Iron homeostasis and organismal aging

Ferric iron reductases and their contribution to unicellular ferrous iron uptake

(2021) Timothy J. Cain et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

An IRON-clad Connection between Aging Organelles

(2020) Hongying Shen   CELL

The turquoise killifish: a genetically tractable model for the study of aging

(2020) Michael Poeschla et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

SnapShot: Ferroptosis

(2020) Kamyar Hadian et al.   CELL

Genetic screens reveal CCDC115 as a modulator of erythroid iron and heme trafficking

(2020) Amin Sobh et al.   AMERICAN JOURNAL OF HEMATOLOGY

Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-β Load

(2020) Pratishtha Chatterjee et al.   JOURNAL OF ALZHEIMERS DISEASE

Basics and principles of cellular and systemic iron homeostasis

(2020) Angeliki Katsarou et al.   MOLECULAR ASPECTS OF MEDICINE

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

(2020) Erika Kelmer Sacramento et al.   Molecular Systems Biology

Differences in the frequency of genetic variants associated with iron imbalance among global populations

(2020) Momodou W. Jallow et al.   PLoS One

Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

(2020) Paul R. H. J. Timmers et al.   Nature Communications

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

(2020) Nicole L Jenkins et al.   eLife

A guide to assessing cellular senescence in vitro and in vivo

(2020) Estela González‐Gualda et al.   FEBS Journal

Age-Related Changes and Sex-Related Differences in Brain Iron Metabolism

(2020) Tanja Grubić Kezele et al.   Nutrients

miR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma

(2019) Kamesh R. Babu et al.   Scientific Reports

New insights into the links between hypoxia and iron homeostasis

(2019) Cyril Renassia et al.   CURRENT OPINION IN HEMATOLOGY

Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography

(2019) Ryan K. Muir et al.   ACS Central Science

Telomere shortening rate predicts species life span

(2019) Kurt Whittemore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Autophagy and Aging on Iron Load and Ferritin in Drosophila Brain

(2019) Anne-Claire Jacomin et al.   Frontiers in Cell and Developmental Biology

Iron Metabolism in the Peripheral Nervous System: The Role of DMT1, Ferritin, and Transferrin Receptor in Schwann Cell Maturation and Myelination

(2019) Diara A. Santiago González et al.   JOURNAL OF NEUROSCIENCE

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis

(2019) Morgane Rosendale et al.   Nature Communications

Hepcidin and Anemia: A Tight Relationship

(2019) Alessia Pagani et al.   Frontiers in Physiology

Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging

(2019) Anna Cozzi et al.   Stem Cell Reports

Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle

(2019) Anna Picca et al.   Cells

Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases

(2018) Gerwyn Morris et al.   BEHAVIOURAL BRAIN RESEARCH

Activity-based sensing fluorescent probes for iron in biological systems

(2018) Allegra T Aron et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mobilization of iron from ferritin: new steps and details

(2018) A. La et al.   Metallomics

The significance, trafficking and determination of labile iron in cytosol, mitochondria and lysosomes

(2018) Huanhuan Lv et al.   Metallomics

Iron promotes oxidative cell death caused by bisretinoids of retina

(2018) Keiko Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Aging of Iron Man

(2018) Azhaar Ashraf et al.   Frontiers in Aging Neuroscience

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications

(2018) Jun-Lin Liu et al.   Frontiers in Neuroscience

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

Mitochondrial Iron in Human Health and Disease

(2018) Diane M. Ward et al.   Annual Review of Physiology

Anemia of inflammation

(2018) Guenter Weiss et al.   BLOOD

Liver iron sensing and body iron homeostasis

(2018) Chia-Yu Wang et al.   BLOOD

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury

(2018) Elizabeth M. Kenny et al.   CRITICAL CARE MEDICINE

Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess

(2018) Courtney J. Mercadante et al.   HAEMATOLOGICA

Association between Body Iron Status and Leukocyte Telomere Length, a Biomarker of Biological Aging, in a Nationally Representative Sample of US Adults

(2018) Buyun Liu et al.   Journal of the Academy of Nutrition and Dietetics

Modern iron replacement therapy: clinical and pathophysiological insights

(2017) Domenico Girelli et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Iron homeostasis: An anthropocentric perspective

(2017) Richard Coffey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The elemental role of iron in DNA synthesis and repair

(2017) Sergi Puig et al.   Metallomics

Ferroptosis and cell death mechanisms in Parkinson's disease

(2017) Stephanie J. Guiney et al.   NEUROCHEMISTRY INTERNATIONAL

Green tea polyphenols require the mitochondrial iron transporter,mitoferrin, for lifespan extension inDrosophila melanogaster

(2016) Terry E. Lopez et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Hepcidin regulation in the anemia of inflammation

(2016) Chia-Yu Wang et al.   CURRENT OPINION IN HEMATOLOGY

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Impact of Oxidative Stress in Premature Aging and Iron Overload in Hemodialysis Patients

(2016) Blanca Murillo-Ortiz et al.   Oxidative Medicine and Cellular Longevity

Effect of Systemic Iron Overload and a Chelation Therapy in a Mouse Model of the Neurodegenerative Disease Hereditary Ferritinopathy

(2016) Holly J. Garringer et al.   PLoS One

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondria and Iron: current questions

(2016) Bibbin T. Paul et al.   Expert Review of Hematology

Iron promotes protein insolubility and aging in C. elegans

(2016) Ida M. Klang et al.   Aging-US

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

Age-dependent expression of duodenal cytochrome b divalent metal transporter 1, ferroportin 1, and hephaestin in the duodenum of rats

(2015) Wei-Na Kong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Iron regulatory proteins and their role in controlling iron metabolism

(2015) Lukas C. Kühn   Metallomics

Genome-Wide Identification of Fas/CD95 Alternative Splicing Regulators Reveals Links with Iron Homeostasis

(2015) J. Ramón Tejedor et al.   MOLECULAR CELL

Mechanistic and regulatory aspects of intestinal iron absorption

(2014) Sukru Gulec et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Molecular liaisons between erythropoiesis and iron metabolism

(2014) L. Kautz et al.   BLOOD

The active role of vitamin C in mammalian iron metabolism: Much more than just enhanced iron absorption!

(2014) Darius J.R. Lane et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia-Inducible Factors Link Iron Homeostasis and Erythropoiesis

(2014) Yatrik M. Shah et al.   GASTROENTEROLOGY

Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants

(2014) Tanja Jaeggi et al.   GUT

Iron and mechanisms of emotional behavior

(2014) Jonghan Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

The Multicopper Ferroxidase Hephaestin Enhances Intestinal Iron Absorption in Mice

(2014) Brie K. Fuqua et al.   PLoS One

Increased Iron Sequestration in Alveolar Macrophages in Chronic Obtructive Pulmonary Disease

(2014) Quentin Philippot et al.   PLoS One

Clinically Approved Iron Chelators Influence Zebrafish Mortality, Hatching Morphology and Cardiac Function

(2014) Jasmine L. Hamilton et al.   PLoS One

Alternative splicing contributes to the coordinated regulation of ferritin subunit levels in Bactrocera dorsalis (Hendel)

(2014) Xuan-Zhao Jiang et al.   Scientific Reports

Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration

(2014) Scott Ayton et al.   Biomed Research International

Labile iron in cells and body fluids: physiology, pathology, and pharmacology

(2014) Zvi Ioav Cabantchik   Frontiers in Pharmacology

Iron deficiency in the elderly population, revisited in the hepcidin era

(2014) Fabiana Busti et al.   Frontiers in Pharmacology

The role of TMPRSS6/matriptase-2 in iron regulation and anemia

(2014) Chia-Yu Wang et al.   Frontiers in Pharmacology

Evaluation and management of anemia in the elderly

(2013) Lawrence Tim Goodnough et al.   AMERICAN JOURNAL OF HEMATOLOGY

HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis

(2013) Carine White et al.   Cell Metabolism

Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation

(2013) Caiyong Chen et al.   Cell Metabolism

Transcriptional regulation by hypoxia inducible factors

(2013) Veronica L. Dengler et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Aging-related changes in the iron status of skeletal muscle

(2013) Keith C. DeRuisseau et al.   EXPERIMENTAL GERONTOLOGY

Plasma hepcidin levels and anemia in old age. The Leiden 85-Plus Study

(2013) W. P. J. den Elzen et al.   HAEMATOLOGICA

Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age

(2013) B. J. McCranor et al.   HAEMATOLOGICA

Each Member of the Poly-r(C)-binding Protein 1 (PCBP) Family Exhibits Iron Chaperone Activity toward Ferritin

(2013) Sebastien Leidgens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron status in the elderly

(2013) Susan J. Fairweather-Tait et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Heme and FLVCR-related transporter families SLC48 and SLC49

(2013) Anwar A. Khan et al.   MOLECULAR ASPECTS OF MEDICINE

Dietary Iron Concentration May Influence Aging Process by Altering Oxidative Stress in Tissues of Adult Rats

(2013) Lorena Fernandes Arruda et al.   PLoS One

Influence of microRNA on the Maintenance of Human Iron Metabolism

(2013) McKale Davis et al.   Nutrients

Out of Balance—Systemic Iron Homeostasis in Iron-Related Disorders

(2013) Andrea Steinbicker et al.   Nutrients

Multi-Copper Oxidases and Human Iron Metabolism

(2013) Ganna Vashchenko et al.   Nutrients

Iron Biology, Immunology, Aging, and Obesity: Four Fields Connected by the Small Peptide Hormone Hepcidin

(2013) Maria Carlota Dao et al.   Advances in Nutrition

Heme carrier protein 1 transports heme and is involved in heme-Fe metabolism

(2012) Solange Le Blanc et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein degradation and iron homeostasis

(2012) Joel W. Thompson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Assessing Cell and Organ Senescence Biomarkers

(2012) Bruno Bernardes de Jesus et al.   CIRCULATION RESEARCH

Heme metabolism and erythropoiesis

(2012) Jacky Chung et al.   CURRENT OPINION IN HEMATOLOGY

Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice

(2012) Zhuzhen Zhang et al.   HEPATOLOGY

TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia

(2012) Peng An et al.   HUMAN MOLECULAR GENETICS

Impaired Iron Status in Aging Research

(2012) Jinze Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Micromanaging Iron Homeostasis

(2012) Yusuke Yoshioka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZIP8 Is an Iron and Zinc Transporter Whose Cell-surface Expression Is Up-regulated by Cellular Iron Loading

(2012) Chia-Yu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys

(2012) E. K. Kastman et al.   JOURNAL OF NEUROSCIENCE

Increased ferritin levels could reflect ongoing aging-associated inflammation and may obscure underlying iron deficiency in the geriatric population

(2012) M. Cankurtaran et al.   European Geriatric Medicine

Genetics of longevity. Data from the studies on Sicilian centenarians

(2012) Carmela R Balistreri et al.   Immunity & Ageing

Aging is an organ-specific process: changes in homeostasis of iron and redox proteins in the rat

(2011) Baruch E. Bulvik et al.   AGE

Non-transferrin bound iron: A key role in iron overload and iron toxicity

(2011) Pierre Brissot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

(2011) D. Meynard et al.   BLOOD

TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals

(2011) A. Nai et al.   BLOOD

Hepcidin and iron regulation, 10 years later

(2011) T. Ganz   BLOOD

Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy

(2011) Jinze Xu et al.   EXPERIMENTAL GERONTOLOGY

The role of endocytic pathways in cellular uptake of plasma non-transferrin iron

(2011) Y.-S. Sohn et al.   HAEMATOLOGICA

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

(2011) Mirco Castoldi et al.   JOURNAL OF CLINICAL INVESTIGATION

Unexplained Anemia Predominates Despite an Intensive Evaluation in a Racially Diverse Cohort of Older Adults From a Referral Anemia Clinic

(2011) A. S. Artz et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Iron metabolism and the innate immune response to infection

(2011) Erin E. Johnson et al.   MICROBES AND INFECTION

Differential HFE Gene Expression Is Regulated by Alternative Splicing in Human Tissues

(2011) Rute Martins et al.   PLoS One

The effects of iron fortification on the gut microbiota in African children: a randomized controlled trial in Côte d'Ivoire

(2010) Michael B Zimmermann et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Role of the hypoxia inducible factors HIF in iron metabolism

(2010) Carole Peyssonnaux et al.   CELL CYCLE

Risk Factors for Near-Term Myocardial Infarction in Apparently Healthy Men and Women

(2010) B. G. Nordestgaard et al.   CLINICAL CHEMISTRY

Lipofuscin-bound iron is a major intracellular source of oxidants: Role in senescent cells

(2010) Annika Höhn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Local clustering of transferrin receptors promotes clathrin-coated pit initiation

(2010) Allen P. Liu et al.   JOURNAL OF CELL BIOLOGY

Dietary intake and iron status of institutionalized elderly people: Relationship with different factors

(2010) M. J. Lopez-Contreras et al.   Journal of Nutrition Health & Aging

Inflammaging: The driving force in osteoporosis?

(2010) P. Lencel et al.   MEDICAL HYPOTHESES

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Hepcidin in Iron Metabolism

(2009) Elizabeta Nemeth et al.   ACTA HAEMATOLOGICA

Body iron excretion by healthy men and women

(2009) Janet R Hunt et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A genome-wide association analysis of serum iron concentrations

(2009) T. Tanaka et al.   BLOOD

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

(2009) Douglas B Kell   BMC Medical Genomics

A Ferroportin Transcript that Lacks an Iron-Responsive Element Enables Duodenal and Erythroid Precursor Cells to Evade Translational Repression

(2009) De-Liang Zhang et al.   Cell Metabolism

Iron absorption and metabolism

(2009) Gregory J Anderson et al.   CURRENT OPINION IN GASTROENTEROLOGY

Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis

(2009) A. J. Ramsay et al.   HAEMATOLOGICA

Hemojuvelin: The Hepcidin Story Continues

(2009) Jolanta Malyszko   KIDNEY & BLOOD PRESSURE RESEARCH

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

(2009) John C Chambers et al.   NATURE GENETICS

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

(2009) Beben Benyamin et al.   NATURE GENETICS

Iron Sequestration and Anemia of Inflammation

(2009) Tomas Ganz et al.   SEMINARS IN HEMATOLOGY

Individualized Treatment for Iron-deficiency Anemia in Adults

(2008) Michael Alleyne et al.   AMERICAN JOURNAL OF MEDICINE

Dysregulation of hepatic iron with aging: implications for heat stress-induced oxidative liver injury

(2008) Steven A. Bloomer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

Ferritins: A family of molecules for iron storage, antioxidation and more

(2008) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

(2008) A. R. Folgueras et al.   BLOOD

Iron Regulatory Proteins Are Essential for Intestinal Function and Control Key Iron Absorption Molecules in the Duodenum

(2008) Bruno Galy et al.   Cell Metabolism

An Iron Responsive Element-like Stem-Loop Regulates α-Hemoglobin-stabilizing Protein mRNA

(2008) Camila O. dos Santos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2

(2008) P. N. Paradkar et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetics of iron regulation and the possible role of iron in Parkinson's disease

(2008) Shannon L. Rhodes et al.   NEUROBIOLOGY OF DISEASE

Iron Accumulation with Age, Oxidative Stress and Functional Decline

(2008) Jinze Xu et al.   PLoS One

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Mechanisms of heme iron absorption: Current questions and controversies

(2008) Adrian R West et al.   WORLD JOURNAL OF GASTROENTEROLOGY