Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

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The interaction of pyridoxal isonicotinoyl hydrazone (PIH) and salicylaldehyde isonicotinoyl hydrazone (SIH) with iron

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FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase

(2018) Bin Qi et al.   CELL

Iron and ferroptosis: A still ill-defined liaison

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Iron homeostasis: An anthropocentric perspective

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Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

(2017) Mark Lucanic et al.   Nature Communications

Non-linear impact of glutathione depletion on C. elegans life span and stress resistance

(2017) Nadine Urban et al.   Redox Biology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

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Computational Analysis of Lifespan Experiment Reproducibility

(2017) Michael Petrascheck et al.   Frontiers in Genetics

Accurate biometal quantification per individual Caenorhabditis elegans

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High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans

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The temporal scaling of Caenorhabditis elegans ageing

(2016) Nicholas Stroustrup et al.   NATURE

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

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(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Profiling changes to natively-bound metals during Caenorhabditis elegans development

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Iron promotes protein insolubility and aging in C. elegans

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φXANES: In vivo imaging of metal-protein coordination environments

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Comparative Study of Metal Quantification in Neurological Tissue Using Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging and X-ray Fluorescence Microscopy

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Prooxidant and antioxidant properties of salicylaldehyde isonicotinoyl hydrazone iron chelators in HepG2 cells

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Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Is early-life iron exposure critical in neurodegeneration?

(2015) Dominic J. Hare et al.   Nature Reviews Neurology

Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans

(2015) Simon A. James et al.   Chemical Science

C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation

(2015) Jeong-Hoon Hahm et al.   Nature Communications

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

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Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging inCaenorhabditis elegans

(2014) Taro Sakamoto et al.   GENES TO CELLS

The role of iron in brain ageing and neurodegenerative disorders

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct in vivo imaging of essential bioinorganics in Caenorhabditis elegans

(2013) Simon A. James et al.   Metallomics

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

WormSizer: High-throughput Analysis of Nematode Size and Shape

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A delicate balance: Iron metabolism and diseases of the brain

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Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans

(2012) Sara Valentini et al.   MECHANISMS OF AGEING AND DEVELOPMENT

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(2012) Johannes Schindelin et al.   NATURE METHODS

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Limits of detection in XRF spectroscopy

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Loss of intestinal nuclei and intestinal integrity in aging C. elegans

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Glutathione: a key component of the cytoplasmic labile iron pool

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Dietary Restriction and Aging: A Unifying Perspective

(2011) Matthew D.W. Piper et al.   Cell Metabolism

The analysis of 2 × 2 contingency tables-Yet again

(2011) John T. E. Richardson   STATISTICS IN MEDICINE

Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity

(2010) Britta Spanier et al.   AGING CELL

Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans

(2010) Gawain McColl et al.   Cell Metabolism

The emerging role of iron dyshomeostasis in the mitochondrial decay of aging

(2010) Jinze Xu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Phenotypic and Behavioral Defects Induced by Iron Exposure Can Be Transferred to Progeny in Caenorhabditis elegans

(2009) Ya-Ou HU et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES