Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia

(2019) Bing Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis

(2019) Mark Esposito et al.   NATURE CELL BIOLOGY

Inhibition of fucosylation in human invasive ductal carcinoma reduces E-selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation

(2018) Mylène A. Carrascal et al.   Molecular Oncology

The cytokine network in acute myeloid leukemia (AML): A focus on pro- and anti-inflammatory mediators

(2018) Stephanie Binder et al.   CYTOKINE & GROWTH FACTOR REVIEWS

FUT4 is involved in PD-1-related immunosuppression and leads to worse survival in patients with operable lung adenocarcinoma

(2018) Chang Liu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Recruited monocytic myeloid-derived suppressor cells promote the arrest of tumor cells in the premetastatic niche through an IL-1β-mediated increase in E-selectin expression

(2017) Huifang Shi et al.   INTERNATIONAL JOURNAL OF CANCER

An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer

(2017) Noam Auslander et al.   Molecular Systems Biology

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Increased fucosylation has a pivotal role in multidrug resistance of breast cancer cells through miR-224-3p targeting FUT4

(2016) Xiaobin Feng et al.   GENE

Glycosylation: a hallmark of cancer?

(2016) Bhairavi N. Vajaria et al.   GLYCOCONJUGATE JOURNAL

Imprinting of Skin/Inflammation Homing in CD4+T Cells Is Controlled by DNA Methylation within theFucosyltransferase 7Gene

(2016) Matthias Pink et al.   JOURNAL OF IMMUNOLOGY

Fucosyltransferase IV (FUT4) as an effective biomarker for the diagnosis of breast cancer

(2015) Xiaomei Yan et al.   BIOMEDICINE & PHARMACOTHERAPY

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

(2014) D. R. Pattabiraman et al.   BLOOD

ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes

(2014) N. Mondal et al.   BLOOD

Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML

(2014) Andrew Volk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic regulation of MDR1 gene through post-translational histone modifications in prostate cancer

(2013) Rui Henrique et al.   BMC GENOMICS

Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

Overlapping roles for endothelial selectins in murine hematopoietic stem/progenitor cell homing to bone marrow

(2013) L. Karina Nabors et al.   EXPERIMENTAL HEMATOLOGY

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Leukemia Mediated Endothelial Cell Activation Modulates Leukemia Cell Susceptibility to Chemotherapy through a Positive Feedback Loop Mechanism

(2013) Bahareh Pezeshkian et al.   PLoS One

Nichotherapy for stem cells: There goes the neighborhood

(2012) Jean-Pierre Levesque et al.   BIOESSAYS

Pharmacologic stabilization of HIF-1  increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

(2012) C. E. Forristal et al.   BLOOD

Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands

(2012) W. H. Yang et al.   BLOOD

Glycosylation effects on cancer development

(2012) Sen-itiroh Hakomori et al.   GLYCOCONJUGATE JOURNAL

B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2

(2012) I. G. Winkler et al.   HAEMATOLOGICA

Silencing α1,3-Fucosyltransferases in Human Leukocytes Reveals a Role for FUT9 Enzyme during E-selectin-mediated Cell Adhesion

(2012) Alexander Buffone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

(2012) Ingrid G Winkler et al.   NATURE MEDICINE

Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice

(2010) Jean-Emmanuel Sarry et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells

(2010) Y. Saito et al.   Science Translational Medicine

Mouse models of human AML accurately predict chemotherapy response

(2009) J. Zuber et al.   GENES & DEVELOPMENT