CCR8 blockade primes anti-tumor immunity through intratumoral regulatory T cells destabilization in muscle-invasive bladder cancer

Blockade of DC-SIGN+ tumor-associated macrophages reactivates anti-tumor immunity and improves immunotherapy in muscle-invasive bladder cancer

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Tumour-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer

(2019) Chao Lin et al.   GUT

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis

(2019) Christian Neumann et al.   NATURE IMMUNOLOGY

Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy

(2019) Mauro Di Pilato et al.   NATURE

Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer

(2019) Lei Wang et al.   NATURE IMMUNOLOGY

The multifaceted immune regulation of bladder cancer

(2019) Anna K. Schneider et al.   Nature Reviews Urology

Targeting CCR8 induces protective antitumor immunity and enhances vaccine-induced responses in colon cancer

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Identification and Validation of Stromal Immunotype Predict Survival and Benefit from Adjuvant Chemotherapy in Patients with Muscle-Invasive Bladder Cancer

(2018) Hangcheng Fu et al.   CLINICAL CANCER RESEARCH

Chemokines and cancer: new immune checkpoints for cancer therapy

(2018) Nathan Karin   CURRENT OPINION IN IMMUNOLOGY

Treg Destabilization and Reprogramming: Implications for Cancer Immunotherapy

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c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

(2018) Mo Xu et al.   NATURE

Treg Fragility: A Prerequisite for Effective Antitumor Immunity?

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Updated 2016 EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer

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Precision medicine for urothelial bladder cancer: update on tumour genomics and immunotherapy

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CCR8+FOXp3+Tregcells as master drivers of immune regulation

(2017) Yiftah Barsheshet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non–Small Cell Lung Cancer

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Regulatory T cells in cancer immunotherapy

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Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

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Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

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Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity

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Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

(2016) Vassiliki A. Boussiotis   NEW ENGLAND JOURNAL OF MEDICINE

Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity

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Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

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The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

(2015) M. D. Sharma et al.   Science Advances

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

STAT3 Protein Interacts with Class O Forkhead Transcription Factors in the Cytoplasm and Regulates Nuclear/Cytoplasmic Localization of FoxO1 and FoxO3a Proteins in CD4+T Cells

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Novel Foxo1-dependent transcriptional programs control Treg cell function

(2012) Weiming Ouyang et al.   NATURE

STAT3 Protein Promotes T-cell Survival and Inhibits Interleukin-2 Production through Up-regulation of Class O Forkhead Transcription Factors

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PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors: Figure 1.

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Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

(2010) Weiming Ouyang et al.   NATURE IMMUNOLOGY