The Chemokine Receptor CCR7 Uses Distinct Signaling Modules With Biased Functionality to Regulate Dendritic Cells

Lymph node conduits transport virions for rapid T cell activation

(2019) Glennys V. Reynoso et al.   NATURE IMMUNOLOGY

Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation

(2019) Julia M. Laufer et al.   Cell Reports

Principles of Actomyosin Regulation In Vivo

(2018) Priti Agarwal et al.   TRENDS IN CELL BIOLOGY

Beyond Chemoattraction: Multifunctionality of Chemokine Receptors in Leukocytes

(2017) Pilar López-Cotarelo et al.   TRENDS IN IMMUNOLOGY

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

The Mammalian Sterile 20–like 1 Kinase Controls Selective CCR7-Dependent Functions in Human Dendritic Cells

(2015) Jesús Torres-Bacete et al.   JOURNAL OF IMMUNOLOGY

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

(2015) Yu Sun et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells

(2015) Pablo Vargas et al.   NATURE CELL BIOLOGY

ERK reinforces actin polymerization to power persistent edge protrusion during motility

(2015) Michelle C. Mendoza et al.   Science Signaling

ERK reinforces actin polymerization to power persistent edge protrusion during motility

(2015) Michelle C. Mendoza et al.   Science Signaling

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

A Novel MEK-ERK-AMPK Signaling Axis Controls Chemokine Receptor CCR7-dependent Survival in Human Mature Dendritic Cells

(2014) Pilar López-Cotarelo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic Cell Motility and T Cell Activation Requires Regulation of Rho-Cofilin Signaling by the Rho-GTPase Activating Protein Myosin IXb

(2014) Y. Xu et al.   JOURNAL OF IMMUNOLOGY

Detecting apoptosis of leukocytes in mouse lymph nodes

(2014) Laura Gómez-Cabañas et al.   Nature Protocols

The Directional Response of Chemotactic Cells Depends on a Balance between Cytoskeletal Architecture and the External Gradient

(2014) Ming-Jie Wang et al.   Cell Reports

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

(2013) D Westphal et al.   CELL DEATH AND DIFFERENTIATION

A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system

(2013) Iain Comerford et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cell Type-specific Signaling Function of RhoA GTPase: Lessons from Mouse Gene Targeting

(2013) Xuan Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Roles for Actin Assembly in Endocytosis

(2012) Olivia L. Mooren et al.   Annual Review of Biochemistry

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

(2012) Congying Wu et al.   CELL

Chemokine CXCL12 Uses CXCR4 and a Signaling Core Formed by Bifunctional Akt, Extracellular Signal-regulated Kinase (ERK)1/2, and Mammalian Target of Rapamycin Complex 1 (mTORC1) Proteins to Control Chemotaxis and Survival Simultaneously in Mature Dendritic Cells

(2011) Cristina Delgado-Martín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Afferent lymph–derived T cells and DCs use different chemokine receptor CCR7–dependent routes for entry into the lymph node and intranodal migration

(2011) Asolina Braun et al.   NATURE IMMUNOLOGY

Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells

(2010) H. Tanizaki et al.   BLOOD

PGE2 transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells

(2010) R. Muthuswamy et al.   BLOOD

The lymphoid chemokine CCL21 triggers LFA-1 adhesive properties on human dendritic cells

(2010) Christina Eich et al.   IMMUNOLOGY AND CELL BIOLOGY

Dendritic Cells Distinguish Individual Chemokine Signals through CCR7 and CXCR4

(2010) B. G. Ricart et al.   JOURNAL OF IMMUNOLOGY

Mature dendritic cells use endocytic receptors to capture and present antigens

(2010) C. D. Platt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of RhoGEF proteins by G12/13-coupled receptors

(2009) Sandra Siehler   BRITISH JOURNAL OF PHARMACOLOGY

CCR7-Dependent Stimulation of Survival in Dendritic Cells Involves Inhibition of GSK3 

(2009) C. Escribano et al.   JOURNAL OF IMMUNOLOGY

CCR7-specific migration to CCL19 and CCL21 is induced by PGE2 stimulation in human monocytes: Involvement of EP2/EP4 receptors activation

(2009) Sandra C. Côté et al.   MOLECULAR IMMUNOLOGY

Immunological synapse formation inhibits, via NF-κB and FOXO1, the apoptosis of dendritic cells

(2009) Lorena Riol-Blanco et al.   NATURE IMMUNOLOGY

Spatiotemporal Regulation of Ras Activity Provides Directional Sensing

(2008) Sheng Zhang et al.   CURRENT BIOLOGY

Chemokines and Their Receptors: Drug Targets in Immunity and Inflammation

(2007) Antonella Viola et al.   Annual Review of Pharmacology and Toxicology