Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands

The β4GalT1 affects the fibroblast-like synoviocytes invasion in rheumatoid arthritis by modifying N-linked glycosylation of CXCR3

(2017) Chi Sun et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Glycosaminoglycans Regulate CXCR3 Ligands at Distinct Levels: Protection against Processing by Dipeptidyl Peptidase IV/CD26 and Interference with Receptor Signaling

(2017) Mieke Metzemaekers et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemokine isoforms and processing in inflammation and immunity

(2017) Paul Proost et al.   JOURNAL OF AUTOIMMUNITY

C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways

(2017) Jeffrey S. Smith et al.   MOLECULAR PHARMACOLOGY

Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization

(2017) Douglas P. Dyer et al.   Open Biology

Intestinal Epithelial Cell Regulation of Adaptive Immune Dysfunction in Human Type 1 Diabetes

(2017) Christina L. Graves et al.   Frontiers in Immunology

CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration In Vivo through Interference with Glycosaminoglycan Interactions

(2017) Vincent Vanheule et al.   Frontiers in Immunology

Functional Toll-Like Receptor 9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis

(2016) Jasmin Schnerch et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis

(2016) Claudia Bracaglia et al.   ANNALS OF THE RHEUMATIC DISEASES

Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus

(2016) Vincent Vanheule et al.   BIOCHEMICAL PHARMACOLOGY

Pancreatic β-Cell production of CXCR3 ligands precedes diabetes onset

(2016) Susan J. Burke et al.   BIOFACTORS

Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases

(2016) R. Altara et al.   CLINICAL SCIENCE

A variant of theCXCL11gene may influence susceptibility to contact allergy, particularly in polysensitized patients

(2016) Götz A. Westphal et al.   CONTACT DERMATITIS

Inhibition of DPP4 activity in humans establishes itsin vivorole in CXCL10 post‐translational modification: prospective placebo‐controlled clinical studies

(2016) Jérémie Decalf et al.   EMBO Molecular Medicine

IL17 producing γδT cells induce angiogenesis and are associated with poor survival in gallbladder cancer patients

(2016) Rushikesh Sudam Patil et al.   INTERNATIONAL JOURNAL OF CANCER

The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions

(2016) Douglas P. Dyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-specific programming of memory CD8 T cell subsets impacts protection against lethal respiratory virus infection

(2016) Georges Abboud et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy

(2016) Vanessa Sue Wacleche et al.   Retrovirology

Microbiomic and Posttranslational Modifications as Preludes to Autoimmune Diseases

(2016) Ghislain Opdenakker et al.   TRENDS IN MOLECULAR MEDICINE

Neuroendocrine-like cells -derived CXCL10 and CXCL11 induce the infiltration of tumor-associated macrophage leading to the poor prognosis of colorectal cancer

(2016) Yu-Jie Zeng et al.   Oncotarget

CXCL9: evidence and contradictions for its role in tumor progression

(2016) Qiang Ding et al.   Cancer Medicine

The CXCL10/CXCR3 Axis and Cardiac Inflammation: Implications for Immunotherapy to Treat Infectious and Noninfectious Diseases of the Heart

(2016) Raffaele Altara et al.   Journal of Immunology Research

Ectopic Lymphoid Structures: Powerhouse of Autoimmunity

(2016) Elisa Corsiero et al.   Frontiers in Immunology

Regulation of Chemokine Activity – A Focus on the Role of Dipeptidyl Peptidase IV/CD26

(2016) Mieke Metzemaekers et al.   Frontiers in Immunology

CXCR3 ligands in disease and therapy

(2015) Katrien Van Raemdonck et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Treg-cell depletion promotes chemokine production and accumulation of CXCR3+conventional T cells in intestinal tumors

(2015) Paulina Akeus et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Hormone receptor-independent CXCL10 production is associated with the regulation of cellular factors linked to breast cancer progression and metastasis

(2015) Ahmed A. Ejaeidi et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The dependence of chemokine–glycosaminoglycan interactions on chemokine oligomerization

(2015) Douglas P Dyer et al.   GLYCOBIOLOGY

CXCR3 Chemokine Receptor Enables Local CD8+ T Cell Migration for the Destruction of Virus-Infected Cells

(2015) Heather D. Hickman et al.   IMMUNITY

The Positively Charged COOH-terminal Glycosaminoglycan-binding CXCL9(74–103) Peptide Inhibits CXCL8-induced Neutrophil Extravasation and Monosodium Urate Crystal-induced Gout in Mice

(2015) Vincent Vanheule et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets

(2015) Nathan Karin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Small Molecule CXCR3 Antagonists

(2015) Stephen P. Andrews et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy

(2015) Rosa Barreira da Silva et al.   NATURE IMMUNOLOGY

CXCL10, CXCL11, HLA-A and IL-1β are induced in peripheral blood mononuclear cells from women withChlamydia trachomatisrelated infertility

(2015) Shruti Menon et al.   Pathogens and Disease

Melanoma Induces, and Adenosine Suppresses, CXCR3-Cognate Chemokine Production and T-cell Infiltration of Lungs Bearing Metastatic-like Disease

(2015) E. Clancy-Thompson et al.   Cancer Immunology Research

Dynamic Changes of Post-Translationally Modified Forms of CXCL10 and Soluble DPP4 in HCV Subjects Receiving Interferon-Free Therapy

(2015) Eric G. Meissner et al.   PLoS One

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans

(2014) Amit Saxena et al.   CARDIOVASCULAR RESEARCH

The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases

(2014) Remo C Russo et al.   Expert Review of Clinical Immunology

Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection

(2014) Antonio Riva et al.   HEPATOLOGY

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis

(2014) Yaniv Zohar et al.   JOURNAL OF CLINICAL INVESTIGATION

The Chemokine Receptor CXCR3 Is Degraded following Internalization and Is Replenished at the Cell Surface by De Novo Synthesis of Receptor

(2014) A. Meiser et al.   JOURNAL OF IMMUNOLOGY

Infiltrated Neutrophils Acquire Novel Chemokine Receptor Expression and Chemokine Responsiveness in Chronic Inflammatory Lung Diseases

(2014) D. Hartl et al.   JOURNAL OF IMMUNOLOGY

CXCL9 and CXCL10 Expression Are Critical for Control of Genital Herpes Simplex Virus Type 2 Infection through Mobilization of HSV-Specific CTL and NK Cells to the Nervous System

(2014) M. Thapa et al.   JOURNAL OF IMMUNOLOGY

Interference with Glycosaminoglycan-Chemokine Interactions with a Probe to Alter Leukocyte Recruitment and Inflammation In Vivo

(2014) Sandra Li et al.   PLoS One

CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo

(2014) M. Rashighi et al.   Science Translational Medicine

Biased and G Protein-Independent Signaling of Chemokine Receptors

(2014) Anne Steen et al.   Frontiers in Immunology

Pericyte Regulation of Vascular Remodeling Through the CXC Receptor 3

(2013) Richard J. Bodnar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

In vivo regulation of chemokine activity by post-translational modification

(2013) Eva AV Moelants et al.   IMMUNOLOGY AND CELL BIOLOGY

Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

(2013) Sudarshan Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCR3 Deficiency Prolongs Th1-Type Contact Hypersensitivity

(2013) H. Suga et al.   JOURNAL OF IMMUNOLOGY

Fibronectin Binding Modulates CXCL11 Activity and Facilitates Wound Healing

(2013) Federico Tortelli et al.   PLoS One

Enhancement of antigen-specific CD8 T cell responses by co-delivery of Fc-fused CXCL11

(2013) Hong Namkoong et al.   VACCINE

CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral Origin

(2012) Akihiko Ichikawa et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heparins modulate the IFN-γ-induced production of chemokines in human breast cancer cells

(2012) Herbert Fluhr et al.   BREAST CANCER RESEARCH AND TREATMENT

Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR

(2012) J Vinet et al.   BRITISH JOURNAL OF PHARMACOLOGY

CXCR3+ T Regulatory Cells Selectively Accumulate in Human Ovarian Carcinomas to Limit Type I Immunity

(2012) N. Redjimi et al.   CANCER RESEARCH

Inflammatory Chemokines Direct and Restrict Leukocyte Migration within Live Tissues as Glycan-Bound Gradients

(2012) Milka Sarris et al.   CURRENT BIOLOGY

Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice

(2012) Hacer Sahin et al.   HEPATOLOGY

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

Overview of the mechanisms regulating chemokine activity and availability

(2012) Anneleen Mortier et al.   IMMUNOLOGY LETTERS

Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion

(2012) Qian Wu et al.   Molecular Cancer

Touch of Chemokines

(2012) Xavier Blanchet et al.   Frontiers in Immunology

Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3

(2011) DJ Scholten et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discrimination of agonist and antagonist forms of CXCL10 in biological samples

(2011) A. Casrouge et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CXCR3 in T cell function

(2011) Joanna R. Groom et al.   EXPERIMENTAL CELL RESEARCH

Differential expression patterns of CXCR3 variants and corresponding CXC chemokines in clear cell ovarian cancers and endometriosis

(2011) Mitsuko Furuya et al.   GYNECOLOGIC ONCOLOGY

Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes

(2011) Anna Korniejewska et al.   IMMUNOLOGY

CXCR3 ligands: redundant, collaborative and antagonistic functions

(2011) Joanna R Groom et al.   IMMUNOLOGY AND CELL BIOLOGY

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

(2011) Pavani Gangavarapu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3

(2010) S. Struyf et al.   BLOOD

The Chemokine Receptor CXCR7 Is Highly Expressed in Human Glioma Cells and Mediates Antiapoptotic Effects

(2010) K. Hattermann et al.   CANCER RESEARCH

Expression and functional role of 1F7 (CD26) antigen on peripheral blood and synovial fluid T cells in rheumatoid arthritis patients

(2010) C. MUSCAT et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Chemokines as mediators of tumor angiogenesis and neovascularization

(2010) Ellen C. Keeley et al.   EXPERIMENTAL CELL RESEARCH

Effect of posttranslational processing on the in vitro and in vivo activity of chemokines

(2010) Anneleen Mortier et al.   EXPERIMENTAL CELL RESEARCH

Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes

(2010) Xingfeng Bao et al.   IMMUNITY

Characterization of the Chemokine CXCL11-Heparin Interaction Suggests Two Different Affinities for Glycosaminoglycans

(2010) India C. Severin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Arrestins Scaffold Cofilin with Chronophin to Direct Localized Actin Filament Severing and Membrane Protrusions Downstream of Protease-activated Receptor-2

(2010) Maria Zoudilova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4

(2010) Dianhua Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV

(2010) Armanda Casrouge et al.   JOURNAL OF CLINICAL INVESTIGATION

CXC Chemokine Ligand (CXCL) 9 and CXCL10 Are Antagonistic Costimulation Molecules during the Priming of Alloreactive T Cell Effectors

(2010) J. M. Rosenblum et al.   JOURNAL OF IMMUNOLOGY

Foxp3+ IL-17+ T cells promote development of cancer-initiating cells in colorectal cancer

(2010) Shaobo Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CXCL10 Can Inhibit Endothelial Cell Proliferation Independently of CXCR3

(2010) Gabriele S. V. Campanella et al.   PLoS One

Cleavage of chemokines CCL2 and CXCL10 by matrix metalloproteinases-2 and -9: Implications for chemotaxis

(2009) Helen Denney et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biomolecular Network Reconstruction Identifies T-Cell Homing Factors Associated With Survival in Colorectal Cancer

(2009) Bernhard Mlecnik et al.   GASTROENTEROLOGY

Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses

(2009) Q. Wang et al.   JOURNAL OF IMMUNOLOGY

T cell extravasation: Demonstration of synergy between activation of CXCR3 and the T cell receptor

(2009) Peter Newton et al.   MOLECULAR IMMUNOLOGY

Fine-tuning of GPCR activity by receptor-interacting proteins

(2009) Stefanie L. Ritter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The chemokine receptors CXCR4 and CXCR3 in cancer

(2009) Amy M. Fulton   Current Oncology Reports

Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation

(2008) T. Loos et al.   BLOOD

The role of CXC chemokines and their receptors in cancer

(2008) Jo Vandercappellen et al.   CANCER LETTERS

CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-γ-induced chemokines

(2008) Philippe E. Van den Steen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Stromal cell-derived factors 1α and 1β, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8

(2008) Katerina Ajami et al.   FEBS LETTERS

Matrix Metalloproteinase Processing of CXCL11/I-TAC Results in Loss of Chemoattractant Activity and Altered Glycosaminoglycan Binding

(2008) Jennifer H. Cox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of a splice variant of CXCR3 in Crohn's disease patients; indication for a lymphocyte-epithelial cell interaction

(2008) Pinelopi Manousou et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Development of a novel chemokine-mediated in vivo T cell recruitment assay

(2008) Gabriele S.V. Campanella et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Abundant expression of CXCL9 (MIG) by stromal cells that include dendritic cells and accumulation of CXCR3+T cells in lymphocyte-rich gastric carcinoma

(2008) H Ohtani et al.   JOURNAL OF PATHOLOGY

CXCL9, but not CXCL10, Promotes CXCR3-Dependent Immune-Mediated Kidney Disease

(2008) J. Menke et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

How chemokines invite leukocytes to dance

(2008) Marcus Thelen et al.   NATURE IMMUNOLOGY

Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria

(2008) G. S. V. Campanella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA