Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction

(2014) Michael P. Weekes et al.   CELL

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

(2013) Nikolaj H.T. Petersen et al.   CANCER CELL

In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation

(2013) Paulo A. Gameiro et al.   Cell Metabolism

Exploiting the bad eating habits of Ras-driven cancers

(2013) E. White   GENES & DEVELOPMENT

An Extended Proteome Map of the Lysosomal Membrane Reveals Novel Potential Transporters

(2013) Agnès Chapel et al.   MOLECULAR & CELLULAR PROTEOMICS

Beta-Like Importins Mediate the Nuclear Translocation of Mitogen-Activated Protein Kinases

(2013) E. Zehorai et al.   MOLECULAR AND CELLULAR BIOLOGY

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Killing from the inside

(2013) Paul Saftig et al.   NATURE

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increasing the Multiplexing Capacity of TMTs Using Reporter Ion Isotopologues with Isobaric Masses

(2012) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis

(2012) Lior Golomb et al.   MOLECULAR CELL

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis

(2011) R. B. Corcoran et al.   CANCER RESEARCH

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Biology and Clinical Relevance of the Micropthalmia Family of Transcription Factors in Human Cancer

(2011) Rizwan Haq et al.   JOURNAL OF CLINICAL ONCOLOGY

MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics

(2011) Lily Ting et al.   NATURE METHODS

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Nuclear import by karyopherin-βs: Recognition and inhibition

(2010) Yuh Min Chook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

A cation counterflux supports lysosomal acidification

(2010) Benjamin E. Steinberg et al.   JOURNAL OF CELL BIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Lysosomal disorders: From storage to cellular damage

(2008) Andrea Ballabio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Preferential Utilization of Imp7/8 in Nuclear Import of Smads

(2008) Xiaohao Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE