The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders
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Title
The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders
Authors
Keywords
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Journal
Cell Death & Disease
Volume 13, Issue 2, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-02-08
DOI
10.1038/s41419-022-04593-3
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Note: Only part of the references are listed.- Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells
- (2021) Sabrina Robichaud et al. Autophagy
- The Drosophila model to interrogate triacylglycerol biology.
- (2021) Christoph Heier et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- The Role of Lipophagy in the Development and Treatment of Non-Alcoholic Fatty Liver Disease
- (2021) Aldo Grefhorst et al. Frontiers in Endocrinology
- Pro-Tumoral Functions of Autophagy Receptors in the Modulation of Cancer Progression
- (2021) Cristóbal Cerda-Troncoso et al. Frontiers in Oncology
- Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction
- (2021) Federico Giulitti et al. Frontiers in Cell and Developmental Biology
- Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis
- (2021) Chenran Wang et al. BRITISH JOURNAL OF CANCER
- Zn Induces Lipophagy via the Deacetylation of Beclin1 and Alleviates Cu-Induced Lipotoxicity at Their Environmentally Relevant Concentrations
- (2021) Xiaolei Wei et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- 1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells
- (2021) Jing Lu et al. TOXICOLOGY
- Adipocytes Provide Fatty Acids to Acute Lymphoblastic Leukemia Cells
- (2021) Jonathan Tucci et al. Frontiers in Oncology
- The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity
- (2021) Flaminia Ferri et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Fenofibrate, a PPARα agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy
- (2021) Jin Yoo et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells
- (2020) Emily Clement et al. EMBO JOURNAL
- Docosahexaenoic acid protection against palmitic acid‐induced lipotoxicity in NGF differentiated PC12 cells involves enhancement of autophagy and inhibition of apoptosis and necroptosis
- (2020) Manuel L. Montero et al. JOURNAL OF NEUROCHEMISTRY
- The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis
- (2020) Daqian Xu et al. NATURE
- Lipid droplet biogenesis: A mystery “unmixing”?
- (2020) Mike F. Renne et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Acute effects of fatty acids on autophagy in NPY neurones
- (2020) Andressa Reginato et al. JOURNAL OF NEUROENDOCRINOLOGY
- Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma
- (2020) Chan-juan Zhang et al. ACTA PHARMACOLOGICA SINICA
- The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death
- (2019) Jurgen Kriel et al. CELL DEATH AND DIFFERENTIATION
- KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover
- (2019) Diego Tapia et al. Nature Communications
- The phytochemical polydatin ameliorates non‐alcoholic steatohepatitis by restoring lysosomal function and autophagic flux
- (2019) Xiaoting Chen et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- HDAC6 regulates lipid droplet turnover in response to nutrient deprivation via p62-mediated selective autophagy
- (2019) Yan Yan et al. Journal of Genetics and Genomics
- Omega 3-DHA and Delta-Tocotrienol Modulate Lipid Droplet Biogenesis and Lipophagy in Breast Cancer Cells: the Impact in Cancer Aggressiveness
- (2019) Pizato et al. Nutrients
- Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes
- (2019) Micah B. Schott et al. JOURNAL OF CELL BIOLOGY
- Deacetylation of LAMP1 drives lipophagy‐dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer
- (2019) Prashanta Kumar Panda et al. JOURNAL OF CELLULAR PHYSIOLOGY
- LncRNA NEAT1 promotes autophagy via regulating miR‐204/ATG3 and enhanced cell resistance to sorafenib in hepatocellular carcinoma
- (2019) Xinyu Li et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Autophagy: A novel mechanism of chemoresistance in cancers
- (2019) Xinyu Li et al. BIOMEDICINE & PHARMACOTHERAPY
- Cellular quality control by the ubiquitin-proteasome system and autophagy
- (2019) Christian Pohl et al. SCIENCE
- Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes
- (2019) Geraldine Magnin et al. ACS Omega
- Lipid metabolism and lipophagy in cancer
- (2018) Meenu Maan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Diversification Patterns of Lanternfishes Reveal Multiple Rate Shifts in a Critical Mesopelagic Clade Targeted for Human Exploitation
- (2018) John S.S. Denton CURRENT BIOLOGY
- Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells
- (2018) Qing Fan et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Mechanism and medical implications of mammalian autophagy
- (2018) Ivan Dikic et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers
- (2018) Susmita Mondal et al. INTERNATIONAL JOURNAL OF CANCER
- Autophagy-dependent cell death – where, how and why a cell eats itself to death
- (2018) Shani Bialik et al. JOURNAL OF CELL SCIENCE
- Dynamics and functions of lipid droplets
- (2018) James A. Olzmann et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- ATG14 facilitated lipophagy in cancer cells induce ER stress mediated mitoptosis through a ROS dependent pathway
- (2017) Subhadip Mukhopadhyay et al. FREE RADICAL BIOLOGY AND MEDICINE
- miR-96-5p prevents hepatic stellate cell activation by inhibiting autophagy via ATG7
- (2017) Kangkang Yu et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Cytosolic lipolysis and lipophagy: two sides of the same coin
- (2017) Rudolf Zechner et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The lipid droplet: A conserved cellular organelle
- (2017) Congyan Zhang et al. Protein & Cell
- Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell
- (2017) Zili Zhang et al. Redox Biology
- Telemetric control of peripheral lipophagy by hypothalamic autophagy
- (2016) Nuria Martinez-Lopez et al. Autophagy
- The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria
- (2016) Jonathan Z. Long et al. CELL
- Lipid droplet–mediated ER homeostasis regulates autophagy and cell survival during starvation
- (2016) Ariadna P. Velázquez et al. JOURNAL OF CELL BIOLOGY
- Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency
- (2016) Benjamin L. Farah et al. JOURNAL OF HEPATOLOGY
- TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis
- (2016) Ji-An Pan et al. MOLECULAR CELL
- Protein misfolding in the endoplasmic reticulum as a conduit to human disease
- (2016) Miao Wang et al. NATURE
- A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets
- (2016) Z. Li et al. Science Advances
- Mitochondrial dysfunction in fatty acid oxidation disorders: insights from human and animal studies
- (2015) M. Wajner et al. BIOSCIENCE REPORTS
- Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics
- (2015) Angelika S. Rambold et al. DEVELOPMENTAL CELL
- Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis
- (2015) T. Shpilka et al. EMBO JOURNAL
- CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma
- (2015) Guo-Dong Lu et al. HEPATOLOGY
- The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis
- (2015) Cong Yu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role for autophagy in cancer
- (2015) Eileen White JOURNAL OF CLINICAL INVESTIGATION
- Microtargeting cancer metabolism: opening new therapeutic windows based on lipid metabolism
- (2015) Marta Gómez de Cedrón et al. JOURNAL OF LIPID RESEARCH
- Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy
- (2015) Guiyuan Ji et al. Lipids in Health and Disease
- Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
- (2015) Rushika M. Perera et al. NATURE
- Nutrient-sensing mechanisms and pathways
- (2015) Alejo Efeyan et al. NATURE
- Acylcarnitines—old actors auditioning for new roles in metabolic physiology
- (2015) Colin S. McCoin et al. Nature Reviews Endocrinology
- Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy
- (2015) S Fulda et al. ONCOGENE
- Fast clearance of lipid droplets through MAP1S-activated autophagy suppresses clear cell renal cell carcinomas and promotes patient survival
- (2015) Guibin Xu et al. Oncotarget
- Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade
- (2015) Juan F. Linares et al. Cell Reports
- OsATG7 is required for autophagy-dependent lipid metabolism in rice postmeiotic anther development
- (2014) Takamitsu Kurusu et al. Autophagy
- Neutral Lipid Stores and Lipase PNPLA5 Contribute to Autophagosome Biogenesis
- (2014) Nicolas Dupont et al. CURRENT BIOLOGY
- Cardiomyocyte-specific Loss of Diacylglycerol Acyltransferase 1 (DGAT1) Reproduces the Abnormalities in Lipids Found in Severe Heart Failure
- (2014) Li Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeast
- (2014) Chao-Wen Wang et al. JOURNAL OF CELL BIOLOGY
- Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy
- (2014) Vladimir Rogov et al. MOLECULAR CELL
- Nutrient-sensing nuclear receptors coordinate autophagy
- (2014) Jae Man Lee et al. NATURE
- Cargo recognition and trafficking in selective autophagy
- (2014) Alexandra Stolz et al. NATURE CELL BIOLOGY
- Self-consumption: the interplay of autophagy and apoptosis
- (2014) Guillermo Mariño et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Activation of mTOR pathway in myeloid-derived suppressor cells stimulates cancer cell proliferation and metastasis in lal −/− mice
- (2014) T Zhao et al. ONCOGENE
- An Overview of Autophagy: Morphology, Mechanism, and Regulation
- (2013) Katherine R. Parzych et al. ANTIOXIDANTS & REDOX SIGNALING
- Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation
- (2013) Xiaoyuan Xu et al. Cell Metabolism
- Balancing the fat: lipid droplets and human disease
- (2013) Natalie Krahmer et al. EMBO Molecular Medicine
- Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses
- (2013) D. Kenzelmann Broz et al. GENES & DEVELOPMENT
- Immunohistochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic human livers
- (2013) Jumpei Kashima et al. HEPATOLOGY RESEARCH
- Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease
- (2013) Yuka Fukuo et al. HEPATOLOGY RESEARCH
- Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice
- (2013) Chih-Wen Lin et al. JOURNAL OF HEPATOLOGY
- Autophagosomes contribute to intracellular lipid distribution in enterocytes
- (2013) Salem Ait Khaldoun et al. MOLECULAR BIOLOGY OF THE CELL
- Lipid droplet autophagy in the yeast Saccharomyces cerevisiae
- (2013) Tim van Zutphen et al. MOLECULAR BIOLOGY OF THE CELL
- MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
- (2013) Eyleen J. O’Rourke et al. NATURE CELL BIOLOGY
- Emerging regulation and functions of autophagy
- (2013) Patricia Boya et al. NATURE CELL BIOLOGY
- Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia
- (2013) Y. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of p53 in the cellular response following oleic acid accumulation in Chang liver cells
- (2013) Eun-Jung Park et al. TOXICOLOGY LETTERS
- FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment
- (2013) D Lettieri Barbato et al. Cell Death & Disease
- Regulation of lipid stores and metabolism by lipophagy
- (2012) K Liu et al. CELL DEATH AND DIFFERENTIATION
- Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation
- (2012) Kosei Eguchi et al. Cell Metabolism
- Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues
- (2012) Virginia Hernández–Gea et al. GASTROENTEROLOGY
- Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice
- (2012) Li Liu et al. JOURNAL OF LIPID RESEARCH
- Plk1-Dependent Phosphorylation of Optineurin Provides a Negative Feedback Mechanism for Mitotic Progression
- (2012) David Kachaner et al. MOLECULAR CELL
- Therapeutic Delivery of siRNA Silencing HIF-1 Alpha with Micellar Nanoparticles Inhibits Hypoxic Tumor Growth
- (2012) Xi-Qiu Liu et al. MOLECULAR PHARMACEUTICS
- Targeting autophagy for the treatment of liver diseases
- (2012) Hong-Min Ni et al. PHARMACOLOGICAL RESEARCH
- Autophagy regulates lipolysis and cell survival through lipid droplet degradation in androgen-sensitive prostate cancer cells
- (2012) Ramesh R. Kaini et al. PROSTATE
- Regulation of lipid metabolism by p53 – fighting two villains with one sword
- (2012) Ido Goldstein et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- Regulation of Lipid Droplet Cholesterol Efflux From Macrophage Foam Cells
- (2011) Mireille Ouimet et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Selective taste of ethanol-induced autophagy for mitochondria and lipid droplets
- (2011) Wen-Xing Ding et al. Autophagy
- Chasing the elusive mammalian microautophagy
- (2011) Laura Santambrogio et al. Autophagy
- Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression
- (2011) Yoshihiro Inami et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance
- (2011) Susmita Kaushik et al. Cell Metabolism
- Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans
- (2011) Louis R. Lapierre et al. CURRENT BIOLOGY
- Microautophagy of Cytosolic Proteins by Late Endosomes
- (2011) Ranjit Sahu et al. DEVELOPMENTAL CELL
- Pancreatic cancers require autophagy for tumor growth
- (2011) S. Yang et al. GENES & DEVELOPMENT
- The role of lipid droplets in metabolic disease in rodents and humans
- (2011) Andrew S. Greenberg et al. JOURNAL OF CLINICAL INVESTIGATION
- A role for autophagy during hepatic stellate cell activation
- (2011) Lien F.R. Thoen et al. JOURNAL OF HEPATOLOGY
- Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study
- (2011) S Shen et al. ONCOGENE
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
- (2011) R. Zoncu et al. SCIENCE
- Autophagy in nonalcoholic steatohepatitis
- (2011) Muhammad Amir et al. Expert Review of Gastroenterology & Hepatology
- Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
- (2010) Ling Yang et al. Cell Metabolism
- Autophagy-related lipase FgATG15 of Fusarium graminearum is important for lipid turnover and plant infection
- (2010) Long Nam Nguyen et al. FUNGAL GENETICS AND BIOLOGY
- Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice
- (2010) Wen–Xing Ding et al. GASTROENTEROLOGY
- Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress
- (2010) Yongjun Wang et al. HEPATOLOGY
- PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation
- (2010) Ni-Huiping Son et al. JOURNAL OF CLINICAL INVESTIGATION
- Evaluation of the C.Diff Quik Chek Complete Assay, a New Glutamate Dehydrogenase and A/B Toxin Combination Lateral Flow Assay for Use in Rapid, Simple Diagnosis of Clostridium difficile Disease
- (2010) S. E. Sharp et al. JOURNAL OF CLINICAL MICROBIOLOGY
- Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation
- (2010) V. M. Hubbard et al. JOURNAL OF IMMUNOLOGY
- Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
- (2010) Marta Martinez-Vicente et al. NATURE NEUROSCIENCE
- Critical Roles of Lysosomal Acid Lipase in T Cell Development and Function
- (2009) Peng Qu et al. AMERICAN JOURNAL OF PATHOLOGY
- Regulation Mechanisms and Signaling Pathways of Autophagy
- (2009) Congcong He et al. Annual Review of Genetics
- DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity
- (2009) Li Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy regulates lipid metabolism
- (2009) Rajat Singh et al. NATURE
- Autophagic cell death: the story of a misnomer
- (2008) Guido Kroemer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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