Exploiting agonist biased signaling of chemokines to target cancer

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model

(2016) Andrew B. Kleist et al.   BIOCHEMICAL PHARMACOLOGY

Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling

(2015) I. Roy et al.   CANCER RESEARCH

Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies

(2015) Irina Kufareva et al.   IMMUNOLOGY AND CELL BIOLOGY

Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo

(2015) Dana Meyen et al.   eLife

Biased Agonism at G Protein-Coupled Receptors: The Promise and the Challenges-A Medicinal Chemistry Perspective

(2014) Jeremy Shonberg et al.   MEDICINAL RESEARCH REVIEWS

Minireview: More Than Just a Hammer: Ligand “Bias” and Pharmaceutical Discovery

(2014) Louis M. Luttrell   MOLECULAR ENDOCRINOLOGY

CXCL12 Chemokine Expression Suppresses Human Pancreatic Cancer Growth and Metastasis

(2014) Ishan Roy et al.   PLoS One

Chemokines and chemokine receptors: Update on utility and challenges for the clinician

(2014) Ishan Roy et al.   SURGERY

Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)

(2013) Joshua H. Y. Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparin Oligosaccharides Inhibit Chemokine (CXC Motif) Ligand 12 (CXCL12) Cardioprotection by Binding Orthogonal to the Dimerization Interface, Promoting Oligomerization, and Competing with the Chemokine (CXC Motif) Receptor 4 (CXCR4) N Terminus

(2012) Joshua J. Ziarek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability

(2012) T. Takekoshi et al.   MOLECULAR CANCER THERAPEUTICS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Sulfotyrosine Recognition as Marker for Druggable Sites in the Extracellular Space

(2011) Joshua J. Ziarek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

(2011) L. J. Drury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium Mobilization Triggered by the Chemokine CXCL12 Regulates Migration in Wounded Intestinal Epithelial Monolayers

(2010) Kimberle A. Agle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

CXCL12 Chemokine Expression and Secretion Regulates Colorectal Carcinoma Cell Anoikis through Bim-Mediated Intrinsic Apoptosis

(2010) Luke J. Drury et al.   PLoS One

Monomeric variants of IL-8: Effects of side chain substitutions and solution conditions upon dimer formation

(2010) Henry B. Lowman et al.   PROTEIN SCIENCE

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer

(2009) Pirus Ghadjar et al.   INTERNATIONAL JOURNAL OF CANCER

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

(2009) D. A. Zidar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12

(2009) Christopher T. Veldkamp et al.   PROTEIN SCIENCE

Constitutive CXCL12 Expression Induces Anoikis in Colorectal Carcinoma Cells

(2008) Michael K. Wendt et al.   GASTROENTEROLOGY

Chemokine receptor antagonists: overcoming developmental hurdles

(2008) Richard Horuk   NATURE REVIEWS DRUG DISCOVERY

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling