Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells

Periprostatic adipose tissue favors prostate cancer cell invasion in an obesity- dependent manner: role of oxidative stress

(2019) Victor Laurent et al.   MOLECULAR CANCER RESEARCH

A lipase-independent pathway of lipid release and immune modulation by adipocytes

(2019) Stephen E. Flaherty et al.   SCIENCE

Anthropometric factors and Breslow thickness: Prospective data on 2570 cutaneous melanoma cases in the population-based Janus Cohort

(2018) J.S. Stenehjem et al.   BRITISH JOURNAL OF DERMATOLOGY

Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis

(2018) Jennifer L McQuade et al.   LANCET ONCOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins

(2018) Maomao Zhang et al.   Cancer Discovery

Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

(2018) K. Verboven et al.   Scientific Reports

Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming

(2018) Victoire Gouirand et al.   Frontiers in Oncology

Circulating Extracellular Vesicles in Human Disease

(2018) Ravi Shah et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

(2018) Clair Crewe et al.   CELL

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Lipid Storage and Autophagy in Melanoma Cancer Cells

(2017) Claudia Giampietri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Obesity and melanoma: could fat be fueling malignancy?

(2017) Emily Clement et al.   Pigment Cell & Melanoma Research

The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance

(2017) Minh Ngoc Duong et al.   Oncotarget

Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer

(2016) Ikrame Lazar et al.   CANCER RESEARCH

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Elevated Serum Leptin Levels are Associated With an Increased Risk of Sentinel Lymph Node Metastasis in Cutaneous Melanoma

(2016) Junna Oba et al.   MEDICINE

AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion

(2016) Brian Cunniff et al.   MOLECULAR BIOLOGY OF THE CELL

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Metformin in Cancer Treatment and Prevention

(2015) Daniel R. Morales et al.   Annual Review of Medicine

Enhanced OXPHOS, glutaminolysis and  -oxidation constitute the metastatic phenotype of melanoma cells

(2015) M. F. Rodrigues et al.   BIOCHEMICAL JOURNAL

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality

(2015) Emily Jane Gallagher et al.   PHYSIOLOGICAL REVIEWS

Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines

(2015) Ikrame Lazar et al.   Pigment Cell & Melanoma Research

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

(2015) Albert Herms et al.   Nature Communications

Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes

(2014) Jovan Kuzmicic et al.   BIOCHEMICAL PHARMACOLOGY

High-fat diet-induced obesity increases lymphangiogenesis and lymph node metastasis in the B16F10 melanoma allograft model: Roles of adipocytes and M2-macrophages

(2014) Jae In Jung et al.   INTERNATIONAL JOURNAL OF CANCER

Subcutaneous Adipocytes Promote Melanoma Cell Growth by Activating the Akt Signaling Pathway

(2014) Hiu Yee Kwan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of obesity on the thickness of primary cutaneous melanoma

(2014) F. Skowron et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Obesity and cancer—mechanisms underlying tumour progression and recurrence

(2014) Jiyoung Park et al.   Nature Reviews Endocrinology

Adipose tissue and adipocytes support tumorigenesis and metastasis

(2013) Kristin M. Nieman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mitochondrial Localization and the Persistent Migration of Epithelial Cancer cells

(2013) Salil P. Desai et al.   BIOPHYSICAL JOURNAL

Excess body weight and increased Breslow thickness in melanoma patients

(2013) Vincenzo de Giorgi et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

A new method for the measurement of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2

(2012) John Hamilton et al.   CLINICA CHIMICA ACTA

Obesity and risk of malignant melanoma: A meta-analysis of cohort and case–control studies

(2012) Theodoros N. Sergentanis et al.   EUROPEAN JOURNAL OF CANCER

Identification of the Hypoxia-inducible Factor 2α Nuclear Interactome in Melanoma Cells Reveals Master Proteins Involved in Melanoma Development

(2012) Anne-Lise Steunou et al.   MOLECULAR & CELLULAR PROTEOMICS

Mitochondrial dynamics regulates migration and invasion of breast cancer cells

(2012) J Zhao et al.   ONCOGENE

A Comparative Study of Gene-Expression Data of Basal Cell Carcinoma and Melanoma Reveals New Insights about the Two Cancers

(2012) Kun Xu et al.   PLoS One

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

(2011) B. Dirat et al.   CANCER RESEARCH

Diet-induced obesity increases melanoma progression: Involvement of Cav-1 and FASN

(2011) Vimal Pandey et al.   INTERNATIONAL JOURNAL OF CANCER

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Thiadiazole Carbamates: Potent Inhibitors of Lysosomal Acid Lipase and Potential Niemann−Pick Type C Disease Therapeutics

(2010) Anton I. Rosenbaum et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial dysfunction during in vitro hepatocyte steatosis is reversed by omega-3 fatty acid–induced up-regulation of mitofusin 2

(2010) Yong Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

(2010) Achim Lass et al.   PROGRESS IN LIPID RESEARCH

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Brn-2 Represses Microphthalmia-Associated Transcription Factor Expression and Marks a Distinct Subpopulation of Microphthalmia-Associated Transcription Factor-Negative Melanoma Cells

(2008) J. Goodall et al.   CANCER RESEARCH

Obesity and diabetes: lipids, ‘nowhere to run to'

(2008) Margaret J. Hill et al.   CLINICAL SCIENCE

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

(2008) Andrew G Renehan et al.   LANCET