The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death

The potentially conflicting cell autonomous and cell non-autonomous functions of autophagy in mediating tumor response to cancer therapy

(2018) David A. Gewirtz et al.   BIOCHEMICAL PHARMACOLOGY

Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization

(2018) Punya Bhat et al.   BIOCHEMICAL PHARMACOLOGY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Precision oncology in the age of integrative genomics

(2018) Chandan Kumar-Sinha et al.   NATURE BIOTECHNOLOGY

The autophagic network and cancer

(2018) Marissa D. Rybstein et al.   NATURE CELL BIOLOGY

Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death

(2018) Isabelle Martins et al.   Cell Death & Disease

Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics

(2018) Jurgen Kriel et al.   Scientific Reports

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagic flux control in neurodegeneration: Progress and precision targeting—Where do we stand?

(2017) Dumisile Lumkwana et al.   PROGRESS IN NEUROBIOLOGY

Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity

(2017) Peng Tan et al.   TRENDS IN BIOTECHNOLOGY

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak

(2017) Jason Karch et al.   eLife

Entosis: The emerging face of non-cell-autonomous type IV programmed death

(2017) Isabelle Martins et al.   Biomedical Journal

Autophagy—A free meal in sickness-associated anorexia

(2016) Gustav van Niekerk et al.   Autophagy

Phosphorylation of Atg9 regulates movement to the phagophore assembly site and the rate of autophagosome formation

(2016) Yuchen Feng et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

An Autophagic Flux Probe that Releases an Internal Control

(2016) Takeshi Kaizuka et al.   MOLECULAR CELL

MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin

(2015) Nunu Huang et al.   CANCER BIOLOGY & THERAPY

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Autosis occurs in the liver of patients with severe anorexia nervosa

(2015) Marouane Kheloufi et al.   HEPATOLOGY

Fenretinide induces autophagic cell death in caspase-defective breast cancer cells

(2014) Barbara Fazi et al.   Autophagy

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

(2014) Reshma Rangwala et al.   Autophagy

Combined MTOR and autophagy inhibition

(2014) Reshma Rangwala et al.   Autophagy

Defining and measuring autophagosome flux—concept and reality

(2014) Ben Loos et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Quantitative indices of autophagy activity from minimal models

(2014) Kyungreem Han et al.   Theoretical Biology and Medical Modelling

Metabolism addiction in pancreatic cancer

(2014) R Blum et al.   Cell Death & Disease

Autosis: a new addition to the cell death tower of babel

(2014) C Muñoz-Pinedo et al.   Cell Death & Disease

Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion

(2014) R. Lock et al.   Cancer Discovery

Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site

(2013) Ikuko Koyama-Honda et al.   Autophagy

The variability of autophagy and cell death susceptibility

(2013) Ben Loos et al.   Autophagy

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy

(2013) Keiji Tanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma

(2013) Laurence Lamy et al.   CANCER CELL

Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells

(2013) Xudong Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divergent Roles of Autophagy in Virus Infection

(2013) Abhilash Chiramel et al.   Cells

AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization

(2012) Hildegard I.D. Mack et al.   Autophagy

Mechanisms of Ploidy Increase in Human Cancers: A New Role for Cell Cannibalism

(2012) M. Krajcovic et al.   CANCER RESEARCH

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signaling pathways

(2012) Yan Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A cellular stress-directed bistable switch controls the crosstalk between autophagy and apoptosis

(2012) Orsolya Kapuy et al.   Molecular BioSystems

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200

(2011) Eugenia Morselli et al.   CELL CYCLE

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Core signaling pathways of survival/death in autophagy-related cancer networks

(2011) Shu-ya Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival

(2011) Mohamed Elgendy et al.   MOLECULAR CELL

BH3 mimetics activate multiple pro-autophagic pathways

(2011) S A Malik et al.   ONCOGENE

Larval midgut destruction in Drosophila: Not dependent on caspases but suppressed by the loss of autophagy

(2010) Donna Denton et al.   Autophagy

Acetylated microtubules are required for fusion of autophagosomes with lysosomes

(2010) Rui Xie et al.   BMC CELL BIOLOGY

Stimulation of autophagy by the p53 target gene Sestrin2

(2010) Maria Chiara Maiuri et al.   CELL CYCLE

Starvation-induced Hyperacetylation of Tubulin Is Required for the Stimulation of Autophagy by Nutrient Deprivation

(2010) Camille Geeraert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell death: A dynamic response concept

(2009) Benjamin Loos et al.   Autophagy

Acetylated tubulin associates with the fifth cytoplasmic domain of Na+/K+-ATPase: possible anchorage site of microtubules to the plasma membrane

(2009) Guillermo G. Zampar et al.   BIOCHEMICAL JOURNAL

Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila

(2009) Donna Denton et al.   CURRENT BIOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

Ankyrin facilitates intracellular trafficking of α1-Na+-K+-ATPase in polarized cells

(2008) Paul R. Stabach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Life, death and burial: multifaceted impact of autophagy

(2008) Lorenzo Galluzzi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Acute Liver Cell Damage in Patients With Anorexia Nervosa: A Possible Role of Starvation-Induced Hepatocyte Autophagy

(2008) Pierre–Emmanuel Rautou et al.   GASTROENTEROLOGY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY