy

A Prognostic Signature Based on Immunogenomic Profiling Offers Guidance for Esophageal Squamous Cell Cancer Treatment

(2021) Jianyao Gao et al.   Frontiers in Oncology

The efficacy of PD-1/PD-L1 blockade in cold cancers and future perspectives

(2021) Jamal Majidpoor et al.   CLINICAL IMMUNOLOGY

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

(2021) Dominik Pfister et al.   NATURE

CXCR1 correlates to poor outcomes of EGFR-TKI against advanced non-small cell lung cancer by activating chemokine and JAK/STAT pathway

(2021) Fang Yang et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Recruitment and Expansion of Tregs Cells in the Tumor Environment—How to Target Them?

(2021) Justine Cinier et al.   Cancers

Association of Immune Related Adverse Events With Efficacy of Immune Checkpoint Inhibitors and Overall Survival in Cancers: A Systemic Review and Meta-analysis

(2021) Yong Fan et al.   Frontiers in Oncology

A randomized, placebo-controlled phase 2 study of paclitaxel in combination with reparixin compared to paclitaxel alone as front-line therapy for metastatic triple-negative breast cancer (fRida)

(2021) Lori J. Goldstein et al.   BREAST CANCER RESEARCH AND TREATMENT

Identification of immune cell infiltration pattern and related critical genes in metastatic castration-resistant prostate cancer by bioinformatics analysis

(2021) Caibin Fan et al.   Cancer Biomarkers

Eradicating micrometastases with immune checkpoint blockade: Strike while the iron is hot

(2021) Yelena Y. Janjigian et al.   CANCER CELL

Tumor-infiltrating CD8+ T cells recognize a heterogeneously expressed functional neoantigen in clear cell renal cell carcinoma

(2021) Masahiro Matsuki et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

(2021) Maosen Xu et al.   CELL PROLIFERATION

CXCL8 Facilitates the Survival and Paclitaxel-Resistance of Triple-Negative Breast Cancers

(2021) Maolin Yi et al.   Clinical Breast Cancer

Chemokine-Directed Tumor Microenvironment Modulation in Cancer Immunotherapy

(2021) Pedro Bule et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Establishment and characterization of patient-derived head and neck cancer models from surgical specimens and endoscopic biopsies

(2021) Daniel Strüder et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

An updated review on the role of the CXCL8-CXCR1/2 axis in the progression and metastasis of breast cancer

(2021) Amaresh Mishra et al.   MOLECULAR BIOLOGY REPORTS

Modulation of CXCR1 and CXCR3 expression on NK cells via Tim-3 in a murine model of primary biliary cholangitis

(2021) Jiamin Xu et al.   MOLECULAR IMMUNOLOGY

CXCL9 Is a Potential Biomarker of Immune Infiltration Associated With Favorable Prognosis in ER-Negative Breast Cancer

(2021) Yuan-ke Liang et al.   Frontiers in Oncology

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy

(2021) Marie Siwicki et al.   Science Immunology

Identification of the Immune-Related Genes in Tumor Microenvironment That Associated With the Recurrence of Head and Neck Squamous Cell Carcinoma

(2021) Liu Chengcheng et al.   Frontiers in Cell and Developmental Biology

Turning ‘Cold’ tumors ‘Hot’: immunotherapies in sarcoma

(2021) Jeff Rytlewski et al.   Annals of Translational Medicine

Immune activation and evolution through chemotherapy plus checkpoint blockade in triple-negative breast cancer

(2021) Siang-Boon Koh et al.   CANCER CELL

Hallmarks of response, resistance, and toxicity to immune checkpoint blockade

(2021) Golnaz Morad et al.   CELL

Time to dissect the autoimmune etiology of cancer antibody immunotherapy

(2020) Michael Dougan et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor

(2020) Carl-Mikael Suomivuori et al.   SCIENCE

CCR8 blockade primes anti-tumor immunity through intratumoral regulatory T cells destabilization in muscle-invasive bladder cancer

(2020) Tao Wang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CCL2/CCR2 signaling in cancer pathogenesis

(2020) Qiongyu Hao et al.   Cell Communication and Signaling

The identification of highly upregulated genes in claudin-low breast cancer through an integrative bioinformatics approach

(2020) Hatem Zayed   COMPUTERS IN BIOLOGY AND MEDICINE

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

(2020) Álvaro Teijeira et al.   IMMUNITY

CCL3–CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways

(2020) Takayuki Kodama et al.   LABORATORY INVESTIGATION

Learning from clinical trials of neoadjuvant checkpoint blockade

(2020) Judith M. Versluis et al.   NATURE MEDICINE

TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

(2020) Andrew J. Gunderson et al.   Nature Communications

Database Mining of Genes of Prognostic Value for the Prostate Adenocarcinoma Microenvironment Using the Cancer Gene Atlas

(2020) Xin Zhao et al.   Biomed Research International

Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges

(2020) Krishna Rajarathnam et al.   Frontiers in Immunology

The Chemokine Receptor CCR7 Uses Distinct Signaling Modules With Biased Functionality to Regulate Dendritic Cells

(2020) José Luis Rodríguez-Fernández et al.   Frontiers in Immunology

CXCR3 Ligands in Cancer and Autoimmunity, Chemoattraction of Effector T Cells, and Beyond

(2020) Nathan Karin   Frontiers in Immunology

CCL2 Expression in Tumor Cells and Tumor-Infiltrating Immune Cells Shows Divergent Prognostic Potential for Bladder Cancer Patients Depending on Lymph Node Stage

(2020) Markus Eckstein et al.   Cancers

Clinical Challenges of Immune Checkpoint Inhibitors

(2020) Maria de Miguel et al.   CANCER CELL

CCR5-Mediated Signaling is Involved in Invasion of Glioblastoma Cells in Its Microenvironment

(2020) Metka Novak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer cell CCR2 orchestrates suppression of the adaptive immune response

(2020) Miriam R. Fein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A new clinical prognostic nomogram for liver cancer based on immune score

(2020) Qinyan Shen et al.   PLoS One

Next-generation humanized patient-derived xenograft mouse model for pre-clinical antibody studies in neuroblastoma

(2020) Rosa Nguyen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

(2020) Daniel K. Wells et al.   CELL

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

(2020) Patrick A. Ott et al.   CELL

Breast cancer cells promote self-migration by secreting interleukin 8 to induce NET formation

(2020) Zeyu Cai et al.   GENE

The Development and Homing of Myeloid-Derived Suppressor Cells: From a Two-Stage Model to a Multistep Narrative

(2020) Nathan Karin   Frontiers in Immunology

Transcriptional Expressions of CXCL9/10/12/13 as Prognosis Factors in Breast Cancer

(2020) Yan Li et al.   Journal of Oncology

C-C motif chemokine ligand 5 and C-C chemokine receptor type 5: possible diagnostic application in breast cancer patients

(2020) Emilia Dąbrowska et al.   ACTA BIOCHIMICA POLONICA

Identification of prognosis-related genes in the cervical cancer immune microenvironment

(2020) Lirong Yang et al.   GENE

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

(2020) Erez N. Baruch et al.   SCIENCE

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies

(2019) Yuanbin Song et al.   Nature Communications

Turning “Cold” Into “Hot” Tumors—Opportunities and Challenges for Radio-Immunotherapy Against Primary and Metastatic Brain Cancers

(2019) Lisa Sevenich   Frontiers in Oncology

Neoantigen-directed immune escape in lung cancer evolution

(2019) Rachel Rosenthal et al.   NATURE

Chemokine Receptor Redundancy and Specificity Are Context Dependent

(2019) Douglas P. Dyer et al.   IMMUNITY

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

(2019) Melvyn T. Chow et al.   IMMUNITY

CCR5 is Associated With Immune Cell Infiltration and Prognosis of Lung Cancer

(2019) Jia Zhang et al.   Journal of Thoracic Oncology

Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

(2019) Denarda Dangaj et al.   CANCER CELL

Recent Advances targeting CCR5 for Cancer and its Role in Immuno-Oncology

(2019) Xuanmao Jiao et al.   CANCER RESEARCH

CCR4 Blockade Depletes Regulatory T Cells and Prolongs Survival in a Canine Model of Bladder Cancer

(2019) Shingo Maeda et al.   Cancer Immunology Research

Biased S1PR1 Signaling in B Cells Subverts Responses to Homeostatic Chemokines, Severely Disorganizing Lymphoid Organ Architecture

(2019) Il-Young Hwang et al.   JOURNAL OF IMMUNOLOGY

Increased infiltration of CCR4‐positive regulatory T cells in prostate cancer tissue is associated with a poor prognosis

(2019) Masahito Watanabe et al.   PROSTATE

Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis

(2019) Hila Doron et al.   Cell Reports

Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

(2019) Astrid S. Jørgensen et al.   Frontiers in Immunology

When Cold Is Hot: Immune Checkpoint Inhibition Therapy for Rhabdoid Tumors

(2019) Mark Yarmarkovich et al.   CANCER CELL

One or Two Immune Checkpoint Inhibitors?

(2019) Caroline Robert et al.   CANCER CELL

CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

(2018) Chenlu Zhang et al.   BMC CANCER

Targeting CCR8 induces protective antitumor immunity and enhances vaccine-induced responses in colon cancer

(2018) Daniel O Villarreal et al.   CANCER RESEARCH

Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand–Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib

(2018) Mitsukuni Suenaga et al.   Clinical Colorectal Cancer

CXCR1/2 Chemokine Network Regulates Melanoma Resistance to Chemotherapies Mediated by NF-κB

(2018) S. Wu et al.   CURRENT MOLECULAR MEDICINE

Chemokines and cancer: new immune checkpoints for cancer therapy

(2018) Nathan Karin   CURRENT OPINION IN IMMUNOLOGY

High expression of CC chemokine receptor 5 (CCR5) promotes disease progression in patients with B-cell non-Hodgkin lymphomas

(2018) Aleksandra Butrym et al.   CURRENT PROBLEMS IN CANCER

Biased signaling of G protein-coupled receptors – From a chemokine receptor CCR7 perspective

(2018) Astrid Sissel Jørgensen et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies

(2018) Shetal A. Patel et al.   IMMUNITY

Blockade of CCR5-mediated myeloid derived suppressor cell accumulation enhances anti-PD1 efficacy in gastric cancer

(2018) Liu Yang et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Early B cell changes predict autoimmunity following combination immune checkpoint blockade

(2018) Rituparna Das et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Mechanisms of Biased and Probe-Dependent Signaling at CXC-Motif Chemokine Receptor CXCR3 Induced by Negative Allosteric Modulators

(2018) Regine Brox et al.   MOLECULAR PHARMACOLOGY

Safety of combining radiotherapy with immune-checkpoint inhibition

(2018) William L. Hwang et al.   Nature Reviews Clinical Oncology

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Warming “Cold” Melanoma with TLR9 Agonists

(2018)   Cancer Discovery

High levels of CCL2 or CCL4 in the tumor microenvironment predict unfavorable survival in lung adenocarcinoma

(2018) Lei Li et al.   Thoracic Cancer

Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy

(2018) Aurélie Durgeau et al.   Frontiers in Immunology

Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands

(2018) Mieke Metzemaekers et al.   Frontiers in Immunology

Prognosis of ovarian cancer is associated with effector memory CD8+ T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells

(2018) Sonja Lieber et al.   OncoImmunology

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

(2018) Livnat Jerby-Arnon et al.   CELL

Role of CCL5 and CCR5 gene polymorphisms in epidermal growth factor receptor signalling blockade in metastatic colorectal cancer: analysis of the FIRE-3 trial

(2018) Mitsukuni Suenaga et al.   EUROPEAN JOURNAL OF CANCER

CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer

(2018) Lei Wang et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

A small-molecule antagonist of CXCR1 and CXCR2 inhibits cell proliferation, migration and invasion in melanoma via PI3K/AKT pathway

(2018) Fu-min Shang et al.   MEDICINA CLINICA

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

(2018) Derin B. Keskin et al.   NATURE

The relationship between chemokines CCL2, CCL3, and CCL4 with the tumor microenvironment and tumor-associated macrophage markers in colorectal cancer

(2018) Marjorie De la Fuente López et al.   TUMOR BIOLOGY

High expression of CCL2 in tumor cells and abundant infiltration with CD14 positive macrophages predict early relapse in breast cancer

(2018) Marja Heiskala et al.   VIRCHOWS ARCHIV

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

(2017) Chiara Berlato et al.   JOURNAL OF CLINICAL INVESTIGATION

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

(2017) Vikram R. Juneja et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment

(2017) Bradley W. Blaser et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR3/CXCL10 Axis Shapes Tissue Distribution of Memory Phenotype CD8+T Cells in Nonimmunized Mice

(2017) Cécile Alanio et al.   JOURNAL OF IMMUNOLOGY

A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

(2017) Marta Łuksza et al.   NATURE

CCL2 expression correlates with Snail expression and affects the prognosis of patients with gastric cancer

(2017) Jia Zhang et al.   PATHOLOGY RESEARCH AND PRACTICE

CCR8+FOXp3+Tregcells as master drivers of immune regulation

(2017) Yiftah Barsheshet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells

(2017) M. Fehlings et al.   Nature Communications

Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment

(2017) Daria Marley Kemp et al.   Oncotarget

Single-cell genomic analysis of head and neck squamous cell carcinoma

(2017) Andres Stucky et al.   Oncotarget

CCR5 Directs the Mobilization of CD11b + Gr1 + Ly6C low Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development

(2017) Elias Hawila et al.   Cell Reports

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

CCR5-Δ32 Polymorphism and Susceptibility to Cervical Cancer: Association With Early Stage of Cervical Cancer

(2017) Hariom Singh et al.   ONCOLOGY RESEARCH

Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy

(2017) Weiqiang Zhou et al.   CURRENT MEDICINAL CHEMISTRY

A novel prognostic model for osteosarcoma using circulating CXCL10 and FLT3LG

(2016) Ricardo J. Flores et al.   CANCER

Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients

(2016) Niels Halama et al.   CANCER CELL

The CXCL8-CXCR1/2 pathways in cancer

(2016) Qian Liu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

(2016) George Plitas et al.   IMMUNITY

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

(2016) Jonathan M. Pitt et al.   IMMUNITY

Repertaxin, an inhibitor of the chemokine receptors CXCR1 and CXCR2, inhibits malignant behavior of human gastric cancer MKN45 cells in vitro and in vivo and enhances efficacy of 5-fluorouracil

(2016) JUNPU WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CXCR1 promotes malignant behavior of gastric cancer cells in vitro and in vivo in AKT and EKR1/2 phosphorylation

(2016) JUNPU WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Antitumor Effect of IP-10 by Using Two Different Approaches: Live Delivery System and Gene Therapy

(2016) Yasaman Taslimi et al.   Journal of Breast Cancer

Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes

(2016) M. A. Hauser et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

Monokine induced by interferon gamma (MIG/CXCL9) is an independent prognostic factor in newly diagnosed myeloma

(2016) Arnold Bolomsky et al.   LEUKEMIA & LYMPHOMA

Blocking the CCL2–CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model

(2016) Kun-Yu Teng et al.   MOLECULAR CANCER THERAPEUTICS

Exploiting agonist biased signaling of chemokines to target cancer

(2016) Ishan Roy et al.   MOLECULAR CARCINOGENESIS

Neoantigen landscape dynamics during human melanoma–T cell interactions

(2016) Els M. E. Verdegaal et al.   NATURE

Thy1+IL-7+lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation

(2016) Kenta Shinoda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blocking PI3K  makes cold tumors hot

(2016) K. L. Mueller   SCIENCE

CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival

(2016) Muthulekha Swamydas et al.   Science Translational Medicine

High expression of chemokine CCL2 is associated with recurrence after surgery in clear-cell renal cell carcinoma

(2016) Yuanfeng Yang et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Whole transcriptome profiling of patient-derived xenograft models as a tool to identify both tumor and stromal specific biomarkers

(2016) James R. Bradford et al.   Oncotarget

Patient-derived xenograft models of colorectal cancer in pre-clinical research: a systematic review

(2016) Kai M. Brown et al.   Oncotarget

Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22–CCR4 axis

(2016) Aerken Maolake et al.   Oncotarget

Targeting the CCL2-CCR2 signaling axis in cancer metastasis

(2016) Su Yin Lim et al.   Oncotarget

Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset

(2016) Mickaël J. Ploquin et al.   PLoS Pathogens

CCL2 as a potential therapeutic target for clear cell renal cell carcinoma

(2016) Ryuichiro Arakaki et al.   Cancer Medicine

Critical roles of chemokine receptor CCR5 in regulating glioblastoma proliferation and invasion

(2015) Lanfu Zhao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling

(2015) I. Roy et al.   CANCER RESEARCH

Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages

(2015) C. Frankenberger et al.   CANCER RESEARCH

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

(2015) Sonja Kleffel et al.   CELL

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients

(2015) K. Kurose et al.   CLINICAL CANCER RESEARCH

CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice

(2015) Yunching Chen et al.   HEPATOLOGY

Biased Signaling at Chemokine Receptors

(2015) Jenny Corbisier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages

(2015) Takanori Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets

(2015) Nathan Karin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

(2015) Dongjun Peng et al.   NATURE

Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy

(2015) Rosa Barreira da Silva et al.   NATURE IMMUNOLOGY

Anti–PD-1–Related Pneumonitis during Cancer Immunotherapy

(2015) Mizuki Nishino et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

The Chemokine System in Innate Immunity

(2015) Caroline L. Sokol et al.   Cold Spring Harbor Perspectives in Biology

Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints

(2015) M. E. Mikucki et al.   Nature Communications

CXCR4 in breast cancer: oncogenic role and therapeutic targeting

(2015) Qinghua Yao et al.   Drug Design Development and Therapy

Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling

(2015) Laura Brandolini et al.   Oncotarget

The Role of Chemokines in Shaping the Balance Between CD4+ T Cell Subsets and Its Therapeutic Implications in Autoimmune and Cancer Diseases

(2015) Nathan Karin et al.   Frontiers in Immunology

CD4+CD25+CD127low Regulatory T Cells Play Predominant Anti-Tumor Suppressive Role in Hepatitis B Virus-Associated Hepatocellular Carcinoma

(2015) Shreya Sharma et al.   Frontiers in Immunology

Chemokine Receptor-Specific Antibodies in Cancer Immunotherapy: Achievements and Challenges

(2015) Maria Vela et al.   Frontiers in Immunology

Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model

(2015) De-Kuan Chang et al.   OncoImmunology

CTLA-4 and PD-1 Pathway Blockade: Combinations in the Clinic

(2015) Margaret K. Callahan et al.   Frontiers in Oncology

Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells

(2015) Peter S. Fenwick et al.   PLoS One

IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival

(2015) Serena Lunardi et al.   Oncotarget

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

Association of CXCR1 and 2 expressions with gastric cancer metastasis in ex vivo and tumor cell invasion in vitro

(2014) Zhen Li et al.   CYTOKINE

CXCR3 deficiency enhances tumor progression by promoting macrophage M2 polarization in a murine breast cancer model

(2014) Steve Oghumu et al.   IMMUNOLOGY

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis

(2014) Yaniv Zohar et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of anti-CCR4 monoclonal antibody (mogamulizumab) on adult T-cell leukemia-lymphoma: Cutaneous adverse reactions may predict the prognosis

(2014) Kentaro Yonekura et al.   JOURNAL OF DERMATOLOGY

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dysregulation of CXCR3 Signaling due to CXCL10 Deficiency Impairs the Antiviral Response to Herpes Simplex Virus 1 Infection

(2014) T. R. Wuest et al.   JOURNAL OF IMMUNOLOGY

CCR2-Dependent Dendritic Cell Accumulation in the Central Nervous System during Early Effector Experimental Autoimmune Encephalomyelitis Is Essential for Effector T Cell Restimulation In Situ and Disease Progression

(2014) Benjamin D. Clarkson et al.   JOURNAL OF IMMUNOLOGY

Conditional Ablation of Astroglial CCL2 Suppresses CNS Accumulation of M1 Macrophages and Preserves Axons in Mice with MOG Peptide EAE

(2014) M. Moreno et al.   JOURNAL OF NEUROSCIENCE

Heparanase enhances myeloma progression via CXCL10 downregulation

(2014) U Barash et al.   LEUKEMIA

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

(2014) Laura Bonapace et al.   NATURE

CXCL10 mRNA expression predicts response to neoadjuvant chemoradiotherapy in rectal cancer patients

(2014) Cong Li et al.   TUMOR BIOLOGY

CCL2 Chemokine as a Potential Biomarker for Prostate Cancer: A Pilot Study

(2014) Igor Tsaur et al.   Cancer Research and Treatment

Chemokines in Cancer

(2014) M. T. Chow et al.   Cancer Immunology Research

Biased and G Protein-Independent Signaling of Chemokine Receptors

(2014) Anne Steen et al.   Frontiers in Immunology

The ELR+CXCL chemokines and their receptors CXCR1/CXCR2

(2014) Sandy Giuliano et al.   OncoImmunology

p.R72P, PIN3 Ins16bp Polymorphisms of TP53 and CCR5Δ32 in North Indian Breast Cancer Patients

(2013) Kamlesh Guleria et al.   Asian Pacific Journal of Cancer Prevention

Expansion of CCR8+ Inflammatory Myeloid Cells in Cancer Patients with Urothelial and Renal Carcinomas

(2013) E. Eruslanov et al.   CLINICAL CANCER RESEARCH

Association of polymorphisms in the MCP-1 and CCR2 genes with the risk of cancer: A meta-analysis

(2013) Young Ae Cho et al.   CYTOKINE

Association of chemotactic factor receptor 5 gene with breast cancer

(2013) Y. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

CCR2 and CCR5 genes polymorphisms in benign prostatic hyperplasia and prostate cancer

(2013) Francis Maria Báo Zambra et al.   HUMAN IMMUNOLOGY

Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8+ T Cell Responses in the Lymph Node

(2013) Wolfgang Kastenmüller et al.   IMMUNITY

Evidence for the antagonistic form of CXC-motif chemokine CXCL10 in serous epithelial ovarian tumours

(2013) Adam Rainczuk et al.   INTERNATIONAL JOURNAL OF CANCER

Biased and Constitutive Signaling in the CC-chemokine Receptor CCR5 by Manipulating the Interface between Transmembrane Helices 6 and 7

(2013) Anne Steen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

(2013) Sudarshan Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of human CCR8 as a CCL18 receptor

(2013) Sabina A. Islam et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The CCL5/CCR5 axis contributes to the perineural invasion of human salivary adenoid cystic carcinoma

(2013) ZHIYUAN SHEN et al.   ONCOLOGY REPORTS

CXCL9 Associated with Sustained Virological Response in Chronic Hepatitis B Patients Receiving Peginterferon Alfa-2a Therapy: A Pilot Study

(2013) I-Cheng Lee et al.   PLoS One

CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1 and matrix metalloproteinase-2

(2012) Manik C. Ghosh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors

(2012) N. Cieri et al.   BLOOD

CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy

(2012) Sivan Sapoznik et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

PD-1 Blockade Enhances T-cell Migration to Tumors by Elevating IFN-  Inducible Chemokines

(2012) W. Peng et al.   CANCER RESEARCH

Tumoral Lymphocytic Infiltration and Expression of the Chemokine CXCL10 in Breast Cancers from the Ontario Familial Breast Cancer Registry

(2012) A. M. Mulligan et al.   CLINICAL CANCER RESEARCH

CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation

(2012) Joanna R. Groom et al.   IMMUNITY

Autocrine CCL5 Signaling Promotes Invasion and Migration of CD133+Ovarian Cancer Stem-Like Cells via NF-κB-Mediated MMP-9 Upregulation

(2012) Haixia Long et al.   STEM CELLS

Natural Innate and Adaptive Immunity to Cancer

(2011) Matthew D. Vesely et al.   Annual Review of Immunology

The chemokine receptor CCR4 promotes tumor growth and lung metastasis in breast cancer

(2011) Ji-Yu Li et al.   BREAST CANCER RESEARCH AND TREATMENT

CXCR3 in T cell function

(2011) Joanna R. Groom et al.   EXPERIMENTAL CELL RESEARCH

Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes

(2011) Anna Korniejewska et al.   IMMUNOLOGY

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ TH2 cells

(2011) Sabina A Islam et al.   NATURE IMMUNOLOGY

The role of chemokine receptor CXCR4 in lung cancer

(2010) Tara Gangadhar et al.   CANCER BIOLOGY & THERAPY

Targeting CXCR1/CXCR2 receptor antagonism in malignant melanoma

(2010) Bhawna Sharma et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV

(2010) Armanda Casrouge et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

(2010) Sergio A. Quezada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The multiple faces of CXCL12 (SDF-1α) in the regulation of immunity during health and disease

(2010) Nathan Karin   JOURNAL OF LEUKOCYTE BIOLOGY

Effect of CC chemokine ligand 5 and CC chemokine receptor 5 genes polymorphisms on the risk and clinicopathological development of oral cancer

(2010) Chia-Jui Weng et al.   ORAL ONCOLOGY

The Chemokine Receptor CCR4 is Expressed and Associated With a Poor Prognosis in Patients With Gastric Cancer

(2009) Jun Ho Lee et al.   ANNALS OF SURGERY

CCR5 Proinflammatory Allele in Prostate Cancer Risk

(2009) Carmela Rita Balistreri et al.   Annals of the New York Academy of Sciences

CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion

(2009) S Singh et al.   BRITISH JOURNAL OF CANCER

Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells

(2009) P. B. Olkhanud et al.   CANCER RESEARCH

Small-Molecule Antagonists for CXCR2 and CXCR1 Inhibit Human Melanoma Growth by Decreasing Tumor Cell Proliferation, Survival, and Angiogenesis

(2009) S. Singh et al.   CLINICAL CANCER RESEARCH

Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression

(2009) Chiara Gabellini et al.   EUROPEAN JOURNAL OF CANCER

Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion

(2009) Seema Singh et al.   INTERNATIONAL JOURNAL OF CANCER

CCR5 and p53 codon 72 gene polymorphisms: Implications in breast cancer development

(2009) Watanabe   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

CXCL10 expression and prognostic significance in stage II and III colorectal cancer

(2009) Zheng Jiang et al.   MOLECULAR BIOLOGY REPORTS

CXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis

(2008) Udai P Singh et al.   BMC IMMUNOLOGY

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

CXCL12 (SDF-1α) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells

(2008) Moran Meiron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR5 Δ32 Polymorphism: Associated with Gallbladder Cancer Susceptibility

(2008) A. Srivastava et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Association of CCL2 with Lymph Node Metastasis and Macrophage Infiltration in Oral Cavity and Lip Squamous Cell Carcinoma

(2008) Fernanda Oliveira Ferreira et al.   TUMOR BIOLOGY