Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation

STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion

(2019) Chuan-xia Zhang et al.   CELL DEATH AND DIFFERENTIATION

Galectin-9 inhibits TLR7-mediated autoimmunity in murine lupus models

(2018) Santosh K. Panda et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Lgals9 Deficiency in Attenuating Nephritis and Arthritis in BALB/c Mice in a Pristane-Induced Lupus Model

(2018) Sonia Zeggar et al.   Arthritis & Rheumatology

Galectin-9 Expression Predicts Favorable Clinical Outcome in Solid Tumors: A Systematic Review and Meta-Analysis

(2018) Xiaoxiang Zhou et al.   Frontiers in Physiology

Galectin-9 is an easy to measure biomarker for the interferon signature in systemic lupus erythematosus and antiphospholipid syndrome

(2018) Lucas L van den Hoogen et al.   ANNALS OF THE RHEUMATIC DISEASES

Galectins Control MTOR and AMPK in Response to Lysosomal Damage to Induce Autophagy

(2018) Jingyue Jia et al.   Autophagy

Avelumab versus docetaxel in patients with platinum-treated advanced non-small-cell lung cancer (JAVELIN Lung 200): an open-label, randomised, phase 3 study

(2018) Fabrice Barlesi et al.   LANCET ONCOLOGY

ΔNp63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer

(2018) Sushil Kumar et al.   JOURNAL OF CLINICAL INVESTIGATION

Galectin-9: Diverse roles in hepatic immune homeostasis and inflammation

(2017) Lucy Golden-Mason et al.   HEPATOLOGY

Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling

(2017) Aruna Bitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory T Cell–Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9

(2017) Shravan Madireddi et al.   JOURNAL OF IMMUNOLOGY

Nivolumab treatment for oesophageal squamous-cell carcinoma: an open-label, multicentre, phase 2 trial

(2017) Toshihiro Kudo et al.   LANCET ONCOLOGY

Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial

(2017) Christopher R Heery et al.   LANCET ONCOLOGY

The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2

(2017) Torsten Hartwig et al.   MOLECULAR CELL

Expansion of CD11b + Ly-6C + myeloid-derived suppressor cells (MDSCs) driven by galectin-9 attenuates CVB3-induced myocarditis

(2017) Yingying Zhang et al.   MOLECULAR IMMUNOLOGY

Prostaglandin E2 Leads to the Acquisition of DNMT3A-Dependent Tolerogenic Functions in Human Myeloid-Derived Suppressor Cells

(2017) Javier Rodríguez-Ubreva et al.   Cell Reports

Long-term Survival and Clinical Benefit from Adoptive T-cell Transfer in Stage IV Melanoma Patients Is Determined by a Four-Parameter Tumor Immune Signature

(2017) Sara M. Melief et al.   Cancer Immunology Research

Galectin-9: From cell biology to complex disease dynamics

(2016) Sebastian John et al.   JOURNAL OF BIOSCIENCES

The host STING pathway at the interface of cancer and immunity

(2016) Leticia Corrales et al.   JOURNAL OF CLINICAL INVESTIGATION

A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression

(2015) Yoshikane Kikushige et al.   Cell Stem Cell

Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial

(2015) Jeffrey S Weber et al.   LANCET ONCOLOGY

Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions

(2014) K. Nagahara et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal Stem Cells Tune the Development of Monocyte-Derived Dendritic Cells Toward a Myeloid-Derived Suppressive Phenotype through Growth-Regulated Oncogene Chemokines

(2013) H.-W. Chen et al.   JOURNAL OF IMMUNOLOGY

Galectin-9 Functionally Impairs Natural Killer Cells in Humans and Mice

(2013) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9

(2012) M. K. Gleason et al.   BLOOD

Cytomegalovirus Impairs Antiviral CD8+ T Cell Immunity by Recruiting Inflammatory Monocytes

(2012) Lisa P. Daley-Bauer et al.   IMMUNITY

Host–tumor interactions in nasopharyngeal carcinomas

(2012) Claire Gourzones et al.   SEMINARS IN CANCER BIOLOGY

Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice

(2011) Norman Woller et al.   JOURNAL OF CLINICAL INVESTIGATION

Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells

(2010) V. Dardalhon et al.   JOURNAL OF IMMUNOLOGY

Characterization of Cytokine-Induced Myeloid-Derived Suppressor Cells from Normal Human Peripheral Blood Mononuclear Cells

(2010) M. G. Lechner et al.   JOURNAL OF IMMUNOLOGY

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice

(2008) Shuiping Tu et al.   CANCER CELL

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE