Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells

Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation

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Anatomical and physiological development of the human inner ear

(2016) Rebecca Lim et al.   HEARING RESEARCH

Single-cell analysis delineates a trajectory toward the human early otic lineage

(2016) Megan Ealy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells

(2016) Xiao-Ping Liu et al.   Nature Communications

Genetic Correction of Induced Pluripotent Stem Cells From a Deaf Patient With MYO7A Mutation Results in Morphologic and Functional Recovery of the Derived Hair Cell-Like Cells

(2016) Zi-Hua Tang et al.   Stem Cells Translational Medicine

Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture

(2016) Rachel E. DeJonge et al.   PLoS One

Modeling mouse and human development using organoid cultures

(2015) M. Huch et al.   DEVELOPMENT

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

(2015) Takeshi Maruyama et al.   NATURE BIOTECHNOLOGY

ScaleS: an optical clearing palette for biological imaging

(2015) Hiroshi Hama et al.   NATURE NEUROSCIENCE

New treatment options for hearing loss

(2015) Ulrich Müller et al.   NATURE REVIEWS DRUG DISCOVERY

Limited hair cell induction from human induced pluripotent stem cells using a simple stepwise method

(2015) Hiroe Ohnishi et al.   NEUROSCIENCE LETTERS

Identification and characterization of mouse otic sensory lineage genes

(2015) Byron H. Hartman et al.   Frontiers in Cellular Neuroscience

Caenorhabditis elegans is a useful model for anthelmintic discovery

(2015) Andrew R. Burns et al.   Nature Communications

3D mouse embryonic stem cell culture for generating inner ear organoids

(2014) Karl R Koehler et al.   Nature Protocols

Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be?

(2014) R Michael Roberts et al.   REPRODUCTION

Sound Strategies for Hearing Restoration

(2014) G. S. G. Geleoc et al.   SCIENCE

Inner Ear Hair Cell-Like Cells from Human Embryonic Stem Cells

(2014) Mohammad Ronaghi et al.   STEM CELLS AND DEVELOPMENT

Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from human embryonic stem cells

(2013) Alan W. Leung et al.   DEVELOPMENTAL BIOLOGY

Age-Related Cochlear Synaptopathy: An Early-Onset Contributor to Auditory Functional Decline

(2013) Y. Sergeyenko et al.   JOURNAL OF NEUROSCIENCE

Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture

(2013) Karl R. Koehler et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Production of hepatocyte-like cells from human pluripotent stem cells

(2013) Nicholas R F Hannan et al.   Nature Protocols

Robust Formation and Maintenance of Continuous Stratified Cortical Neuroepithelium by Laminin-Containing Matrix in Mouse ES Cell Culture

(2013) Makoto Nasu et al.   PLoS One

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

The function and molecular identity of inward rectifier channels in vestibular hair cells of the mouse inner ear

(2012) Michaela E. Levin et al.   JOURNAL OF NEUROPHYSIOLOGY

Restoration of auditory evoked responses by human ES-cell-derived otic progenitors

(2012) Wei Chen et al.   NATURE

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

(2012) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions

(2012) Jeanette Beers et al.   Nature Protocols

Shaping sound in space: the regulation of inner ear patterning

(2011) A. K. Groves et al.   DEVELOPMENT

HCN Channels Expressed in the Inner Ear Are Necessary for Normal Balance Function

(2011) G. C. Horwitz et al.   JOURNAL OF NEUROSCIENCE

Genetic engineering of human pluripotent cells using TALE nucleases

(2011) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

Connecting the ear to the brain: Molecular mechanisms of auditory circuit assembly

(2011) Jessica M. Appler et al.   PROGRESS IN NEUROBIOLOGY

From shared lineage to distinct functions: the development of the inner ear and epibranchial placodes

(2010) R. K. Ladher et al.   DEVELOPMENT

Identification of Early Requirements for Preplacodal Ectoderm and Sensory Organ Development

(2010) Hye-Joo Kwon et al.   PLoS Genetics