Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy
Published 2018 View Full Article
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Title
Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-01-22
DOI
10.3389/fimmu.2018.00014
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Note: Only part of the references are listed.- CD4 + T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness
- (2017) Tomasz Ahrends et al. IMMUNITY
- Selected signalling proteins recruited to the T-cell receptor-CD3 complex
- (2017) Jatuporn Ngoenkam et al. IMMUNOLOGY
- Treatment of metastatic uveal melanoma with adoptive transfer of tumour-infiltrating lymphocytes: a single-centre, two-stage, single-arm, phase 2 study
- (2017) Smita S Chandran et al. LANCET ONCOLOGY
- Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
- (2017) Ugur Sahin et al. NATURE
- A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy
- (2017) Marta Łuksza et al. NATURE
- An immunogenic personal neoantigen vaccine for patients with melanoma
- (2017) Patrick A. Ott et al. NATURE
- Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer
- (2017) Sanja Stevanović et al. SCIENCE
- Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
- (2017) Whijae Roh et al. Science Translational Medicine
- TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence
- (2017) Alexandre Reuben et al. Cancer Discovery
- Human Tumor Antigens Yesterday, Today, and Tomorrow
- (2017) Olivera J. Finn Cancer Immunology Research
- Chimeric Antigen Receptor (CAR) therapy for multiple myeloma
- (2016) Djordje Atanackovic et al. BRITISH JOURNAL OF HAEMATOLOGY
- Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
- (2016) Jianjun Gao et al. CELL
- Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression
- (2016) Maria Parkhurst et al. CLINICAL CANCER RESEARCH
- TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors
- (2016) Elien M. Doorduijn et al. JOURNAL OF CLINICAL INVESTIGATION
- Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
- (2016) Roy S Herbst et al. LANCET
- Effects of miR-145 on the inhibition of chondrocyte proliferation and fibrosis by targeting TNFRSF11B in human osteoarthritis
- (2016) Guo-Dong Wang et al. Molecular Medicine Reports
- Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
- (2016) Se Jin Im et al. NATURE
- Neoantigen landscape dynamics during human melanoma–T cell interactions
- (2016) Els M. E. Verdegaal et al. NATURE
- Landscape of tumor-infiltrating T cell repertoire of human cancers
- (2016) Bo Li et al. NATURE GENETICS
- Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
- (2016) Alena Gros et al. NATURE MEDICINE
- Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
- (2016) Jesse M. Zaretsky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
- (2016) N. McGranahan et al. SCIENCE
- Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations
- (2016) Daniel Sanghoon Shin et al. Cancer Discovery
- Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor
- (2016) A. Pasetto et al. Cancer Immunology Research
- Remote Controlled CARs: Towards a Safer Therapy for Leukemia
- (2016) C. H. June Cancer Immunology Research
- Aberrant Expression of MHC Class II in Melanoma Attracts Inflammatory Tumor-Specific CD4 + T- Cells, Which Dampen CD8 + T-cell Antitumor Reactivity
- (2015) Marco Donia et al. CANCER RESEARCH
- Therapeutic cancer vaccines
- (2015) Cornelis J.M. Melief et al. JOURNAL OF CLINICAL INVESTIGATION
- CD8+CD103+Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients
- (2015) Fayçal Djenidi et al. JOURNAL OF IMMUNOLOGY
- T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
- (2015) Daniel W Lee et al. LANCET
- Mutant MHC class II epitopes drive therapeutic immune responses to cancer
- (2015) Sebastian Kreiter et al. NATURE
- Pembrolizumab versus Ipilimumab in Advanced Melanoma
- (2015) Caroline Robert et al. NEW ENGLAND JOURNAL OF MEDICINE
- Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
- (2015) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
- (2015) E. M. Van Allen et al. SCIENCE
- Neoantigens in cancer immunotherapy
- (2015) T. N. Schumacher et al. SCIENCE
- A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells
- (2015) B. M. Carreno et al. SCIENCE
- Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
- (2015) N. A. Rizvi et al. SCIENCE
- The future of immune checkpoint therapy
- (2015) P. Sharma et al. SCIENCE
- Cancer vaccines
- (2015) L. H. Butterfield BMJ-British Medical Journal
- Profiling tissue-resident T cell repertoires by RNA sequencing
- (2015) Scott D. Brown et al. Genome Medicine
- Cancer vaccines
- (2015) L. H. Butterfield BMJ-British Medical Journal
- Exome Sequencing to Predict Neoantigens in Melanoma
- (2015) A. L. Pritchard et al. Cancer Immunology Research
- Adoptive Immunotherapy for Cancer or Viruses
- (2014) Marcela V. Maus et al. Annual Review of Immunology
- A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1-Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response
- (2014) P. F. Robbins et al. CLINICAL CANCER RESEARCH
- Curing Mice with Large Tumors by Locally Delivering Combinations of Immunomodulatory Antibodies
- (2014) M. Dai et al. CLINICAL CANCER RESEARCH
- Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions
- (2014) Y.-C. Lu et al. CLINICAL CANCER RESEARCH
- PD-1 blockade induces responses by inhibiting adaptive immune resistance
- (2014) Paul C. Tumeh et al. NATURE
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- (2014) Carsten Linnemann et al. NATURE MEDICINE
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- (2014) P. Kvistborg et al. Science Translational Medicine
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- (2014) E. Cha et al. Science Translational Medicine
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- (2013) C. C. Oliveira et al. JOURNAL OF IMMUNOLOGY
- Adoptive cell therapy: Honing that killer instinct
- (2013) Courtney Humphries NATURE
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- (2013) Carsten Linnemann et al. NATURE MEDICINE
- Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
- (2013) Paul F Robbins et al. NATURE MEDICINE
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- (2013) James N. Kochenderfer et al. Nature Reviews Clinical Oncology
- CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia
- (2013) R. J. Brentjens et al. Science Translational Medicine
- Sequence analysis of T-cell repertoires in health and disease
- (2013) Daniel J Woodsworth et al. Genome Medicine
- Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
- (2013) G. L. Beatty et al. Cancer Immunology Research
- Antigen-Specific T-Cell Activation Independently of the MHC: Chimeric Antigen Receptor-Redirected T Cells
- (2013) Markus Chmielewski et al. Frontiers in Immunology
- Adoptive T-cell transfer combined with a single low dose of total body irradiation eradicates breast tumors
- (2013) Nadine M. Lerret et al. OncoImmunology
- The cancer antigenome
- (2012) Bianca Heemskerk et al. EMBO JOURNAL
- Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+T Cell Responsiveness
- (2012) Melita Irving et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation
- (2012) Adam J. Adler et al. OncoImmunology
- Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
- (2011) R. J. Brentjens et al. BLOOD
- Antigen Spreading Contributes to MAGE Vaccination-Induced Regression of Melanoma Metastases
- (2011) Véronique Corbière et al. CANCER RESEARCH
- Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
- (2011) S. A. Rosenberg et al. CLINICAL CANCER RESEARCH
- Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients
- (2011) Lukas Baitsch et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1
- (2011) Paul F. Robbins et al. JOURNAL OF CLINICAL ONCOLOGY
- Different Expression Levels of the TAP Peptide Transporter Lead to Recognition of Different Antigenic Peptides by Tumor-Specific CTL
- (2011) A. Durgeau et al. JOURNAL OF IMMUNOLOGY
- T cell exhaustion
- (2011) E John Wherry NATURE IMMUNOLOGY
- Cell transfer immunotherapy for metastatic solid cancer—what clinicians need to know
- (2011) Steven A. Rosenberg Nature Reviews Clinical Oncology
- T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia
- (2011) M. Kalos et al. Science Translational Medicine
- Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation
- (2011) Kajsa Wing et al. TRENDS IN IMMUNOLOGY
- MHC-I-restricted melanoma antigen specific TCR-engineered human CD4+ T cells exhibit multifunctional effector and helper responses, in vitro
- (2010) Swagatam Ray et al. CLINICAL IMMUNOLOGY
- Therapeutic cancer vaccines: are we there yet?
- (2010) Christopher A. Klebanoff et al. IMMUNOLOGICAL REVIEWS
- Role of CD4+Cytotoxic T Lymphocytes in the Control of Viral Diseases and Cancer
- (2010) Debora Martorelli et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
- (2010) Kaori Sakuishi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes
- (2010) Jan H Kessler et al. NATURE IMMUNOLOGY
- Production of an antigenic peptide by insulin-degrading enzyme
- (2010) Nicolas Parmentier et al. NATURE IMMUNOLOGY
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Profiling model T-cell metagenomes with short reads
- (2009) René L. Warren et al. BIOINFORMATICS
- Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
- (2009) L. A. Johnson et al. BLOOD
- Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing
- (2009) J. D. Freeman et al. GENOME RESEARCH
- Furin-Processed Antigens Targeted to the Secretory Route Elicit Functional TAP1-/-CD8+ T Lymphocytes In Vivo
- (2009) F. Medina et al. JOURNAL OF IMMUNOLOGY
- Adoptive immunotherapy for cancer: the next generation of gene-engineered immune cells
- (2009) L. J. Berry et al. TISSUE ANTIGENS
- Primer sets for cloning the human repertoire of T cell Receptor Variable regions
- (2008) Ilenia Boria et al. BMC IMMUNOLOGY
- The new paradigm of flow cell sequencing
- (2008) R. A. Holt et al. GENOME RESEARCH
- Next-generation DNA sequencing
- (2008) Jay Shendure et al. NATURE BIOTECHNOLOGY
- Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1
- (2008) Naomi N. Hunder et al. NEW ENGLAND JOURNAL OF MEDICINE
- Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen
- (2008) D. E. Speiser et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Preprocalcitonin signal peptide generates a cytotoxic T lymphocyte-defined tumor epitope processed by a proteasome-independent pathway
- (2008) F. El Hage et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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