Impact of Autophagy and Aging on Iron Load and Ferritin in Drosophila Brain

Understanding the importance of autophagy in human diseases using Drosophila

(2019) Arindam Bhattacharjee et al.   Journal of Genetics and Genomics

Iron Deficiency Reduces Synapse Formation in the Drosophila Clock Circuit

(2018) Samuel S. Rudisill et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease

(2018) Daniel J. Colacurcio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

Amyloid precursor protein and endosomal–lysosomal dysfunction in Alzheimer’s disease: inseparable partners in a multifactorial disease

(2017) Ralph A. Nixon   FASEB JOURNAL

Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone

(2017) Kumsal Tekirdag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical imaging analysis of the brain with X-ray methods

(2017) Joanna F Collingwood et al.   SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY

Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9

(2017) Jonathan M. Goodwin et al.   Cell Reports

Accurate biometal quantification per individual Caenorhabditis elegans

(2016) Katherine Ganio et al.   ANALYST

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

LC3/GABARAP family proteins: autophagy-(un)related functions

(2016) Marco B. E. Schaaf et al.   FASEB JOURNAL

Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts

(2016) Christiane Ott et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease

(2016) Sirena Soriano et al.   PLoS One

The pupylation machinery is involved in iron homeostasis by targeting the iron storage protein ferritin

(2016) Andreas Küberl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich׳s ataxia

(2015) Juan A. Navarro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Elemental mapping of the entire intact Drosophila gastrointestinal tract

(2015) Michael W. M. Jones et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

How and why to study autophagy in Drosophila: It’s more than just a garbage chute

(2015) Péter Nagy et al.   METHODS

Iron and Neurodegeneration: Is Ferritinophagy the Link?

(2015) Giorgio Biasiotto et al.   MOLECULAR NEUROBIOLOGY

Autophagy in Alzheimer’s disease

(2015) Ameneh Zare-shahabadi et al.   REVIEWS IN THE NEUROSCIENCES

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

(2015) Joseph D Mancias et al.   eLife

Ferritin Is Required in Multiple Tissues during Drosophila melanogaster Development

(2015) Nicanor González-Morales et al.   PLoS One

Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases

(2014) Juha M.T. Hyttinen et al.   AGEING RESEARCH REVIEWS

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 inDrosophila

(2014) Péter Nagy et al.   Autophagy

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Autophagy inDrosophila: From Historical Studies to Current Knowledge

(2014) Nitha C. Mulakkal et al.   Biomed Research International

Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia

(2014) Stylianos Kosmidis et al.   Frontiers in Pharmacology

An emerging role for Cullin-3 mediated ubiquitination in sleep and circadian rhythm

(2013) Amanda A.H. Freeman et al.   FLY

The LC3 interactome at a glance

(2013) P. Wild et al.   JOURNAL OF CELL SCIENCE

Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants

(2013) I P de Castro et al.   Cell Death & Disease

Ferritin is the key to dietary iron absorption and tissue iron detoxification in Drosophila melanogaster

(2012) Xiaona Tang et al.   FASEB JOURNAL

ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex

(2012) Endalkachew Ashenafi Alemu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects

(2011) Bryan J. Bartlett et al.   Autophagy

The role of lysosomes in iron metabolism and recycling

(2011) Tino Kurz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells

(2011) T. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects

(2011) Stylianos Kosmidis et al.   NEUROBIOLOGY OF DISEASE

Detection of Genetically Altered Copper Levels in Drosophila Tissues by Synchrotron X-Ray Fluorescence Microscopy

(2011) Jessica C. Lye et al.   PLoS One

Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway

(2010) L. A. Cohen et al.   BLOOD

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferritin accumulation under iron scarcity in Drosophila iron cells

(2009) A. Mehta et al.   BIOCHIMIE

Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in aDrosophilamodel of Alzheimer’s disease

(2009) Thomas Rival et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Up-regulation of ferritin ubiquitination in skeletal muscle of transgenic rats bearing the G93A hmSOD1 gene mutation

(2009) Malgorzata Halon et al.   NEUROMUSCULAR DISORDERS

Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain

(2008) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Proteome Response to the Panneural Expression of Human Wild-Type α-Synuclein: ADrosophilaModel of Parkinson’s Disease

(2008) Zhiyin Xun et al.   JOURNAL OF PROTEOME RESEARCH