Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting
Authors
Keywords
-
Journal
CELL PROLIFERATION
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2021-09-01
DOI
10.1111/cpr.13115
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Role of CCL2/CCR2 axis in the immunopathogenesis of rheumatoid arthritis: Latest evidence and therapeutic approaches
- (2021) Fatemeh Moadab et al. LIFE SCIENCES
- Phase I dose‐escalation trial to repurpose propagermanium, an oral CCL2 inhibitor, in patients with breast cancer
- (2020) Takaaki Masuda et al. CANCER SCIENCE
- CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis
- (2020) Hui Yang et al. Molecular Cancer
- Sex-specific adipose tissue imprinting of regulatory T cells
- (2020) Ajithkumar Vasanthakumar et al. NATURE
- Neoadjuvant checkpoint blockade for cancer immunotherapy
- (2020) Suzanne L. Topalian et al. SCIENCE
- Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers
- (2020) Ha Thi Thu Do et al. Cancers
- Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer
- (2020) Andrew M. K. Law et al. Cells
- Tumor-associated macrophages
- (2020) Luca Cassetta et al. CURRENT BIOLOGY
- Metastasis-associated fibroblasts promote angiogenesis in metastasized pancreatic cancer via the CXCL8 and the CCL2 axes
- (2020) Thomas M. Pausch et al. Scientific Reports
- Chemokines and chemokine receptors: A new strategy for breast cancer therapy
- (2020) Hui Liu et al. Cancer Medicine
- CCL2 Expression in Tumor Cells and Tumor-Infiltrating Immune Cells Shows Divergent Prognostic Potential for Bladder Cancer Patients Depending on Lymph Node Stage
- (2020) Markus Eckstein et al. Cancers
- Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis
- (2020) Timothy O. Adekoya et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cancer cell CCR2 orchestrates suppression of the adaptive immune response
- (2020) Miriam R. Fein et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Monocyte Chemoattractant Protein-1 promotes cancer cell migration via c-Raf/MAPK/AP-1 pathway and MMP-9 production in osteosarcoma
- (2020) Ju-Fang Liu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals
- (2020) Sui-Bin Ma et al. Molecular Brain
- Notch3 Knockout Suppresses Mouse Mammary Gland Development and Inhibits the Proliferation of 4T1 Murine Mammary Carcinoma Cells via CCL2/CCR4 Axis
- (2020) Wei Xiong et al. Frontiers in Cell and Developmental Biology
- Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy
- (2020) Megan M. Tu et al. Communications Biology
- Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy
- (2020) Qiu Du et al. LIFE SCIENCES
- CCR2-Dependent Recruitment of Tregs and Monocytes Following Radiotherapy Is Associated with TNFα-Mediated Resistance
- (2019) Michele Mondini et al. Cancer Immunology Research
- MCP-1/CCL2 Mediated by Autocrine Loop of PDGF-BB Promotes Invasion of Lung Cancer Cell by Recruitment of Macrophages Via CCL2–CCR2 Axis
- (2019) Mei Ding et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- The potentials of CCL 2‐ CCR 2 blockers including propagermanium as anticancer agents
- (2019) Kanae Yumimoto et al. CANCER SCIENCE
- RS 504393 inhibits M-MDSCs recruiting in immune microenvironment of bladder cancer after gemcitabine treatment
- (2019) Xing-Yu Mu et al. MOLECULAR IMMUNOLOGY
- The Neutrophil’s Role During Health and Disease
- (2019) Pei Xiong Liew et al. PHYSIOLOGICAL REVIEWS
- Metalloproteinases and their Roles in Human Cancer
- (2019) Roopali Roy et al. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
- Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma
- (2019) Marcus Noel et al. INVESTIGATIONAL NEW DRUGS
- Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications
- (2019) Yuxin Lin et al. Journal of Hematology & Oncology
- ELF-1 expression in nasopharyngeal carcinoma facilitates proliferation and metastasis of cancer cells via modulation of CCL2/CCR2 signaling
- (2019) Chang-Han Chen et al. Cancer Management and Research
- CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway
- (2019) Hiroaki Yasui et al. CLINICAL & EXPERIMENTAL METASTASIS
- Klotho‐mediated targeting of CCL 2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments
- (2019) Yangyang Liu et al. Molecular Oncology
- Structural basis of chemokine and receptor interactions: Key regulators of leukocyte recruitment in inflammatory responses
- (2019) Ram Prasad Bhusal et al. PROTEIN SCIENCE
- Tumor-Specific Regulatory T Cells from the Bone Marrow Orchestrate Antitumor Immunity in Breast Cancer
- (2019) Yingzi Ge et al. Cancer Immunology Research
- Tumor‐associated macrophages secrete CC‐chemokine ligand 2 and induce tamoxifen resistance by activating PI3K/Akt/mTOR in breast cancer
- (2019) Dongbo Li et al. CANCER SCIENCE
- CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas
- (2019) Joseph A. Flores-Toro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?
- (2018) Teizo Yoshimura Cellular & Molecular Immunology
- Chemokines: the past, the present and the future
- (2018) Peng Tang et al. Cellular & Molecular Immunology
- The regulation and importance of monocyte chemoattractant protein-1
- (2018) Vanessa Bianconi et al. CURRENT OPINION IN HEMATOLOGY
- A guide to chemokines and their receptors
- (2018) Catherine E. Hughes et al. FEBS Journal
- CCL2 conditionally determines CCL22-dependent Th2-accumulation during TGF-β-induced breast cancer progression
- (2018) Palash Kumar Mandal et al. IMMUNOBIOLOGY
- Implications of macrophage polarization in autoimmunity
- (2018) Samanta C. Funes et al. IMMUNOLOGY
- CCL2-SQSTM1 positive feedback loop suppresses autophagy to promote chemoresistance in gastric cancer
- (2018) Wenxia Xu et al. International Journal of Biological Sciences
- Overall survival in a trial of orally administered CCR2 inhibitor CCX872 in locally advanced/metastatic pancreatic cancer: Correlation with blood monocyte counts.
- (2018) David Linehan et al. JOURNAL OF CLINICAL ONCOLOGY
- High levels of CCL2 or CCL4 in the tumor microenvironment predict unfavorable survival in lung adenocarcinoma
- (2018) Lei Li et al. Thoracic Cancer
- PD-1/PD-L1 immune checkpoint: Potential target for cancer therapy
- (2018) Fatemeh K. Dermani et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Plasma Chemokine CCL2 and Its Receptor CCR2 Concentrations as Diagnostic Biomarkers for Breast Cancer Patients
- (2018) Emilia Lubowicka et al. Biomed Research International
- Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer
- (2018) Julie G Grossman et al. OncoImmunology
- Paget’s “Seed and Soil” Theory of Cancer Metastasis
- (2018) Mohammed Akhtar et al. ADVANCES IN ANATOMIC PATHOLOGY
- Role of anlotinib-induced CCL2 decrease in anti-angiogenesis and response prediction for non-small cell lung cancer therapy
- (2018) Jun Lu et al. EUROPEAN RESPIRATORY JOURNAL
- Contribution of regulatory T cells to cancer: A review
- (2018) Masoud Najafi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- T lymphocyte subsets in cancer immunity: Friends or foes
- (2018) Dounia Chraa et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Getting TANned: How the tumor microenvironment drives neutrophil recruitment
- (2018) Shuvasree SenGupta et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Therapeutic strategies involving survivin inhibition in cancer
- (2018) David Martínez‐García et al. MEDICINAL RESEARCH REVIEWS
- Turning foes to friends: targeting cancer-associated fibroblasts
- (2018) Xueman Chen et al. NATURE REVIEWS DRUG DISCOVERY
- Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists
- (2018) Anna-Katharina Apel et al. STRUCTURE
- Targeting both tumour-associated CXCR2+neutrophils and CCR2+macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma
- (2017) Timothy M Nywening et al. GUT
- Structural Analysis of Chemokine Receptor–Ligand Interactions
- (2017) Marta Arimont et al. JOURNAL OF MEDICINAL CHEMISTRY
- The CCL2-CCR2 Axis in Lymph Node Metastasis From Oral Squamous Cell Carcinoma: An Immunohistochemical Study
- (2017) Shuichi Fujita et al. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
- Perioperative cytokine levels portend early death after pancreatectomy for ductal adenocarcinoma
- (2017) Heather L. Lewis et al. JOURNAL OF SURGICAL ONCOLOGY
- The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2
- (2017) Torsten Hartwig et al. MOLECULAR CELL
- EMT and inflammation: inseparable actors of cancer progression
- (2017) Meggy Suarez-Carmona et al. Molecular Oncology
- CCL2 expression correlates with Snail expression and affects the prognosis of patients with gastric cancer
- (2017) Jia Zhang et al. PATHOLOGY RESEARCH AND PRACTICE
- Targeting CCR2 with its antagonist suppresses viability, motility and invasion by downregulating MMP-9 expression in non-small cell lung cancer cells
- (2017) Jun An et al. Oncotarget
- Role of tumor microenvironment in tumorigenesis
- (2017) Maonan Wang et al. Journal of Cancer
- A Natural CCR2 Antagonist Relieves Tumor-associated Macrophage-mediated Immunosuppression to Produce a Therapeutic Effect for Liver Cancer
- (2017) Wenbo Yao et al. EBioMedicine
- CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells
- (2016) Alan L. Chang et al. CANCER RESEARCH
- CCR2 Influences T Regulatory Cell Migration to Tumors and Serves as a Biomarker of Cyclophosphamide Sensitivity
- (2016) Pierre-Louis Loyher et al. CANCER RESEARCH
- FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling
- (2016) Xuguang Yang et al. CANCER RESEARCH
- MCP-1-induced ERK/GSK-3β/Snail signaling facilitates the epithelial–mesenchymal transition and promotes the migration of MCF-7 human breast carcinoma cells
- (2016) Shun Li et al. Cellular & Molecular Immunology
- Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma
- (2016) Anusha Kalbasi et al. CLINICAL CANCER RESEARCH
- Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial
- (2016) Timothy M Nywening et al. LANCET ONCOLOGY
- Blocking the CCL2–CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model
- (2016) Kun-Yu Teng et al. MOLECULAR CANCER THERAPEUTICS
- The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
- (2016) Vinit Kumar et al. TRENDS IN IMMUNOLOGY
- High expression of C-C chemokine receptor 2 associates with poor overall survival in gastric cancer patients after surgical resection
- (2016) Ruochen Li et al. Oncotarget
- CCL2/CCR2 axis is associated with postoperative survival and recurrence of patients with non-metastatic clear-cell renal cell carcinoma
- (2016) Zewei Wang et al. Oncotarget
- Targeting the CCL2-CCR2 signaling axis in cancer metastasis
- (2016) Su Yin Lim et al. Oncotarget
- Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling
- (2016) Hua Shen et al. PLoS Genetics
- CCL2 as a potential therapeutic target for clear cell renal cell carcinoma
- (2016) Ryuichiro Arakaki et al. Cancer Medicine
- Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma
- (2015) Xiaoguang Li et al. GUT
- Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages
- (2015) Stefano Ugel et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeted delivery of CCR2 antagonist to activated pulmonary endothelium prevents metastasis
- (2015) Marko Roblek et al. JOURNAL OF CONTROLLED RELEASE
- CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages
- (2015) Takanori Kitamura et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Chemokine System in Innate Immunity
- (2015) Caroline L. Sokol et al. Cold Spring Harbor Perspectives in Biology
- Serum chemokine (CC motif) ligand 2 level as a diagnostic, predictive, and prognostic biomarker for prostate cancer
- (2015) Kouji Izumi et al. Oncotarget
- CCL2-CCR2 axis promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2-MMP2/9 pathway
- (2015) Jing Yang et al. Oncotarget
- CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function
- (2015) Eunyoung Chun et al. Cell Reports
- Cancer metastases: challenges and opportunities
- (2015) Xiangming Guan Acta Pharmaceutica Sinica B
- Novel Markers to Delineate Murine M1 and M2 Macrophages
- (2015) Kyle A. Jablonski et al. PLoS One
- A CCL2/ROS autoregulation loop is critical for cancer-associated fibroblasts-enhanced tumor growth of oral squamous cell carcinoma
- (2014) Xia Li et al. CARCINOGENESIS
- Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
- (2014) Peter J. Murray et al. IMMUNITY
- Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
- (2014) J.-I. Youn et al. JOURNAL OF IMMUNOLOGY
- Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers
- (2014) Francois Moisan et al. Molecular Oncology
- Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis
- (2014) Laura Bonapace et al. NATURE
- New nomenclature for atypical chemokine receptors
- (2014) Françoise Bachelerie et al. NATURE IMMUNOLOGY
- Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study
- (2014) Irene Brana et al. Targeted Oncology
- The CCL2/CCR2 axis enhances IL-6-induced epithelial-mesenchymal transition by cooperatively activating STAT3-Twist signaling
- (2014) Wei Chen et al. TUMOR BIOLOGY
- Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia
- (2014) Lei-Lei Tao WORLD JOURNAL OF GASTROENTEROLOGY
- A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors
- (2013) Shahneen K. Sandhu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis
- (2013) D. E. Sanford et al. CLINICAL CANCER RESEARCH
- Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation
- (2013) Kouji Izumi et al. EMBO Molecular Medicine
- Identification of Serum Monocyte Chemoattractant Protein-1 and Prolactin as Potential Tumor Markers in Hepatocellular Carcinoma
- (2013) Who-Whong Wang et al. PLoS One
- Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway
- (2012) Monika Julia Wolf et al. CANCER CELL
- Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche
- (2012) Jaclyn Sceneay et al. CANCER RESEARCH
- Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models
- (2012) Massimo Zollo et al. CLINICAL & EXPERIMENTAL METASTASIS
- Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer
- (2012) Kenneth J. Pienta et al. INVESTIGATIONAL NEW DRUGS
- CCL2/CCR2 Chemokine Signaling Coordinates Survival and Motility of Breast Cancer Cells through Smad3 Protein- and p42/44 Mitogen-activated Protein Kinase (MAPK)-dependent Mechanisms
- (2012) Wei Bin Fang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888
- (2012) Galina Obmolova et al. MOLECULAR IMMUNOLOGY
- CCL2 increases MMP-9 expression and cell motility in human chondrosarcoma cells via the Ras/Raf/MEK/ERK/NF-κB signaling pathway
- (2011) Chih-Hsin Tang et al. BIOCHEMICAL PHARMACOLOGY
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Chemokines in tumor development and progression
- (2011) Naofumi Mukaida et al. EXPERIMENTAL CELL RESEARCH
- A MCP1 fusokine with CCR2-specific tumoricidal activity
- (2011) Moutih Rafei et al. Molecular Cancer
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
- (2011) Bin-Zhi Qian et al. NATURE
- FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
- (2011) Thierry Conroy et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Perspective on Cancer Cell Metastasis
- (2011) C. L. Chaffer et al. SCIENCE
- MCP-1: Chemoattractant with a role beyond immunity: A review
- (2010) Amita Yadav et al. CLINICA CHIMICA ACTA
- Serum CCL2 and serum TNF-α – Two new biomarkers predict bone invasion, post-treatment distant metastasis and poor overall survival in nasopharyngeal carcinoma
- (2010) Xing Lu et al. EUROPEAN JOURNAL OF CANCER
- Curcumin's Effect on Intestinal Inflammation and Tumorigenesis in the ApcMin/+ Mouse
- (2010) E. Angela Murphy et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy
- (2010) Xinmei Zhu et al. JOURNAL OF NEURO-ONCOLOGY
- The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases
- (2010) Grégory Conductier et al. JOURNAL OF NEUROIMMUNOLOGY
- Multiple Roles of Chemokine (C-C Motif) Ligand 2 in Promoting Prostate Cancer Growth
- (2010) J. Zhang et al. JNCI-Journal of the National Cancer Institute
- CCL2 Blockade Augments Cancer Immunotherapy
- (2009) Z. G. Fridlender et al. CANCER RESEARCH
- Lymphocytes in cancer development: Polarization towards pro-tumor immunity
- (2009) Brian Ruffell et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Monocyte Chemoattractant Protein-1 (MCP-1): An Overview
- (2009) Satish L. Deshmane et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone
- (2008) Yi Lu et al. CLINICAL & EXPERIMENTAL METASTASIS
- CCL2 Protects Prostate Cancer PC3 Cells from Autophagic Death via Phosphatidylinositol 3-Kinase/AKT-dependent Survivin Up-regulation
- (2008) Hernan Roca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Central Role for Tumor-derived Monocyte Chemoattractant Protein-1 in Malignant Pleural Effusion
- (2008) G. T. Stathopoulos et al. JNCI-Journal of the National Cancer Institute
- The Expression of Monocyte Chemotactic Protein-1 in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Tumor Recurrence
- (2008) Katsuhiro Tanaka et al. THYROID
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now