Recapitulating the human segmentation clock with pluripotent stem cells

Homozygous DMRT2 variant associates with severe rib malformations in a newborn

(2018) Arjan Bouman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock

(2018) Marina Matsumiya et al.   DEVELOPMENT

Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells

(2018) Taiki Nakajima et al.   DEVELOPMENT

Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information

(2017) Akihiro Isomura et al.   GENES & DEVELOPMENT

The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells

(2017) Ian J. Huggins et al.   Nature Communications

In Vivo Human Somitogenesis Guides Somite Development from hPSCs

(2017) Haibin Xi et al.   Cell Reports

Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types

(2016) Kyle M. Loh et al.   CELL

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

(2016) Mohammad A. Mandegar et al.   Cell Stem Cell

Identification of a novel LRRK1 mutation in a family with osteosclerotic metaphyseal dysplasia

(2016) Long Guo et al.   JOURNAL OF HUMAN GENETICS

Novel and recurrent XYLT1 mutations in two Turkish families with Desbuquois dysplasia, type 2

(2016) Long Guo et al.   JOURNAL OF HUMAN GENETICS

Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro

(2016) Jérome Chal et al.   Nature Protocols

Building the backbone: the development and evolution of vertebral patterning

(2015) A. Fleming et al.   DEVELOPMENT

Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy

(2015) Jérome Chal et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

A Simple and Robust Method for Establishing Homogeneous Mouse Epiblast Stem Cell Lines by Wnt Inhibition

(2015) Michihiko Sugimoto et al.   Stem Cell Reports

Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs

(2015) Akihiro Yamashita et al.   Stem Cell Reports

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Small molecule-directed specification of sclerotome-like chondroprogenitors and induction of a somitic chondrogenesis program from embryonic stem cells

(2014) J. Zhao et al.   DEVELOPMENT

Compound heterozygous mutations in RIPPLY2 associated with vertebral segmentation defects

(2014) Aideen M. McInerney-Leo et al.   HUMAN MOLECULAR GENETICS

Signalling dynamics in vertebrate segmentation

(2014) Alexis Hubaud et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

GWASTools: an R/Bioconductor package for quality control and analysis of genome-wide association studies

(2012) S. M. Gogarten et al.   BIOINFORMATICS

Scaling of embryonic patterning based on phase-gradient encoding

(2012) Volker M. Lauschke et al.   NATURE

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling

(2012) Yusuke Okubo et al.   Nature Communications

Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines

(2011) Christoph Bock et al.   CELL

Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis

(2011) Y. Niwa et al.   GENES & DEVELOPMENT

Dickkopf1 - A New Player in Modelling the Wnt Pathway

(2011) Lykke Pedersen et al.   PLoS One

Analyzing circadian expression data by harmonic regression based on autoregressive spectral estimation

(2010) R. Yang et al.   BIOINFORMATICS

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Mutations in the MESP2 Gene Cause Spondylothoracic Dysostosis/Jarcho-Levin Syndrome

(2008) Alberto S. Cornier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutation of HAIRY-AND-ENHANCER-OF-SPLIT-7 in humans causes spondylocostal dysostosis

(2008) D. B. Sparrow et al.   HUMAN MOLECULAR GENETICS

Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation

(2008) T. Wataya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA