Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

The Utilization of Mu-Opioid Receptor Biased Agonists: Oliceridine, an Opioid Analgesic with Reduced Adverse Effects

(2019) Ivan Urits et al.   Current Pain and Headache Reports

Biased signaling of G protein-coupled receptors – From a chemokine receptor CCR7 perspective

(2018) Astrid Sissel Jørgensen et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking

(2018) Edith Uetz-von Allmen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells

(2018) Astrid S. Jørgensen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

(2018) Timothy F Miles et al.   eLife

Structural basis for ligand recognition of the human thromboxane A2 receptor

(2018) Hengxin Fan et al.   Nature Chemical Biology

Crystal structure of the endogenous agonist-bound prostanoid receptor EP3

(2018) Kazushi Morimoto et al.   Nature Chemical Biology

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

(2018) Yosuke Toyoda et al.   Nature Chemical Biology

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV

(2017) Yi Zheng et al.   IMMUNITY

Mechanisms of Regulation of the Chemokine-Receptor Network

(2017) Martin Stone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Mechanisms of GPCR Signaling: A Structural Perspective

(2017) Vsevolod Gurevich et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemokine isoforms and processing in inflammation and immunity

(2017) Paul Proost et al.   JOURNAL OF AUTOIMMUNITY

Conformational heterogeneity in CCR7 undergoes transitions to specific states upon ligand binding

(2017) Zied Gaieb et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family

(2017) Michael J. Woolley et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model

(2016) Andrew B. Kleist et al.   BIOCHEMICAL PHARMACOLOGY

Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

(2016) Line Barington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct CCR7 glycosylation pattern shapes receptor signaling and endocytosis to modulate chemotactic responses

(2016) Mark A. Hauser et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes

(2016) M. A. Hauser et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices

(2016) Melanie P. Wescott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

(2016) Gertrud M. Hjortø et al.   Frontiers in Immunology

Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites

(2015) Christopher T. Veldkamp et al.   BIOCHEMISTRY

Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

(2015) J. S. Burg et al.   SCIENCE

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Interaction of Chemokines with their Receptors – From Initial Chemokine Binding to Receptor Activating Steps

(2014) Stefanie Thiele et al.   CURRENT MEDICINAL CHEMISTRY

Ligand-directed trafficking of receptor stimulus

(2014) Zdzisław Chilmonczyk et al.   Pharmacological Reports

Biased and G Protein-Independent Signaling of Chemokine Receptors

(2014) Anne Steen et al.   Frontiers in Immunology

Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

(2013) Prem Raj B. Joseph et al.   BIOCHEMICAL JOURNAL

Biased and Constitutive Signaling in the CC-chemokine Receptor CCR5 by Manipulating the Interface between Transmembrane Helices 6 and 7

(2013) Anne Steen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

(2013) Q. Tan et al.   SCIENCE

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Pharmacological modulation of chemokine receptor function

(2011) DJ Scholten et al.   BRITISH JOURNAL OF PHARMACOLOGY

Allosteric and Orthosteric Sites in CC Chemokine Receptor (CCR5), a Chimeric Receptor Approach

(2011) Stefanie Thiele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

(2011) Ka Young Chung et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

The minor binding pocket: a major player in 7TM receptor activation

(2010) Mette M. Rosenkilde et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation

(2010) M.C. Peeters et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Ligand binding and micro-switches in 7TM receptor structures

(2009) Rie Nygaard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY