Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

The Chemokine Receptor CXCR3 Is Degraded following Internalization and Is Replenished at the Cell Surface by De Novo Synthesis of Receptor

(2014) A. Meiser et al.   JOURNAL OF IMMUNOLOGY

Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with Gi-protein pathway activation

(2012) Anne O. Watts et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRV120027, a Novel β-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure

(2012) Guido Boerrigter et al.   Circulation-Heart Failure

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

Cardiorenal Actions of TRV120027, a Novel ß-Arrestin–Biased Ligand at the Angiotensin II Type I Receptor, in Healthy and Heart Failure Canines

(2011) Guido Boerrigter et al.   Circulation-Heart Failure

Quantifying Ligand Bias at Seven-Transmembrane Receptors

(2011) S. Rajagopal et al.   MOLECULAR PHARMACOLOGY

Multiple ligand-specific conformations of the β2-adrenergic receptor

(2011) Alem W Kahsai et al.   Nature Chemical Biology

Critical roles of chemokine receptor CCR10 in regulating memory IgA responses in intestines

(2011) S. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

(2011) L. J. Drury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of posttranslational processing on the in vitro and in vivo activity of chemokines

(2010) Anneleen Mortier et al.   EXPERIMENTAL CELL RESEARCH

Identification of Orthosteric and Allosteric Site Mutations in M2Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias

(2010) Karen J. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

(2009) D. A. Zidar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A  -Arrestin-Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation

(2009) D. Gesty-Palmer et al.   Science Translational Medicine

On the analysis of ligand-directed signaling at G protein-coupled receptors

(2008) Frederick J. Ehlert   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY