Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development

Control of osteoblast regeneration by a train of Erk activity waves

(2021) Alessandro De Simone et al.   NATURE

Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis

(2021) Mamoru Ishii et al.   eLife

Engineering organoids

(2021) Moritz Hofer et al.   Nature Reviews Materials

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

(2021) Bas Ponsioen et al.   NATURE CELL BIOLOGY

Fast, cell-resolution, contiguous-wide two-photon imaging to reveal functional network architectures across multi-modal cortical areas

(2021) Keisuke Ota et al.   NEURON

Democratising deep learning for microscopy with ZeroCostDL4Mic

(2021) Lucas von Chamier et al.   Nature Communications

Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

(2021) Kazuhide S Okuda et al.   eLife

Mechanical forces shaping the development of the inner ear

(2021) Roie Cohen et al.   BIOPHYSICAL JOURNAL

Shedding light on developmental ERK signaling with genetically encoded biosensors

(2021) Akinobu Nakamura et al.   DEVELOPMENT

Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies

(2021) Keishi Kishimoto et al.   DEVELOPMENT

Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival

(2021) Paolo Armando Gagliardi et al.   DEVELOPMENTAL CELL

Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination

(2021) Léo Valon et al.   DEVELOPMENTAL CELL

High-speed, cortex-wide volumetric recording of neuroactivity at cellular resolution using light beads microscopy

(2021) Jeffrey Demas et al.   NATURE METHODS

Mathematical modeling of Erk activity waves in regenerating zebrafish scales

(2021) Luke D. Hayden et al.   BIOPHYSICAL JOURNAL

Diesel2p mesoscope with dual independent scan engines for flexible capture of dynamics in distributed neural circuitry

(2021) Che-Hang Yu et al.   Nature Communications

Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration

(2021) Shuhao Lin et al.   Life Science Alliance

Coupling delay controls synchronized oscillation in the segmentation clock

(2020) Kumiko Yoshioka-Kobayashi et al.   NATURE

Recent advances in the use of genetically encodable optical tools to elicit and monitor signaling events

(2020) Ha Neul Lee et al.   CURRENT OPINION IN CELL BIOLOGY

Recapitulating the human segmentation clock with pluripotent stem cells

(2020) Mitsuhiro Matsuda et al.   NATURE

Intravital imaging of mouse embryos

(2020) Qiang Huang et al.   SCIENCE

ERK signaling dynamics in the morphogenesis and homeostasis of Drosophila

(2020) Shigeo Hayashi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization

(2020) Naoya Hino et al.   DEVELOPMENTAL CELL

ERK signalling: a master regulator of cell behaviour, life and fate

(2020) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of ERK basal and pulsatile activity control proliferation and exit from the stem cell compartment in mammalian epidermis

(2020) Toru Hiratsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live Visualization of ERK Activity in the Mouse Blastocyst Reveals Lineage-Specific Signaling Dynamics

(2020) Claire S. Simon et al.   DEVELOPMENTAL CELL

Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo

(2020) Michael J. Pokrass et al.   DEVELOPMENTAL CELL

Theory of mechanochemical patterning and optimal migration in cell monolayers

(2020) Daniel Boocock et al.   Nature Physics

Species-specific segmentation clock periods are due to differential biochemical reaction speeds

(2020) Mitsuhiro Matsuda et al.   SCIENCE

Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells

(2020) Keishi Kishimoto et al.   Nature Communications

Incoherent Feedforward Regulation via Sox9 and ERK Underpins Mouse Tracheal Cartilage Development

(2020) Takuya Yoshida et al.   Frontiers in Cell and Developmental Biology

Cellpose: a generalist algorithm for cellular segmentation

(2020) Carsen Stringer et al.   NATURE METHODS

A design principle for posttranslational chaotic oscillators

(2020) Hiroto Q. Yamaguchi et al.   iScience

Noise-resistant developmental reproducibility in vertebrate somite formation

(2019) Honda Naoki et al.   PLoS Computational Biology

Organoids by design

(2019) Takanori Takebe et al.   SCIENCE

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

FRET as a biomolecular research tool — understanding its potential while avoiding pitfalls

(2019) W. Russ Algar et al.   NATURE METHODS

EGFR family and Src family kinase interactions: mechanics matters?

(2018) Zhongwen Chen et al.   CURRENT OPINION IN CELL BIOLOGY

ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock

(2018) Marina Matsumiya et al.   DEVELOPMENT

Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation

(2018) Kana Ishimatsu et al.   DEVELOPMENT

A Switch-like Activation Relay of EGFR-ERK Signaling Regulates a Wave of Cellular Contractility for Epithelial Invagination

(2018) Yosuke Ogura et al.   DEVELOPMENTAL CELL

Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine

(2018) Yu Muta et al.   Nature Communications

A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging

(2018) Naoki Komatsu et al.   Scientific Reports

Time-lapse observation of stepwise regression of Erk activity in zebrafish presomitic mesoderm

(2018) Dini Wahyu Kartika Sari et al.   Scientific Reports

Outstanding questions in developmental ERK signaling

(2018) Aleena L. Patel et al.   DEVELOPMENT

Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation

(2018) Anneliis Ihermann-Hella et al.   Stem Cell Reports

Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks

(2018) Eric C. Greenwald et al.   CHEMICAL REVIEWS

Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation

(2018) Eduardo Moreno et al.   CURRENT BIOLOGY

Spatial and temporal inhibition of FGFR2b ligands reveals continuous requirements and novel targets in mouse inner ear morphogenesis

(2018) Lisa D. Urness et al.   DEVELOPMENT

ERK Activity Dynamics during Zebrafish Embryonic Development

(2018) Kah-Loon Wong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells

(2017) Karl R Koehler et al.   NATURE BIOTECHNOLOGY

Live-cell measurements of kinase activity in single cells using translocation reporters

(2017) Takamasa Kudo et al.   Nature Protocols

The Growing and Glowing Toolbox of Fluorescent and Photoactive Proteins

(2017) Erik A. Rodriguez et al.   TRENDS IN BIOCHEMICAL SCIENCES

Relaxation oscillations and hierarchy of feedbacks in MAPK signaling

(2017) Marek Kochańczyk et al.   Scientific Reports

Activation of Erk in ileal epithelial cells engaged in ischemic-injury repair

(2017) Haruna Takeda et al.   Scientific Reports

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Fgf10 is required for specification of non-sensory regions of the cochlear epithelium

(2015) Lisa D. Urness et al.   DEVELOPMENTAL BIOLOGY

Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development

(2015) Christophe Frémin et al.   Cell Reports

Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin

(2015) Toru Hiratsuka et al.   eLife

The Fibroblast Growth Factor signaling pathway

(2015) David M. Ornitz et al.   Wiley Interdisciplinary Reviews-Developmental Biology

High-Sensitivity Measurements of Multiple Kinase Activities in Live Single Cells

(2014) Sergi Regot et al.   CELL

Crucial requirement of ERK/MAPK signaling in respiratory tract development

(2014) O. Boucherat et al.   DEVELOPMENT

Actomyosin bundles serve as a tension sensor and a platform for ERK activation

(2014) H. Hirata et al.   EMBO REPORTS

Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution

(2014) Bi-Chang Chen et al.   SCIENCE

Lung mesenchymal expression of Sox9 plays a critical role in tracheal development

(2013) Gianluca Turcatel et al.   BMC BIOLOGY

Reporter Mouse Lines for Fluorescence Imaging

(2013) Takaya Abe et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation

(2013) Kazuhiro Aoki et al.   MOLECULAR CELL

The ErbB/HER family of protein-tyrosine kinases and cancer

(2013) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways

(2013) E. A. Hines et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Roles of Pulsing in Genetic Circuits

(2013) J. H. Levine et al.   SCIENCE

Live Imaging of Protein Kinase Activities in Transgenic Mice Expressing FRET Biosensors

(2012) Yuji Kamioka et al.   CELL STRUCTURE AND FUNCTION

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

(2012) John G. Albeck et al.   MOLECULAR CELL

Scaling of embryonic patterning based on phase-gradient encoding

(2012) Volker M. Lauschke et al.   NATURE

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

Development of Probes for Cellular Functions Using Fluorescent Proteins and Fluorescence Resonance Energy Transfer

(2011) Atsushi Miyawaki   Annual Review of Biochemistry

Shaping sound in space: the regulation of inner ear patterning

(2011) A. K. Groves et al.   DEVELOPMENT

Development of an optimized backbone of FRET biosensors for kinases and GTPases

(2011) Naoki Komatsu et al.   MOLECULAR BIOLOGY OF THE CELL

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

(2011) R. Fritsche-Guenther et al.   Molecular Systems Biology

Feedback regulation of EGFR signalling: decision making by early and delayed loops

(2011) Roi Avraham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

(2011) Yukio Nakamura et al.   Nature Communications

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

FGF10 controls the patterning of the tracheal cartilage rings via Shh

(2010) F. G. Sala et al.   DEVELOPMENT

Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage

(2009) Jinhyung Park et al.   DEVELOPMENTAL DYNAMICS

Morphometric analysis of testis cord formation inSox9-EGFPmice

(2009) Liesl Nel-Themaat et al.   DEVELOPMENTAL DYNAMICS

Rapid and sustained nuclear–cytoplasmic ERK oscillations induced by epidermal growth factor

(2009) Harish Shankaran et al.   Molecular Systems Biology

Cell fate decisions are specified by the dynamic ERK interactome

(2009) Alex von Kriegsheim et al.   NATURE CELL BIOLOGY

Fibroblast Growth Factor 10 Plays a Causative Role in the Tracheal Cartilage Defects in a Mouse Model of Apert Syndrome

(2009) Caterina Tiozzo et al.   PEDIATRIC RESEARCH

L-Sox5 and Sox6 Drive Expression of the Aggrecan Gene in Cartilage by Securing Binding of Sox9 to a Far-Upstream Enhancer

(2008) Y. Han et al.   MOLECULAR AND CELLULAR BIOLOGY

A genetically encoded fluorescent sensor of ERK activity

(2008) C. D. Harvey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

(2008) J. Newbern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA