Galectin-3 inhibitors: a patent review (2008–present)

Endothelial integrin α3β1 stabilizes carbohydrate-mediated tumor/endothelial cell adhesion and induces macromolecular signaling complex formation at the endothelial cell membrane

(2015) Olga V. Glinskii et al.   Oncotarget

Synergistic Effects of PectaSol-C Modified Citrus Pectin an Inhibitor of Galectin-3 and Paclitaxel on Apoptosis of Human SKOV-3 Ovarian Cancer Cells

(2014) Ghamartaj Hossein et al.   Asian Pacific Journal of Cancer Prevention

Galectin-3 binds to MUC1-N-terminal domain and triggers recruitment of β-catenin in MUC1-expressing mouse 3T3 cells

(2014) Shuhei Tanida et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Galectin-3 in cancer

(2014) Lin Song et al.   CLINICA CHIMICA ACTA

Nuclear transport of galectin-3 and its therapeutic implications

(2014) Tatsuyoshi Funasaka et al.   SEMINARS IN CANCER BIOLOGY

Galectin-3 Accelerates M2 Macrophage Infiltration and Angiogenesis in Tumors

(2013) Weizhen Jia et al.   AMERICAN JOURNAL OF PATHOLOGY

Peptides derived from human galectin-3 N-terminal tail interact with its carbohydrate recognition domain in a phosphorylation-dependent manner

(2013) M. Álvaro Berbís et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Investigation into the Feasibility of Thioditaloside as a Novel Scaffold for Galectin-3-Specific Inhibitors

(2013) Khuchtumur Bum-Erdene et al.   CHEMBIOCHEM

Human Galectin-3 Selective and High Affinity Inhibitors. Present State and Future Perspectives

(2013) R. Tellez-Sanz et al.   CURRENT MEDICINAL CHEMISTRY

Predictive value of serum galectin-3 levels in patients with acute heart failure with preserved ejection fraction

(2013) Francisco Javier Carrasco-Sánchez et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Galectin-3 Guides Intracellular Trafficking of Some Human Serotransferrin Glycoforms

(2013) Michael C. Carlsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Inhibitory Effects of a Rhamnogalacturonan Ι (RG-I) Domain from Ginseng Pectin on Galectin-3 and Its Structure-Activity Relationship

(2013) Xiaoge Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1

(2013) Hilde van Hattum et al.   JOURNAL OF MEDICINAL CHEMISTRY

Galectin-3 Interactions with Glycosphingolipids

(2013) Patrick M. Collins et al.   JOURNAL OF MOLECULAR BIOLOGY

Suppression of SERPINA1-albumin complex formation by galectin-3 overexpression leads to paracrine growth promotion of chronic myelogenous leukemia cells

(2013) Ryuko Nakayama et al.   LEUKEMIA RESEARCH

Therapy of Experimental NASH and Fibrosis with Galectin Inhibitors

(2013) Peter G. Traber et al.   PLoS One

Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease

(2013) Peter G. Traber et al.   PLoS One

Cod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostate cancer metastasis

(2013) P. Guha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide–Drug Conjugate Linked via a Disulfide Bond for Kidney Targeted Drug Delivery

(2012) Qian Geng et al.   BIOCONJUGATE CHEMISTRY

Galectin-3 binds to CD45 on diffuse large B-cell lymphoma cells to regulate susceptibility to cell death

(2012) M. C. Clark et al.   BLOOD

Galectin-3 Contributes to Melanoma Growth and Metastasis via Regulation of NFAT1 and Autotaxin

(2012) R. R. Braeuer et al.   CANCER RESEARCH

Inhibition of metastatic tumor formation in vivo by a bacteriophage display-derived galectin-3 targeting peptide

(2012) Jessica R. Newton-Northup et al.   CLINICAL & EXPERIMENTAL METASTASIS

Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression

(2012) Yuan-Guo Wang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress

(2011) Koichi Ito et al.   ANGIOGENESIS

The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

(2011) Kadhirvel Saraboji et al.   BIOCHEMISTRY

When Galectins Recognize Glycans: From Biochemistry to Physiology and Back Again

(2011) Santiago Di Lella et al.   BIOCHEMISTRY

Treatment of prostate carcinoma with (Galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates

(2011) Yang Yang et al.   BIOMATERIALS

Taloside Inhibitors of Galectin-1 and Galectin-3

(2011) Patrick M. Collins et al.   Chemical Biology & Drug Design

Structural aspects of binding of α-linked digalactosides to human galectin-1

(2011) Michelle C Miller et al.   GLYCOBIOLOGY

The Anti-angiogenic Peptide Anginex Greatly Enhances Galectin-1 Binding Affinity for Glycoproteins

(2011) Emma Salomonsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-3 maintains cell motility from the subventricular zone to the olfactory bulb

(2011) I. Comte et al.   JOURNAL OF CELL SCIENCE

An Integrated Computational Analysis of the Structure, Dynamics, and Ligand Binding Interactions of the Human Galectin Network

(2011) Carlos M. A. Guardia et al.   Journal of Chemical Information and Modeling

Galectin-3 (Gal-3) induced by leukemia microenvironment promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia

(2011) M. Yamamoto-Sugitani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

(2010) Bader A. Salameh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

(2010) Kimberley A. Stannard et al.   CANCER LETTERS

A Galectin-3 Ligand Corrects the Impaired Function of Human CD4 and CD8 Tumor-Infiltrating Lymphocytes and Favors Tumor Rejection in Mice

(2010) N. Demotte et al.   CANCER RESEARCH

Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

(2010) Carl Diehl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of Prostate Cancer Progression by Galectin-3

(2009) Yi Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

The carbohydrate-binding domain on galectin-1 is more extensive for a complex glycan than for simple saccharides: implications for galectin–glycan interactions at the cell surface

(2009) Michelle C. Miller et al.   BIOCHEMICAL JOURNAL

Dynamics of galectin-3 in the nucleus and cytoplasm

(2009) Kevin C. Haudek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The  -galactomannan Davanat binds galectin-1 at a site different from the conventional galectin carbohydrate binding domain

(2009) M. C Miller et al.   GLYCOBIOLOGY

Gastrosplenic Fistula From Hodgkin's Lymphoma

(2009) Carolyn D. Seib et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumor targeting and SPECT imaging properties of an 111In-labeled galectin-3 binding peptide in prostate carcinoma

(2009) Susan L. Deutscher et al.   NUCLEAR MEDICINE AND BIOLOGY

Fragment-based development of triazole-substituted O-galactosyl aldoximes with fragment-induced affinity and selectivity for galectin-3

(2009) Johan Tejler et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death

(2009) N. G. Than et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unlike mammalian GRIFIN, the zebrafish homologue (DrGRIFIN) represents a functional carbohydrate-binding galectin

(2008) Hafiz Ahmed et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein subtype-targeting through ligand epimerization: Talose-selectivity of galectin-4 and galectin-8

(2008) Christopher T. Öberg et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modified citrus pectin anti-metastatic properties: one bullet, multiple targets

(2008) Vladislav V. Glinsky et al.   CARBOHYDRATE RESEARCH

Arginine Binding Motifs: Design and Synthesis of Galactose-Derived Arginine Tweezers as Galectin-3 Inhibitors

(2008) Christopher T. Öberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

111In-Labeled Galectin-3-Targeting Peptide as a SPECT Agent for Imaging Breast Tumors

(2008) S. R. Kumar et al.   JOURNAL OF NUCLEAR MEDICINE

Crystal structure of the C-terminal conserved domain of human GRP, a galectin-related protein, reveals a function mode different from those of galectins

(2008) Dongwen Zhou et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Crystal structure of the putative carbohydrate recognition domain of human galectin-related protein

(2008) Martin Andreas Wälti et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS