Heparanase enhances myeloma progression via CXCL10 downregulation

Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models

(2013) G. Cassinelli et al.   BIOCHEMICAL PHARMACOLOGY

Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma

(2013) Laurence Lamy et al.   CANCER CELL

A Human ICAM-1 Antibody Isolated by a Function-First Approach Has Potent Macrophage-Dependent Antimyeloma Activity In Vivo

(2013) Niina Veitonmäki et al.   CANCER CELL

The heparanase/syndecan-1 axis in cancer: mechanisms and therapies

(2013) Vishnu C. Ramani et al.   FEBS Journal

Characterization of Heparanase-induced Phosphatidylinositol 3-Kinase-AKT Activation and Its Integrin Dependence

(2013) Anjum Riaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase Enhances the Insulin Receptor Signaling Pathway to Activate Extracellular Signal-regulated Kinase in Multiple Myeloma

(2012) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting heparanase for cancer therapy at the tumor–matrix interface

(2012) Ralph D. Sanderson et al.   MATRIX BIOLOGY

Clinical Significance of Heparanase Splice Variant (T5) in Renal Cell Carcinoma: Evaluation by a Novel T5-Specific Monoclonal Antibody

(2012) Uri Barash et al.   PLoS One

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

(2011) K Dredge et al.   BRITISH JOURNAL OF CANCER

The heparanase system and tumor metastasis: is heparanase the seed and soil?

(2011) Gil Arvatz et al.   CANCER AND METASTASIS REVIEWS

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

(2011) Joseph P. Ritchie et al.   CLINICAL CANCER RESEARCH

Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation

(2011) Victoria Cohen-Kaplan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis

(2010) A. Purushothaman et al.   BLOOD

Heparanase Enhances Local and Systemic Osteolysis in Multiple Myeloma by Upregulating the Expression and Secretion of RANKL

(2010) Y. Yang et al.   CANCER RESEARCH

Suppression of Liver Tumor Growth and Metastasis by Adiponectin in Nude Mice through Inhibition of Tumor Angiogenesis and Downregulation of Rho Kinase/IFN-Inducible Protein 10/Matrix Metalloproteinase 9 Signaling

(2010) K. Man et al.   CLINICAL CANCER RESEARCH

CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth

(2010) Katia Beider et al.   EXPERIMENTAL HEMATOLOGY

Post-transcriptional regulation of heparanase gene expression by a 3′ AU-rich element

(2010) Gil Arvatz et al.   FASEB JOURNAL

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis

(2010) Uri Barash et al.   FEBS Journal

Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity

(2010) Vishnu C. Ramani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pre-clinical and clinical significance of heparanase in Ewing’s sarcoma

(2010) Itay Shafat et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structure-Function Approach Identifies a COOH-Terminal Domain That Mediates Heparanase Signaling

(2009) L. Fux et al.   CANCER RESEARCH

A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics

(2009) Uri Barash et al.   FASEB JOURNAL

IP-10 induces dissociation of newly formed blood vessels

(2009) R. J. Bodnar et al.   JOURNAL OF CELL SCIENCE

Heparanase: busy at the cell surface

(2009) Liat Fux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis

(2008) Rachel W. Li et al.   ARTHRITIS AND RHEUMATISM

Heparanase Augments Epidermal Growth Factor Receptor Phosphorylation: Correlation with Head and Neck Tumor Progression

(2008) V. Cohen-Kaplan et al.   CANCER RESEARCH

Function of Heparanase in Prostate Tumorigenesis: Potential for Therapy

(2008) I. Lerner et al.   CLINICAL CANCER RESEARCH

Heparanase induces VEGF C and facilitates tumor lymphangiogenesis

(2008) Victoria Cohen-Kaplan et al.   INTERNATIONAL JOURNAL OF CANCER

Heparanase Stimulation of Protease Expression Implicates It as a Master Regulator of the Aggressive Tumor Phenotype in Myeloma

(2008) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCL12 (SDF-1α) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells

(2008) Moran Meiron et al.   JOURNAL OF EXPERIMENTAL MEDICINE